Effects of Prosopis farcta Root Extract in the Vascular Reactivity of Isolated Goat Coronary Artery

Autor: Rezhna Adil Rasheed, Ismail Salih Ibrahim Kakey

Publikováno v: Kurdistan Journal of Applied Research, Vol 4, Iss 3 (2019)

Prosopis species is a medicinal plant, well-known for its beneficial effects in treating various smooth muscles disorders, and its phytochemical analysis revealed the presence of different bioactive compounds in different parts of the plant, most of

Externí odkaz: https://doaj.org/article/34c892e1631a462bada83530961df28a

Oxostephanine, Thalmiculine, and Thaliphyline—Three Isoquinoleine Alkaloids That Inhibit L-Type Voltage-Gated Ca2+ Channels

Autor: Jacinthe Frangieh, Claire Legendre, Dimitri Bréard, Pascal Richomme, Daniel Henrion, Ziad Fajloun, César Mattei, Anne-Marie Le Ray, Christian Legros

Publikováno v: Future Pharmacology
Future Pharmacology, 2022, 2 (3), pp.238-255. ⟨10.3390/futurepharmacol2030016⟩
Future Pharmacology; Volume 2; Issue 3; Pages: 238-255

International audience; The isoquinoline alkaloids (IAs) represent a large and diverse subfamily of phytochemicals in terms of structures and pharmacological activities, including ion channel inhibition. Several IAs, such as liriodenine (an oxoaporph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2a2f5789099c41b82f09cc3558bf529
https://doi.org/10.3390/futurepharmacol2030016

Channelopathies of voltage-gated L-type Cav1.3/α1D and T-type Cav3.1/α1G Ca2+ channels in dysfunction of heart automaticity

Autor: Matteo E. Mangoni, Angelo G. Torrente, P. Mesirca, Isabelle Bidaud

Publikováno v: Pflügers Archiv European Journal of Physiology
Pflügers Archiv European Journal of Physiology, 2020, 472 (7), pp.817-830. ⟨10.1007/s00424-020-02421-1⟩
Pflügers Archiv European Journal of Physiology, Springer Verlag, 2020, 472 (7), pp.817-830. ⟨10.1007/s00424-020-02421-1⟩

International audience; The heart automaticity is a fundamental physiological function in vertebrates. The cardiac impulse is generated in the sinus node by a specialized population of spontaneously active myocytes known as "pacemaker cells." Failure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfcc3f6ae01d23be6b754272c489b179
https://doi.org/10.1007/s00424-020-02421-1

Synaptic Release Potentiation at Aging Auditory Ribbon Synapses

Autor: Peineau, Thibault, Belleudy, Séverin, Pietropaolo, Susanna, Bouleau, Yohan, Dulon, Didier

Publikováno v: Frontiers in Aging Neuroscience
Frontiers in Aging Neuroscience, Frontiers, 2021, 13, ⟨10.3389/fnagi.2021.756449⟩
Frontiers in Aging Neuroscience, 2021, 13, ⟨10.3389/fnagi.2021.756449⟩

International audience; Age-related hidden hearing loss is often described as a cochlear synaptopathy that results from a progressive degeneration of the inner hair cell (IHC) ribbon synapses. The functional changes occurring at these synapses during

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5eaa5ddbca8032d4986350e471df06e1

Inhibition of Small-Conductance Calcium-Activated Potassium Current (IK,Ca) Leads to Differential Atrial Electrophysiological Effects in a Horse Model of Persistent Atrial Fibrillation

Autor: Merle Friederike Fenner, Giulia Gatta, Stefan Sattler, Marion Kuiper, Eva Melis Hesselkilde, Ditte M. T. Adler, Morten Smerup, Ulrich Schotten, Ulrik Sørensen, Jonas Goldin Diness, Thomas Jespersen, Sander Verheule, Arne Van Hunnik, Rikke Buhl

Publikováno v: Fenner, M F, Gatta, G, Sattler, S, Kuiper, M, Hesselkilde, E M, Adler, D M T, Smerup, M, Schotten, U, Sørensen, U, Diness, J G, Jespersen, T, Verheule, S, Van Hunnik, A & Buhl, R 2021, ' Inhibition of Small-Conductance Calcium-Activated Potassium Current (I K,Ca ) Leads to Differential Atrial Electrophysiological Effects in a Horse Model of Persistent Atrial Fibrillation ', Frontiers in Physiology, vol. 12, 614483 . https://doi.org/10.3389/fphys.2021.614483
Frontiers in physiology, 12:614483. Frontiers Media S.A.
Frontiers in Physiology, Vol 12 (2021)

BackgroundSmall-conductance Ca2+-activated K+ (KCa2) channels have been proposed as a possible atrial-selective target to pharmacologically terminate atrial fibrillation (AF) and to maintain sinus rhythm. However, it has been hypothesized that the im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::078ba96875c74f9b0cdc6e7d00df0f0e
https://doi.org/10.3389/fphys.2021.614483