Zobrazeno 1 - 10
of 126
pro vyhledávání: '"CaMKKβ"'
Autor:
Qing Li, Huixian Li, Ruiwen Zhu, William Chi Shing Cho, Xiaoqiang Yao, Fung Ping Leung, Gary Tse, Lai Kwok Leung, Wing Tak Wong
Publikováno v:
Cancer Cell International, Vol 24, Iss 1, Pp 1-19 (2024)
Abstract Breast cancer, the most prevalent and aggressive tumor affecting women, requires identification of disease determinants to facilitate the development of effective therapeutic strategies. Transient receptor potential vanilloid 2 (TRPV2), an i
Externí odkaz:
https://doaj.org/article/5a81e9ea7a05451ab3eab97ff35c7f25
Autor:
Yanling Huang, Haocong Mo, Jie Yang, Luyang Gao, Tian Tao, Qing Shu, Wenying Guo, Yawen Zhao, Jingya Lyu, Qimeng Wang, Jinghui Guo, Hening Zhai, Linyan Zhu, Hui Chen, Geyang Xu
Publikováno v:
eLife, Vol 13 (2024)
Glucagon-like peptide 1 (GLP-1) is a gut-derived hormone secreted by intestinal L cells and vital for postprandial glycemic control. As open-type enteroendocrine cells, whether L cells can sense mechanical stimuli caused by chyme and thus regulate GL
Externí odkaz:
https://doaj.org/article/eb257dc2f9fd413daa5bdd3902f61cde
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Disturbance in mitochondrial homeostasis within proximal tubules is a critical characteristic associated with diabetic kidney disease (DKD). CaMKKβ/AMPK signaling plays an important role in regulating mitochondrial homeostasis. Despite the
Externí odkaz:
https://doaj.org/article/16eb2adac8344bcc83f78e7bb76aa995
Publikováno v:
Renal Failure, Vol 46, Iss 1 (2024)
Objective Liraglutide, a glucagon-like peptide-1 receptor agonist, has been shown to regulate blood sugar and control body weight, but its ability to treat obesity-related nephropathy has been poorly studied. Therefore, this study was designed to obs
Externí odkaz:
https://doaj.org/article/ce39ac4468a24c868423c11c1d2c3624
Autor:
Jinli Luo, Wenqi Jin, Meiying Jin, Weiwei Pan, Shengnan Gao, Xiaohua Zhao, Xingrong Lai, Liwei Sun, Chunli Piao
Publikováno v:
Pharmaceutical Biology, Vol 60, Iss 1, Pp 1542-1555 (2022)
Context Jiedutongluotiaogan formula (JTTF), a traditional Chinese medicine (TCM), could promote islet function. However, the potential effect of JTTF on endoplasmic reticulum stress (ERS) and autophagy have not been reported.Objective This study expl
Externí odkaz:
https://doaj.org/article/22aa0b3261bd4838902412d2320d4236
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionCalmodulin-dependent protein kinase β (CaMKKβ) is closely related to Ca2+ concentration. An increase in Ca2+ concentration in the cytoplasm activates CaMKKβ, and activated CaMKKβ affects the activities of AMPK and mTOR and induces aut
Externí odkaz:
https://doaj.org/article/8d80a2fc4241403aaeda48fd3fa16396
Microcystin leucine arginine induces human sperm damage: Involvement of the Ca2+/CaMKKβ/AMPK pathway
Autor:
Xing Guo, Ruiyang Meng, Junjie Liu, Shiyu Zhang, Haohao Liu, Xingde Du, Huizhen Zhang, Yushan Li
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 256, Iss , Pp 114845- (2023)
As a common pollutant in the water environment, microcystin leucine arginine (MC-LR) can enter semen and damage the sperm in animals. However, the mechanism by which MC-LR damages human sperm is unclear. Therefore, human sperm samples were obtained f
Externí odkaz:
https://doaj.org/article/6323dfdf4703485e9b27d70d33604b61
Autor:
Juanjuan Liang, Lili Gu, Xianli Liu, Xintong Yan, Xiaowen Bi, Xirui Fan, Jinyi Zhou, Shuai Lu, Lan Luo, Zhimin Yin
Publikováno v:
Nutrition & Metabolism, Vol 19, Iss 1, Pp 1-17 (2022)
Abstract Background L-theanine, a non-protein amino acid was found principally in the green tea, has been previously shown to exhibit potent anti-obesity property and hepatoprotective effect. Herein, we investigated the effects of L-theanine on allev
Externí odkaz:
https://doaj.org/article/af9bac2464f645bbbf76ad46967ef374
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Akademický článek
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