Výsledky vyhledávání - "Ca2 activated k channel"

Small-conductance Ca2+-activated K+channel activation deteriorates hypoxic ventricular arrhythmias via CaMKII in cardiac hypertrophy

Autor: Hisashi Yokoshiki, Masayuki Takahashi, Taro Tenma, Yutaro Otsuka, Shingo Takada, Hisataka Sabe, Masaya Watanabe, Naoya Kakutani, Rui Kamada, Hiroyuki Tsutsui, Hirofumi Mitsuyama, Kazuya Mizukami

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 315:H262-H272

The molecular and electrophysiological mechanisms of acute ischemic ventricular arrhythmias in hypertrophied hearts are not well known. We hypothesized that small-conductance Ca2+-activated K+(SK) channels are activated during hypoxia via the Ca2+/ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8cd2f1141650cb50db7b94e8fcbb6142
https://doi.org/10.1152/ajpheart.00636.2017

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Functional Roles of the Ca2+-activated K+ Channel, KCa3.1, in Brain Tumors

Autor: Myriam Catalano, Cristina Limatola, Giuseppina D'Alessandro

Publikováno v: Current Neuropharmacology

Background Glioblastoma is the most aggressive and deadly brain tumor, with low disease-free period even after surgery and combined radio and chemotherapies. Among the factors contributing to the devastating effect of this tumor in the brain are the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fb5267e3d0f8d1b3d305d4032670d89
https://doi.org/10.2174/0929867324666170713103621

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P703The small conductance Ca2+-activated K+-channel inhibition tool compound AP14145 protected the guinea pig heart from ventricular arrhythmia during hypokalemia whereas dofetilide was pro-arrhythmic

Autor: M Grunnet, U S Soerensen, L Abildgaard, Bo Hjorth Bentzen, Nils Edvardsson, J G Diness

Publikováno v: European Heart Journal. 40

Background Hypokalemia is commonly encountered in the clinic. Hypokalemia reduces the cardiac repolarization reserve and causes increases in intracellular calcium. This prolongs the QT-interval and increases the risk of ventricular arrhythmia; a risk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::30882599f18c30d0f40ff663ab77171e
https://doi.org/10.1093/eurheartj/ehz747.0308

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Expression and Modulation of the Intermediate- Conductance Ca2+-Activated K+ Channel in Glioblastoma GL-15 Cells

Autor: Maria Rita Micheli, Miriam Sciaccaluga, Alexander A. Harper, Bernard Fioretti, Rodolfo Bova, Emilia Castigli, Fabio Franciolini, Luigi Catacuzzeno

Publikováno v: Cellular Physiology and Biochemistry. 18:47-56

We report here the expression and properties of the intermediate-conductance Ca2+-activated K+ (IKCa) channel in the GL-15 human glioblastoma cell line. Macroscopic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::284fb3f53c8226cffc35eea42301f2f2
https://doi.org/10.1159/000095135

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Nitric Oxide Stimulates a Large-Conductance Ca2+-Activated K+ Channel in Human Skin Fibroblasts through Protein Kinase G Pathway

Autor: C. Lee, Seong Jin Kim, Inja Lim, S. Seo, H. Bang, Jihyun Yun, T. Kim

Publikováno v: Skin Pharmacology and Physiology. 18:279-287

In order to investigate the large-conductance Ca2+-activated K+ (BKCa) channel and determine the effects of nitric oxide (NO) on the channel in human skin fibroblasts, we performed electrophysiological patch clamp recordings on 5th-passage cells of h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8b972ca49e9556fbe31cf832cc7f1a37
https://doi.org/10.1159/000088013

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Cloning and Expression of a Small-Conductance Ca2+-Activated K+ Channel From the Mouse Cochlea: Coexpression with α9/α10 Acetylcholine Receptors

Autor: Kirk W. Beisel, Liping Nie, Ebenezer N. Yamoah, Mei Fang Chen, Haitao Song, Nipavan Chiamvimonvat, Ana E. Vázquez

Publikováno v: Journal of Neurophysiology. 91:1536-1544

Functional interactions between ligand-gated, voltage-, and Ca2+-activated ion channels are essential to the properties of excitable cells and thus to the working of the nervous system. The outer hair cells in the mammalian cochlea receive efferent i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2f26a5836e1656f4eebd1d4b99151f5
https://doi.org/10.1152/jn.00630.2003

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