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Autor:
Maksudul Alam, Caden O Maxwell, Janmaris Marin Fermin, Tara Moore-Medlin, Cherie-Ann O. Nathan, Chaning Burnett, Alok R. Khandelwal, Patrick T. Spiller, Xiaohua Rong
Publikováno v:
Molecular Carcinogenesis. 61:33-44
TP53 is the most frequently mutated gene in head and neck squamous cell carcinoma (HNSCC). Patients with HPV-negative TP53 mutant HNSCC have the worst prognosis, necessitating additional agents for treatment. Since mutant p53 causes sustained activat