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Akademický článek

'A Step and a Ceiling': mechanical properties of Ca2+ spark vasoregulation in resistance arteries by pressure‐induced oxidative activation of PKG

Autor: Viktoria Csato, Sharifah Z. S. A. Kadir, Kaivan Khavandi, Hayley Bennett, Sarah Sugden, Alison M. Gurney, Harry A. T. Pritchard, David Hill‐Eubanks, Philip Eaton, Mark T. Nelson, Adam S. Greenstein

Publikováno v: Physiological Reports, Vol 7, Iss 22, Pp n/a-n/a (2019)

Abstract We investigated the biomechanical relationship between intraluminal pressure within small mesenteric resistance arteries, oxidant activation of PKG, Ca2+ sparks, and BK channel vasoregulation. Mesenteric resistance arteries from wild type (W

Externí odkaz: https://doaj.org/article/8785c9dfa9f3404c9c302b284da289f5

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Akademický článek

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Akademický článek

Ryanodine receptor dispersion disrupts Ca2+ release in failing cardiac myocytes

Autor: Terje R Kolstad, Jonas van den Brink, Niall MacQuaide, Per Kristian Lunde, Michael Frisk, Jan Magnus Aronsen, Einar S Norden, Alessandro Cataliotti, Ivar Sjaastad, Ole M Sejersted, Andrew G Edwards, Glenn Terje Lines, William E Louch

Publikováno v: eLife, Vol 7 (2018)

Reduced cardiac contractility during heart failure (HF) is linked to impaired Ca2+ release from Ryanodine Receptors (RyRs). We investigated whether this deficit can be traced to nanoscale RyR reorganization. Using super-resolution imaging, we observe

Externí odkaz: https://doaj.org/article/6cff6348d4064cf683d6e930c578727b

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Akademický článek

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Akademický článek

Effects of rogue ryanodine receptors on Ca2+ sparks in cardiac myocytes

Autor: Xudong Chen, Yundi Feng, Yunlong Huo, Wenchang Tan

Publikováno v: Royal Society Open Science, Vol 5, Iss 2 (2018)

Ca2+ sparks and Ca2+ quarks, arising from clustered and rogue ryanodine receptors (RyRs), are significant Ca2+ release events from the junctional sarcoplasmic reticulum (JSR). Based on the anomalous subdiffusion of Ca2+ in the cytoplasm, a mathematic

Externí odkaz: https://doaj.org/article/c2591762cfab40c2a34363d786dd91ad

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IP3R activity increases frequency of RyR-mediated sparks by elevating dyadic Ca2+

Autor: Joshua Chung, Agnė Tilūnaitė, David Ladd, Hilary Hunt, Christian Soeller, Edmund J. Crampin, Stuart Johnston, H. Llewelyn Roderick, Vijay Rajagopal

Calcium plays critical roles in cardiac cells, coupling electrical excitation to mechanical contraction with each heartbeat, while simultaneously mediating biochemical signals that regulate cell growth. While ryanodine receptors (RyRs) are fundamenta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5e07e4e3cffd2997022b50405ad3c895
https://doi.org/10.1101/2020.08.13.249144

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Hierarchical statistical techniques are necessary to draw reliable conclusions from analysis of isolated cardiomyocyte studies

Autor: Sikkel, MB, Francis, DP, Howard, J, Gordon, F, Rowlands, C, Peters, NS, Lyon, AR, Harding, SE, MacLeod, KT

Publikováno v: Cardiovascular Research

Aims It is generally accepted that post-MI heart failure (HF) changes a variety of aspects of sarcoplasmic reticular Ca2+ fluxes but for some aspects there is disagreement over whether there is an increase or decrease. The commonest statistical appro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5ca0267573962086849f2dd6d2991c54
http://europepmc.org/articles/PMC5852514

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Reduced Ca

Autor: Ji, Zheng, Hao, Zhou, Mengjun, Yang, Siji, Song, Qiang, Dai, Guangju, Ji, Zhansong, Zhou

Publikováno v: Aging (Albany NY)

We tested whether or not altered Ca2+ spark activity accounted for detrusor overactivity (DO) of Wistar rats after partial bladder outlet obstruction (PBOO). We constructed a DO model through PBOO and studied the Ca2+ spark activity of detrusor. By w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cd4d2f1ad2ed02433e6ff55b883bb465
https://pubmed.ncbi.nlm.nih.gov/32112553

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