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Association between genetic variants related to glutamatergic, dopaminergic and neurodevelopment pathways and white matter microstructure in child and adolescent patients with obsessive–compulsive disorder

Autor: Sergi Mas, A.E. Ortiz, Astrid Morer, Luisa Lázaro, Núria Bargalló, Patricia Gassó, Anna Calvo, Amalia Lafuente

Publikováno v: Journal of Affective Disorders. 186:284-292

Background Alterations in white matter (WM) integrity observed in patients with obsessive–compulsive disorder (OCD) may be at least partly determined genetically. Neuroimaging measures of WM microstructure could serve as promising intermediate phen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8eb8ce1fd2b768d889010dc9fa025d7
https://doi.org/10.1016/j.jad.2015.07.035

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Heterophilic Type II cadherins are required for high magnitude synaptic potentiation in the hippocampus

Autor: Megan E. Williams, Xin Duan, Masahito Yamagata, E. Anne Martin, Yueqi Wang, S. Das, Luke Gangi-Wellman, Shruti Muralidhar, Matthew R. Taylor, Peter J. West, Joshua R. Sanes, Raunak Basu

Hippocampal CA3 neurons form synapses with CA1 neurons in two layers, stratum oriens (SO) and stratum radiatum (SR). Each layer develops unique synaptic properties but molecular mechanisms that mediate these differences are unknown. Here, we show tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abf7f2b318799b2c315813cb29bd3b8f
https://europepmc.org/articles/PMC5634529/

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Infertility diagnosis has a significant impact on the transcriptome of developing blastocysts

Autor: Jason C. Parks, William B. Schoolcraft, Darren K. Griffin, Blair R. McCallie, Mandy G. Katz-Jaffe

Publikováno v: Molecular human reproduction. 23(8)

Is the human blastocyst transcriptome associated with infertility diagnosis, specifically: polycystic ovaries (PCO), male factor (MF) and unexplained (UE)?The global blastocyst transcriptome was significantly altered in association with a PCO, MF and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4146080f44c79cf0db922395f899ec5d
https://pubmed.ncbi.nlm.nih.gov/28595284

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Analysis of Four Genes Involved in the Neurodevelopment Shows Association of rs4307059 Polymorphism in the Cadherin 9/10 Region with Completed Suicide

Autor: Izabela Chojnicka, Sylwia Fudalej, Grażyna Kostrzewa, Paweł Krajewski, Katarzyna Strawa, Marcin Wojnar, Marcin Fudalej, Rafał Płoski, Aleksandra Pawlak

Publikováno v: Neuropsychobiology. 66:134-140

Background: We hypothesized that DNA variants affecting neurodevelopment such as rs4307059 (CDH10/CDH9), rs930752 (NRXN1), rs6265 (BDNF) or rs10868235 (NTRK2) may predispose to completed suicide. Methodology: We used a case-control two-stage approach

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b539ca2e20caad6e0da3625f414b472
https://doi.org/10.1159/000339559

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Biparental inheritance of chromosomal abnormalities in male twins with non-syndromic mental retardation

Autor: Niels Tommerup, Ulf Kristoffersson, Merete Bugge, Reinhard Ullmann, Karen Friis Henriksen, Mette Gilling, Allan Lind-Thomsen, Morten Møller, Zeynep Tümer, Vera M. Kalscheuer, Yuan Mang, Mads Bak

Publikováno v: European Journal of Medical Genetics. 54:e383-e388

In a monozygotic twin couple with mental retardation (MR), we identified a maternally inherited inversion and a paternally inherited translocation: 46,XY,inv(10)(p11.2q21.2)mat,t(9;18)(p22;q21.1) pat. The maternally inherited inv(10) was a benign var

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::694ffc7d80991c6f58070cfba5be4a2c
https://doi.org/10.1016/j.ejmg.2011.03.008

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Cadherin-9 Regulates Synapse-Specific Differentiation in the Developing Hippocampus

Autor: Elizabeth Davis, Megan E. Williams, Mark H. Ellisman, Beth Ripley, Gerd Klein, Anthony Daggett, Stefanie Otto, Deepak Ravi, Eric A. Bushong, Scott A. Wilke, Anirvan Ghosh

SummaryOur understanding of mechanisms that regulate the differentiation of specific classes of synapses is limited. Here, we investigate the formation of synapses between hippocampal dentate gyrus (DG) neurons and their target CA3 neurons and find t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f8e39e1cd2b844e454024e621da5b5c
https://europepmc.org/articles/PMC3272880/

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Cadherin-9 Is a Novel Cell Surface Marker for the Heterogeneous Pool of Renal Fibroblasts

Autor: Hubert Kalbacher, Markus A. Kuczyk, Claudia A. Müller, Cornelia Thedieck, Gerhard A. Müller, Gerd Klein

Publikováno v: PLoS ONE, Vol 2, Iss 7, p e657 (2007)
PLoS ONE

BackgroundInterstitial fibroblasts are a minor, but nevertheless very important, component of the kidney. They secrete and remodel extracellular matrix and they produce active compounds such as erythropoietin. However, studying human renal fibroblast

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0b94ce79edb6a28f511428a540c42c3
https://doi.org/10.1371/journal.pone.0000657

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