Botulinum neurotoxin serotype A inhibited ocular angiogenesis through modulating glial activation via SOCS3.

Autor: Gregg AT; Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Wang T; Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Szczepan M; Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Lam E; Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Yagi H; Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Neilsen K; Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Wang X; Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Smith LEH; Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA. lois.smith@childrens.harvard.edu., Sun Y; Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA. ye.sun@childrens.harvard.edu.

Publikováno v: Angiogenesis [Angiogenesis] 2024 Nov; Vol. 27 (4), pp. 753-764. Date of Electronic Publication: 2024 Jun 26.

De novo design of miniprotein antagonists of cytokine storm inducers.

Autor: Huang B; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Department of Bioengineering, University of Washington, Seattle, WA, USA., Coventry B; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA., Borowska MT; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Arhontoulis DC; Molecular and Cellular Biology and Pathobiology Program, Medical University of South Carolina, Charleston, SC, USA., Exposit M; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Abedi M; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Jude KM; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.; Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA, USA., Halabiya SF; Institute for Protein Design, University of Washington, Seattle, WA, USA., Allen A; Institute for Protein Design, University of Washington, Seattle, WA, USA., Cordray C; Institute for Protein Design, University of Washington, Seattle, WA, USA., Goreshnik I; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA., Ahlrichs M; Institute for Protein Design, University of Washington, Seattle, WA, USA., Chan S; Institute for Protein Design, University of Washington, Seattle, WA, USA., Tunggal H; Department of Microbiology, University of Washington, Seattle, WA, USA., DeWitt M; Institute for Protein Design, University of Washington, Seattle, WA, USA., Hyams N; Department of Bioengineering, Clemson University, Charleston, SC, USA., Carter L; Institute for Protein Design, University of Washington, Seattle, WA, USA., Stewart L; Institute for Protein Design, University of Washington, Seattle, WA, USA., Fuller DH; Department of Microbiology, University of Washington, Seattle, WA, USA., Mei Y; Molecular and Cellular Biology and Pathobiology Program, Medical University of South Carolina, Charleston, SC, USA.; Department of Bioengineering, Clemson University, Charleston, SC, USA., Garcia KC; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.; Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA, USA.; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA., Baker D; Department of Biochemistry, University of Washington, Seattle, WA, USA. dabaker@uw.edu.; Department of Bioengineering, University of Washington, Seattle, WA, USA. dabaker@uw.edu.; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA. dabaker@uw.edu.

Publikováno v: Nature communications [Nat Commun] 2024 Aug 16; Vol. 15 (1), pp. 7064. Date of Electronic Publication: 2024 Aug 16.

IL4Rα and IL17A Blockade Rescue Autoinflammation in SOCS1 Haploinsufficiency.

Autor: Gruber C; Center for Inborn Errors of Immunity, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Lee A; Center for Inborn Errors of Immunity, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Buta S; Center for Inborn Errors of Immunity, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Khattri S; Department of Dermatology, Icahn School of Medicine at Mount Sinai Hospital, New York, NY, USA., Gottlieb AB; Department of Dermatology, Icahn School of Medicine at Mount Sinai Hospital, New York, NY, USA., Frost JM; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai Hospital, New York, NY, USA., Bowcock AM; Department of Dermatology, Icahn School of Medicine at Mount Sinai Hospital, New York, NY, USA.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai Hospital, New York, NY, USA.; Department of Genetics & Genomics, Icahn School of Medicine at Mount Sinai Hospital, New York, NY, USA., Ho HE; Division of Clinical Immunology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Bogunovic D; Center for Inborn Errors of Immunity, Icahn School of Medicine at Mount Sinai, New York, NY, USA. dusan.bogunovic@mssm.edu.; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA. dusan.bogunovic@mssm.edu.; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. dusan.bogunovic@mssm.edu.; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. dusan.bogunovic@mssm.edu.; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. dusan.bogunovic@mssm.edu.

Publikováno v: Journal of clinical immunology [J Clin Immunol] 2023 Dec 29; Vol. 44 (1), pp. 36. Date of Electronic Publication: 2023 Dec 29.

The Human GP130 Cytokine Receptor and Its Expression-an Atlas and Functional Taxonomy of Genetic Variants.

Autor: Chen YH; Translational Gastroenterology Unit, University of Oxford, Oxford, UK., van Zon S; Translational Gastroenterology Unit, University of Oxford, Oxford, UK., Adams A; Translational Gastroenterology Unit, University of Oxford, Oxford, UK., Schmidt-Arras D; Department of Biosciences and Medical Biology, University of Salzburg, Salzburg, Austria., Laurence ADJ; Translational Gastroenterology Unit, University of Oxford, Oxford, UK., Uhlig HH; Translational Gastroenterology Unit, University of Oxford, Oxford, UK. holm.uhlig@ndm.ox.ac.uk.; Biomedical Research Centre, University of Oxford, Oxford, UK. holm.uhlig@ndm.ox.ac.uk.; Department of Paediatrics, University of Oxford, Oxford, UK. holm.uhlig@ndm.ox.ac.uk.

Publikováno v: Journal of clinical immunology [J Clin Immunol] 2023 Dec 22; Vol. 44 (1), pp. 30. Date of Electronic Publication: 2023 Dec 22.

Gp130-HIF1α axis-induced vascular damage is prevented by the short-term inhibition of IL-6 receptor signaling.

Autor: Kang S; Department of Immune Regulation, Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan.; Department of Immune Regulation, Center for Infectious Disease Education and Research, Osaka University, Suita, Osaka 565-0871, Japan., Onishi S; Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan., Ling Z; Department of Immune Regulation, Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan., Inoue H; Department of Immune Regulation, Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan., Zhang Y; Department of Immune Regulation, Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan., Chang H; Department of Immune Regulation, Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan., Zhao H; Department of Immune Regulation, Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan., Wang T; Department of Immune Regulation, Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan., Okuzaki D; Next Generation-Sequencing Core Facility, Bioinformatics Center, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan., Matsuura H; Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan., Takamatsu H; Department of Clinical Research Center for Autoimmune Disease, Osaka Minami Medical Center, National Hospital Organization, Kawachinagano, Osaka 586-8521, Japan.; Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan., Oda J; Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan., Kishimoto T; Department of Immune Regulation, Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan.; Department of Immune Regulation, Center for Infectious Disease Education and Research, Osaka University, Suita, Osaka 565-0871, Japan.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Jan 09; Vol. 121 (2), pp. e2315898120. Date of Electronic Publication: 2024 Jan 02.