Crystal structures and atomic model of NADPH oxidase

Autor: Marco W. Fraaije, Simone Nenci, Andrea Mattevi, Marta Ceccon, Elvira Romero, Francesca Magnani, Elisa Millana Fananas

Publikováno v: Proceedings of the National Academy of Science of the United States of America, 114(26), 6764-6769. NATL ACAD SCIENCES

NADPH oxidases (NOXs) are the only enzymes exclusively dedicated to reactive oxygen species (ROS) generation. Dysregulation of these polytopic membrane proteins impacts the redox signaling cascades that control cell proliferation and death. We descri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df0ab45317d0bc95faf3aff3453a907f
https://doi.org/10.1073/pnas.1702293114

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Functional analysis of two-amino acid substitutions in gp91 phox in a patient with X-linked flavocytochrome b558-positive chronic granulomatous disease by means of transgenic PLB-985 cells

Autor: Françoise Morel, Clara Bionda, Robin van Bruggen, Marie José Stasia, Xing Jun Li, Michel H.M. Eppink, Dirk Roos

Publikováno v: Human genetics, 115(5), 418-427. Springer Verlag
Human Genetics 115 (2004)
Human Genetics, 115, 418-427

Chronic granulomatous disease (CGD) is a rare inherited disorder in which phagocytes lack NADPH oxidase activity. The most common form is caused by mutations in the CYBB gene encoding gp91 phox protein, the heavy chain of cytochrome b(558), which is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58dae499bfc330158ced31dae175ac0f
https://doi.org/10.1007/s00439-004-1173-z

Identification of NOX2 regions for normal biosynthesis of cytochrome b558 in phagocytes highlighting essential residues for p22phox binding

Autor: Franck Fieschi, Sylvain Beaumel, Marie José Stasia, Didier Grunwald

Publikováno v: Biochemical Journal
Biochemical Journal, 2014, 464 (3), pp.425-37. ⟨10.1042/BJ20140555⟩
Biochemical Journal, Portland Press, 2014, 464 (3), pp.425-37. ⟨10.1042/BJ20140555⟩

International audience; Cytochrome b558, the redox core of the NADPH oxidase (NOX) complex in phagocytes, is composed of NOX2 and p22phox, the synthesis of which is intimately connected but not fully understood. We reproduced 10 rare X-minus chronic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b1f107a7028edd21847ee762b2dbd1f
https://hal.univ-grenoble-alpes.fr/hal-01130593/document

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