[F-18]CFA as a clinically translatable probe for PET imaging of deoxycytidine kinase activity

Autor: Kim, W, Le, TM, Wei, L, Poddar, S, Bazzy, J, Wang, X, Uong, NT, Abt, ER, Capri, JR, Austin, WR, Van Valkenburgh, JS, Steele, D, Gipson, RM, Slavik, R, Cabebe, AE, Taechariyakul, T, Yaghoubi, SS, Lee, JT, Sadeghi, S, Lavie, A, Faull, KF, Witte, ON, Donahue, TR, Phelps, ME, Herschman, HR, Herrmann, K, Czernin, J, Radu, CG

Publikováno v: Kim, W; Le, TM; Wei, L; Poddar, S; Bazzy, J; Wang, X; et al.(2016). [F-18]CFA as a clinically translatable probe for PET imaging of deoxycytidine kinase activity. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113(15), 4027-4032. doi: 10.1073/pnas.1524212113. UCLA: Retrieved from: http://www.escholarship.org/uc/item/5df0b26k

Deoxycytidine kinase (dCK), a rate-limiting enzyme in the cytosolic deoxyribonucleoside (dN) salvage pathway, is an important therapeutic and positron emission tomography (PET) imaging target in cancer. PET probes for dCK have been developed and are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::83aff45cec59a753f44b20949e3ddf4a
http://www.escholarship.org/uc/item/5df0b26k

Rhesus Theta Defensin 1 Promotes Long Term Survival in Systemic Candidiasis by Host Directed Mechanisms.

Autor: Basso V; Department of Pathology and Laboratory Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America., Tran DQ; Department of Pathology and Laboratory Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America.; Oryn Therapeutics, Vacaville, California, United States of America., Schaal JB; Department of Pathology and Laboratory Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America., Tran P; Department of Pathology and Laboratory Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America., Eriguchi Y; Department of Pathology and Laboratory Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America.; Department of Clinical Immunology and Rheumatology/Infectious DiseaseKyushu University HospitalDepartment of Medicine and Biosystemic ScienceKyushu University Graduate School of Medical Science, Fukuoka, Japan., Ngole D; Department of Pathology and Laboratory Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America., Cabebe AE; Department of Pathology and Laboratory Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America., Park AY; Department of Clinical Pharmacy, School of Pharmacy, University of Southern California, Los Angeles, United States of America., Beringer PM; Department of Clinical Pharmacy, School of Pharmacy, University of Southern California, Los Angeles, United States of America., Ouellette AJ; Department of Pathology and Laboratory Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America.; Norris Comprehensive Cancer Center of the University of Southern California, Los Angeles, California, United States of America., Selsted ME; Department of Pathology and Laboratory Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America. selsted@med.usc.edu.; Oryn Therapeutics, Vacaville, California, United States of America. selsted@med.usc.edu.; Norris Comprehensive Cancer Center of the University of Southern California, Los Angeles, California, United States of America. selsted@med.usc.edu.

Publikováno v: Scientific reports [Sci Rep] 2019 Nov 15; Vol. 9 (1), pp. 16905. Date of Electronic Publication: 2019 Nov 15.

[18F]CFA as a clinically translatable probe for PET imaging of deoxycytidine kinase activity.

Autor: Kim W; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095; Ahmanson Translational Imaging Division, University of California, Los Angeles, CA 90095;, Le TM; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095; Ahmanson Translational Imaging Division, University of California, Los Angeles, CA 90095;, Wei L; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095; Ahmanson Translational Imaging Division, University of California, Los Angeles, CA 90095;, Poddar S; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095; Ahmanson Translational Imaging Division, University of California, Los Angeles, CA 90095;, Bazzy J; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095; Ahmanson Translational Imaging Division, University of California, Los Angeles, CA 90095;, Wang X; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095; Ahmanson Translational Imaging Division, University of California, Los Angeles, CA 90095;, Uong NT; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095; Ahmanson Translational Imaging Division, University of California, Los Angeles, CA 90095;, Abt ER; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095; Ahmanson Translational Imaging Division, University of California, Los Angeles, CA 90095;, Capri JR; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095; Ahmanson Translational Imaging Division, University of California, Los Angeles, CA 90095;, Austin WR; Abcam, Cambridge, MA 02139-1517;, Van Valkenburgh JS; Ahmanson Translational Imaging Division, University of California, Los Angeles, CA 90095; Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095;, Steele D; Ahmanson Translational Imaging Division, University of California, Los Angeles, CA 90095; Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095;, Gipson RM; Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095;, Slavik R; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095; Ahmanson Translational Imaging Division, University of California, Los Angeles, CA 90095;, Cabebe AE; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095; Ahmanson Translational Imaging Division, University of California, Los Angeles, CA 90095;, Taechariyakul T; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095; Ahmanson Translational Imaging Division, University of California, Los Angeles, CA 90095;, Yaghoubi SS; CellSight Technologies, Inc., San Francisco, CA 94107;, Lee JT; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095; Crump Institute for Molecular Imaging, University of California, Los Angeles, CA 90095;, Sadeghi S; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095; Ahmanson Translational Imaging Division, University of California, Los Angeles, CA 90095;, Lavie A; Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607;, Faull KF; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095; Ahmanson Translational Imaging Division, University of California, Los Angeles, CA 90095; The Pasarow Mass Spectrometry Laboratory, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095;, Witte ON; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095; Department of Microbiology, Immunology, & Molecular Genetics, University of California, Los Angeles, CA 90095; Howard Hughes Medical Institute, University of California, Los Angeles, CA 90095; Eli & Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, CA 90095;, Donahue TR; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095; Ahmanson Translational Imaging Division, University of California, Los Angeles, CA 90095; Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles, CA 90095;, Phelps ME; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095; Crump Institute for Molecular Imaging, University of California, Los Angeles, CA 90095; cradu@mednet.ucla.edu mphelps@mednet.ucla.edu., Herschman HR; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095; Ahmanson Translational Imaging Division, University of California, Los Angeles, CA 90095; Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, CA 90095., Herrmann K; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095; Ahmanson Translational Imaging Division, University of California, Los Angeles, CA 90095;, Czernin J; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095; Ahmanson Translational Imaging Division, University of California, Los Angeles, CA 90095;, Radu CG; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095; Ahmanson Translational Imaging Division, University of California, Los Angeles, CA 90095; cradu@mednet.ucla.edu mphelps@mednet.ucla.edu.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2016 Apr 12; Vol. 113 (15), pp. 4027-32. Date of Electronic Publication: 2016 Mar 28.