Zobrazeno 1 - 10
of 1 281
pro vyhledávání: '"CYS-LOOP RECEPTORS"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 18, p 10142 (2024)
Type-A γ-aminobutyric acid (GABAA) receptors are channel proteins crucial to mediating neuronal balance in the central nervous system (CNS). The structure of GABAA receptors allows for multiple binding sites and is key to drug development. Yet the f
Externí odkaz:
https://doaj.org/article/4b4bb14bc1cc43c9bf9e4a6064a3a68d
Akademický článek
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Autor:
Claude Rispe, Caroline Hervet, Nathalie de la Cotte, Romain Daveu, Karine Labadie, Benjamin Noel, Jean-Marc Aury, Steeve Thany, Emiliane Taillebois, Alison Cartereau, Anaïs Le Mauff, Claude L. Charvet, Clément Auger, Elise Courtot, Cédric Neveu, Olivier Plantard
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-20 (2022)
Abstract Background Ticks represent a major health issue for humans and domesticated animals. Exploring the expression landscape of the tick’s central nervous system (CNS), known as the synganglion, would be an important step in understanding tick
Externí odkaz:
https://doaj.org/article/6ae8842d68de43129148d3c689b663d4
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Endocannabinoids (eCBS) are endogenously derived lipid signaling molecules that serve as tissue hormones and interact with multiple targets, mostly within the endocannabinoid system (ECS). The ECS is a highly conserved regulatory system involved in h
Externí odkaz:
https://doaj.org/article/403c27d88cd846ad809bd13f38daf2b9
Autor:
Ayla Arslan
Publikováno v:
Journal of Integrative Neuroscience, Vol 20, Iss 1, Pp 173-184 (2021)
γ-Aminobutyric acid type A receptors (GABAARs) are GABA gated heteropentameric chloride channels responsible for the adult brain’s primary inhibition. In specific brain cells, such as in the hippocampus, one of the subtypes of GABAARs, the δ subu
Externí odkaz:
https://doaj.org/article/6ff5f4b6e105407fb3902d1a9c3ec4b9
Autor:
Filip Koniuszewski, Florian D. Vogel, Konstantina Bampali, Jure Fabjan, Thomas Seidel, Petra Scholze, Philip B. Schmiedhofer, Thierry Langer, Margot Ernst
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Background: Human pentameric ligand-gated ion channels (pLGICs) comprise nicotinic acetylcholine receptors (nAChRs), 5-hydroxytryptamine type 3 receptors (5-HT3Rs), zinc-activated channels (ZAC), γ-aminobutyric acid type A receptors (GABAARs) and gl
Externí odkaz:
https://doaj.org/article/dc54f068c3bd491a9c80831d692e9b36
Publikováno v:
Journal of Integrative Neuroscience, Vol 18, Iss 4, Pp 341-350 (2019)
The γ-Aminobutyric acid type A receptors (GABAARs) are heteropentameric chloride channels responsible for primary inhibition in the mammalian brain. Studies have shown the expression of recombinant GABAAR subunits tagged with the green fluorescent p
Externí odkaz:
https://doaj.org/article/4a57e44d59d34e399d6c6f81b1606590
Autor:
Ralph H. Loring
Publikováno v:
Molecules, Vol 27, Iss 14, p 4527 (2022)
The process of how multimeric transmembrane proteins fold and assemble in the endoplasmic reticulum is not well understood. The alpha7 nicotinic receptor (α7 nAChR) is a good model for multimeric protein assembly since it has at least two independen
Externí odkaz:
https://doaj.org/article/2fabbcbf4e88407aa7c79fc471b4e6c9
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Pentameric ligand-gated ion channels (pLGICs) mediate fast synaptic transmission and are crucial drug targets. Their gating mechanism is triggered by ligand binding in the extracellular domain that culminates in the opening of a hydrophobic gate in t
Externí odkaz:
https://doaj.org/article/510b7435334741cea2c5c6ec00efd983
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Externí odkaz:
https://doaj.org/article/8514649968c9420aa86b4cbb9e674d2b