Zobrazeno 1 - 10
of 1 870
pro vyhledávání: '"Ca2 oscillations"'
Autor:
Tsutomu Sasaki, Sunao Hisada, Hideaki Kanki, Kazuto Nunomura, Bangzhong Lin, Kumiko Nishiyama, Tomohito Kawano, Shigenobu Matsumura, Hideki Mochizuki
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Calcium oscillations in primary neuronal cultures and iPSCs have been employed to investigate arrhythmogenicity and epileptogenicity in drug development. Previous studies have demonstrated that Ca2+ influx via NMDA and nicotinic acetylcholin
Externí odkaz:
https://doaj.org/article/9b6e3447e8e248359c5367162194bbbc
Autor:
Chen Chen, Zefan Huang, Shijue Dong, Mengqian Ding, Jinran Li, Miaomiao Wang, Xuhui Zeng, Xiaoning Zhang, Xiaoli Sun
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
Calcium (Ca2+) is a second messenger for many signal pathways, and changes in intracellular Ca2+ concentration ([Ca2+]i) are an important signaling mechanism in the oocyte maturation, activation, fertilization, function regulation of granulosa and cu
Externí odkaz:
https://doaj.org/article/59999e8cf6374a478aac1a003bd4c761
Publikováno v:
Physiological Reports, Vol 11, Iss 14, Pp n/a-n/a (2023)
Abstract All currently employed pharmaceutical formulations of hydroxychloroquine (HCQ) sulfate are a racemate, consisting of equal parts mixture of two stereoisomers: R(−)HCQ and S(+)HCQ sulfates. The aims of the current study were first, to obtai
Externí odkaz:
https://doaj.org/article/3c5ea4593e2b4ceaa4607f35db92e664
Autor:
Zijian Zeng, Mengxin Cheng, Meng Li, Tao Wang, Fuqiang Wen, Michael J. Sanderson, James Sneyd, Yongchun Shen, Jun Chen
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
BALB/c and C57BL/6 mouse strains are widely used as animal model in studies of respiratory diseases, such as asthma. Asthma is characterized by airway hyperresponsiveness, which is eventually resulted from the excessive airway smooth muscle (ASM) con
Externí odkaz:
https://doaj.org/article/febcca5630c94857b017f7e4f52ca099
Autor:
Roberto Berra-Romani, Ajelet Vargaz-Guadarrama, Josué Sánchez-Gómez, Nayeli Coyotl-Santiago, Efraín Hernández-Arambide, José Everardo Avelino-Cruz, Mario García-Carrasco, Monica Savio, Giorgia Pellavio, Umberto Laforenza, Alfredo Lagunas-Martínez, Francesco Moccia
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Histamine is an inflammatory mediator that can be released from mast cells to induce airway remodeling and cause persistent airflow limitation in asthma. In addition to stimulating airway smooth muscle cell constriction and hyperplasia, histamine pro
Externí odkaz:
https://doaj.org/article/2976a1a97f9f497d8c8b06d19df3de87
Akademický článek
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Akademický článek
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Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Adenomyosis is a debilitating gynecological disease of the uterus with no medicinal cure. The tissue injury and repair hypothesis for adenomyosis suggests that uterine hyperperistalsis or dysperistalsis plays a pivotal role in establishing adenomyoti
Externí odkaz:
https://doaj.org/article/cb5ede8cc3dd45728c0519cc0bc54de4
Autor:
Nadine J. Ortner
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 13 (2021)
The loss of dopamine (DA)-producing neurons in the substantia nigra pars compacta (SN) underlies the core motor symptoms of the progressive movement disorder Parkinson's disease (PD). To date, no treatment to prevent or slow SN DA neurodegeneration e
Externí odkaz:
https://doaj.org/article/77756958698b4d8cbb2b5ca893f2f80f
Autor:
Feng Wang, Tie-Gang Meng, Jian Li, Yi Hou, Shi-Ming Luo, Heide Schatten, Qing-Yuan Sun, Xiang-Hong Ou
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Mitochondrial energy insufficiency is strongly associated with oocyte activation disorders. Ca2+, especially that in the mitochondrial matrix, plays a pivotal role in mitochondrial energy supplementation, but the underlying mechanisms are still only
Externí odkaz:
https://doaj.org/article/3f2fc3d524f34870a463445817fcb17f