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Tracking Subclonal Mutation Frequencies Throughout Lymphomagenesis Identifies Cancer Drivers in Mouse Models of Lymphoma

Autor: James I. Elliott, Laurence Game, Caceres Jj, Anthony G. Uren, Jakub Kaczor, Barbara Iadarola, Bruce J. Bolt, Kikkeri N. Naresh, Hamlata Dewchand, Philip Webster, Ge Tan, Joanna C. Dawes, Katalin Takacs, Alberto Paccanaro, Thomas Adejumo, Gopuraja Dharmalingam

Determining whether recurrent but rare cancer mutations are bona fide driver mutations remains a bottleneck in cancer research. Here we present the most comprehensive analysis of retrovirus driven lymphomagenesis produced to date, sequencing 700,000

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc8031ba903cf47c9625ed3b52f35bdd
https://doi.org/10.1101/157800

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LUMI-PCR: an Illumina platform ligation-mediated PCR protocol for integration site cloning, provides molecular quantitation of integration sites.

Autor: Dawes JC; 1MRC London Institute of Medical Sciences (LMS), Du Cane Road, London, W12 0NN UK.; 2Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London, UK., Webster P; 1MRC London Institute of Medical Sciences (LMS), Du Cane Road, London, W12 0NN UK.; 2Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London, UK.; 3Imperial College Healthcare NHS Trust, London, UK., Iadarola B; 1MRC London Institute of Medical Sciences (LMS), Du Cane Road, London, W12 0NN UK.; 2Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London, UK., Garcia-Diaz C; 4Samantha Dickson Brain Cancer Unit, UCL Cancer Institute, WC1E 6DD, London, UK., Dore M; 1MRC London Institute of Medical Sciences (LMS), Du Cane Road, London, W12 0NN UK.; 2Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London, UK., Bolt BJ; 1MRC London Institute of Medical Sciences (LMS), Du Cane Road, London, W12 0NN UK.; 2Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London, UK., Dewchand H; 1MRC London Institute of Medical Sciences (LMS), Du Cane Road, London, W12 0NN UK.; 2Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London, UK., Dharmalingam G; 1MRC London Institute of Medical Sciences (LMS), Du Cane Road, London, W12 0NN UK.; 2Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London, UK., McLatchie AP; 5UCL Cancer Institute, WC1E 6DD, London, UK., Kaczor J; 1MRC London Institute of Medical Sciences (LMS), Du Cane Road, London, W12 0NN UK.; 2Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London, UK., Caceres JJ; 6Centre for Systems and Synthetic Biology, Department of Computer Science, Royal Holloway, University of London, London, UK., Paccanaro A; 6Centre for Systems and Synthetic Biology, Department of Computer Science, Royal Holloway, University of London, London, UK., Game L; 1MRC London Institute of Medical Sciences (LMS), Du Cane Road, London, W12 0NN UK.; 2Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London, UK., Parrinello S; 4Samantha Dickson Brain Cancer Unit, UCL Cancer Institute, WC1E 6DD, London, UK., Uren AG; 1MRC London Institute of Medical Sciences (LMS), Du Cane Road, London, W12 0NN UK.; 2Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London, UK.

Publikováno v: Mobile DNA [Mob DNA] 2020 Feb 04; Vol. 11, pp. 7. Date of Electronic Publication: 2020 Feb 04 (Print Publication: 2020).

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Author Correction: Subclonal mutation selection in mouse lymphomagenesis identifies known cancer loci and suggests novel candidates.

Autor: Webster P; MRC London Institute of Medical Sciences (LMS), Du Cane Road, London, W12 0NN, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK.; Imperial College Healthcare NHS Trust, London, W12 0HS, UK., Dawes JC; MRC London Institute of Medical Sciences (LMS), Du Cane Road, London, W12 0NN, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK., Dewchand H; MRC London Institute of Medical Sciences (LMS), Du Cane Road, London, W12 0NN, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK., Takacs K; MRC London Institute of Medical Sciences (LMS), Du Cane Road, London, W12 0NN, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK., Iadarola B; MRC London Institute of Medical Sciences (LMS), Du Cane Road, London, W12 0NN, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK., Bolt BJ; MRC London Institute of Medical Sciences (LMS), Du Cane Road, London, W12 0NN, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK., Caceres JJ; Centre for Systems and Synthetic Biology, Department of Computer Science, Royal Holloway, University of London, TW20 0EX, Egham, UK., Kaczor J; MRC London Institute of Medical Sciences (LMS), Du Cane Road, London, W12 0NN, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK., Dharmalingam G; MRC London Institute of Medical Sciences (LMS), Du Cane Road, London, W12 0NN, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK., Dore M; MRC London Institute of Medical Sciences (LMS), Du Cane Road, London, W12 0NN, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK., Game L; MRC London Institute of Medical Sciences (LMS), Du Cane Road, London, W12 0NN, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK., Adejumo T; MRC London Institute of Medical Sciences (LMS), Du Cane Road, London, W12 0NN, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK., Elliott J; MRC London Institute of Medical Sciences (LMS), Du Cane Road, London, W12 0NN, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK., Naresh K; Imperial College Healthcare NHS Trust, London, W12 0HS, UK., Karimi M; MRC London Institute of Medical Sciences (LMS), Du Cane Road, London, W12 0NN, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK., Rekopoulou K; MRC London Institute of Medical Sciences (LMS), Du Cane Road, London, W12 0NN, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK., Tan G; MRC London Institute of Medical Sciences (LMS), Du Cane Road, London, W12 0NN, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK., Paccanaro A; Centre for Systems and Synthetic Biology, Department of Computer Science, Royal Holloway, University of London, TW20 0EX, Egham, UK., Uren AG; MRC London Institute of Medical Sciences (LMS), Du Cane Road, London, W12 0NN, UK. anthonyuren@gmail.com.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK. anthonyuren@gmail.com.

Publikováno v: Nature communications [Nat Commun] 2019 Mar 06; Vol. 10 (1), pp. 1167. Date of Electronic Publication: 2019 Mar 06.

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Subclonal mutation selection in mouse lymphomagenesis identifies known cancer loci and suggests novel candidates.

Autor: Webster P; MRC London Institute of Medical Sciences (LMS), Du Cane Road, London, W12 0NN, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK.; Imperial College Healthcare NHS Trust, London, W12 0HS, UK., Dawes JC; MRC London Institute of Medical Sciences (LMS), Du Cane Road, London, W12 0NN, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK., Dewchand H; MRC London Institute of Medical Sciences (LMS), Du Cane Road, London, W12 0NN, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK., Takacs K; MRC London Institute of Medical Sciences (LMS), Du Cane Road, London, W12 0NN, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK., Iadarola B; MRC London Institute of Medical Sciences (LMS), Du Cane Road, London, W12 0NN, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK., Bolt BJ; MRC London Institute of Medical Sciences (LMS), Du Cane Road, London, W12 0NN, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK., Caceres JJ; Centre for Systems and Synthetic Biology, Department of Computer Science, Royal Holloway, University of London, Egham, TW20 0EX, UK., Kaczor J; MRC London Institute of Medical Sciences (LMS), Du Cane Road, London, W12 0NN, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK., Dharmalingam G; MRC London Institute of Medical Sciences (LMS), Du Cane Road, London, W12 0NN, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK., Dore M; MRC London Institute of Medical Sciences (LMS), Du Cane Road, London, W12 0NN, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK., Game L; MRC London Institute of Medical Sciences (LMS), Du Cane Road, London, W12 0NN, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK., Adejumo T; MRC London Institute of Medical Sciences (LMS), Du Cane Road, London, W12 0NN, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK., Elliott J; MRC London Institute of Medical Sciences (LMS), Du Cane Road, London, W12 0NN, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK., Naresh K; Imperial College Healthcare NHS Trust, London, W12 0HS, UK., Karimi M; MRC London Institute of Medical Sciences (LMS), Du Cane Road, London, W12 0NN, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK., Rekopoulou K; MRC London Institute of Medical Sciences (LMS), Du Cane Road, London, W12 0NN, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK., Tan G; MRC London Institute of Medical Sciences (LMS), Du Cane Road, London, W12 0NN, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK., Paccanaro A; Centre for Systems and Synthetic Biology, Department of Computer Science, Royal Holloway, University of London, Egham, TW20 0EX, UK., Uren AG; MRC London Institute of Medical Sciences (LMS), Du Cane Road, London, W12 0NN, UK. anthonyuren@gmail.com.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK. anthonyuren@gmail.com.

Publikováno v: Nature communications [Nat Commun] 2018 Jul 09; Vol. 9 (1), pp. 2649. Date of Electronic Publication: 2018 Jul 09.

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