Výsledky vyhledávání

A20 ameliorates disc degeneration by suppressing mTOR/BNIP3 axis-mediated mitophagy

Autor: Xin, Peng, Cong, Zhang, Jia-Wei, Gao, Feng, Wang, Jun-Ping, Bao, Zhi-Min, Zhou, Rui, Sun, Hang-Yu, Ji, Cabral, Vlf, Xiao-Tao, Wu

Publikováno v: Genes & Genomics. 45:657-671

The pathological mechanism of intervertebral disc degeneration (IDD) is an unanswered question that we are committed to exploring. A20 is an anti-inflammatory protein of nucleus pulposus (NP) cells and plays a protective role in intervertebral disc d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c1f9b1bbac28455e7044da3fdfb471f
https://doi.org/10.1007/s13258-022-01343-9

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Small extracellular vesicles from hypoxic mesenchymal stem cells alleviate intervertebral disc degeneration by delivering miR-17-5p

Autor: Zhi-Min, Zhou, Jun-Ping, Bao, Xin, Peng, Jia-Wei, Gao, Cabral, Vlf, Cong, Zhang, Rui, Sun, Kun-Wang, Xiao-Tao, Wu

Publikováno v: Acta Biomaterialia. 140:641-658

Minimally invasive repair strategies are a very promising approach for the treatment of intervertebral disc degeneration (IDD). In recent years, small extracellular vesicles (sEVs) secreted from mesenchymal stem cells (MSCs) have been shown great pot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb2056a756eaede49434c3943d3a2a1f
https://doi.org/10.1016/j.actbio.2021.11.044

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The mitochondrial antioxidant SS-31 attenuated lipopolysaccharide-induced apoptosis and pyroptosis of nucleus pulposus cells via scavenging mitochondrial ROS and maintaining the stability of mitochondrial dynamics

Autor: Xin Peng, Kun Wang, Cong Zhang, Jun-Ping Bao, Cabral Vlf, Jia-Wei Gao, Zhi-Min Zhou, Xiao-Tao Wu

Publikováno v: Free radical research. 55(11-12)

Evidence has shown that effects from inflammation and mitochondrial dysfunction lead to pyroptosis and apoptosis of nucleus pulposus (NP) cells. Damaged mitochondria release dangerous molecules such as reactive oxygen species (ROS), activating the NL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af1007aa4edd9b3ea97e6fc480dc43ad
https://pubmed.ncbi.nlm.nih.gov/34903138

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Akademický článek

Inhibition of OLR1 reduces SASP of nucleus pulposus cells by targeting autophagy-GATA4 axis.

Autor: Gao JW; Department of Spine Center, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, 210009, China., Shi H; Department of Spine Center, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, 210009, China., Gao FP; Department of Pathology, Gaochun People's Hospital, Nanjing, Jiangsu, 211300, China., Zhou ZM; Department of Spine Center, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, 210009, China., Peng X; Department of Spine Center, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, 210009, China., Sun R; Department of Spine Center, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, 210009, China., Cabral VLF; Department of Spine Center, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, 210009, China., Li J; Department of Orthopaedic, Xuyi People's Hospital, Huaian, Jiangsu, 211600, China., Wang YT; Department of Spine Center, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, 210009, China.; Department of Orthopaedic, Xuyi People's Hospital, Huaian, Jiangsu, 211600, China., Wang XH; Department of Spine Center, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, 210009, China., Wu XT; Department of Spine Center, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, 210009, China.

Publikováno v: The journals of gerontology. Series A, Biological sciences and medical sciences [J Gerontol A Biol Sci Med Sci] 2024 Aug 23. Date of Electronic Publication: 2024 Aug 23.

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Akademický článek

Omentin-1 promoted proliferation and ameliorated inflammation, apoptosis, and degeneration in human nucleus pulposus cells.

Autor: Cabral VLF; Department of Spine Surgery, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu 230003, China; School of Medicine, Southeast University, Nanjing, Jiangsu 230003, China., Wang F; Department of Spine Surgery, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu 230003, China., Peng X; Department of Spine Surgery, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu 230003, China; School of Medicine, Southeast University, Nanjing, Jiangsu 230003, China., Gao J; Department of Spine Surgery, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu 230003, China; School of Medicine, Southeast University, Nanjing, Jiangsu 230003, China., Zhou Z; Department of Spine Surgery, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu 230003, China; School of Medicine, Southeast University, Nanjing, Jiangsu 230003, China., Sun R; Department of Spine Surgery, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu 230003, China; School of Medicine, Southeast University, Nanjing, Jiangsu 230003, China., Bao J; Department of Spine Surgery, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu 230003, China; School of Medicine, Southeast University, Nanjing, Jiangsu 230003, China., Wu X; Department of Spine Surgery, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu 230003, China; School of Medicine, Southeast University, Nanjing, Jiangsu 230003, China. Electronic address: wuxiaotaospine@seu.edu.cn.

Publikováno v: Archives of gerontology and geriatrics [Arch Gerontol Geriatr] 2022 Sep-Oct; Vol. 102, pp. 104748. Date of Electronic Publication: 2022 Jun 09.

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Akademický článek

A20 attenuates pyroptosis and apoptosis in nucleus pulposus cells via promoting mitophagy and stabilizing mitochondrial dynamics.

Autor: Peng X; Medical School of Southeast University, Nanjing, China., Zhang C; Department of Orthopedics, Zhongda Hospital, Southeast University, Nanjing, China., Zhou ZM; Department of Orthopedics, Zhongda Hospital, Southeast University, Nanjing, China., Wang K; Department of Orthopedics, Zhongda Hospital, Southeast University, Nanjing, China., Gao JW; Medical School of Southeast University, Nanjing, China., Qian ZY; Medical School of Southeast University, Nanjing, China., Bao JP; Medical School of Southeast University, Nanjing, China., Ji HY; Department of Orthopedics, Zhongda Hospital, Southeast University, Nanjing, China., Cabral VLF; Medical School of Southeast University, Nanjing, China., Wu XT; Medical School of Southeast University, Nanjing, China. wuxiaotaospine@seu.edu.cn.; Department of Orthopedics, Zhongda Hospital, Southeast University, Nanjing, China. wuxiaotaospine@seu.edu.cn.

Publikováno v: Inflammation research : official journal of the European Histamine Research Society ... [et al.] [Inflamm Res] 2022 Jun; Vol. 71 (5-6), pp. 695-710. Date of Electronic Publication: 2022 Apr 15.

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