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Akademický článek

Bile acids attenuate hepatic inflammation during ischemia/reperfusion injury

Autor: Kunpeng Huang, Changyan Wang, Bosheng Mei, Jinglei Li, Tianxing Ren, Hanjing Zhan, Yunwei Zhang, Bowen Zhang, Xinyu Lv, Qi Zhang, Yong Guan, Xiaofei Zhang, Guoliang Wang, Wenming Pan, Peng Xu, Hui Wang, Jinxiang Zhang

Publikováno v: JHEP Reports, Vol 6, Iss 8, Pp 101101- (2024)

Background & Aims: Persistent cholestasis has been associated with poor prognosis after orthotopic liver transplantation. In this study, we aimed to investigate how the accumulation of tauro-beta-muricholic acid (TβMCA), resulting from the reprogram

Externí odkaz: https://doaj.org/article/24b0a74732b7478aa5c3e5f33c355d5f

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Akademický článek

Combining ASBT inhibitor and FGF15 treatments enhances therapeutic efficacy against cholangiopathy in female but not male Cyp2c70 KO mice

Autor: Mohammad Nazmul Hasan, Jianglei Chen, David Matye, Huaiwen Wang, Wenyi Luo, Lijie Gu, Yung Dai Clayton, Yanhong Du, Tiangang Li

Publikováno v: Journal of Lipid Research, Vol 64, Iss 3, Pp 100340- (2023)

Therapeutic reduction of hydrophobic bile acids exposure is considered beneficial in cholestasis. The Cyp2c70 KO mice lack hydrophilic muricholic acids and have a human-like hydrophobic bile acid pool resulting in hepatobiliary injury. This study inv

Externí odkaz: https://doaj.org/article/897440a21bd44797a0f914ca459f29f9

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Akademický článek

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Akademický článek

Glycine-β-Muricholic Acid Improves Liver Fibrosis and Gut Barrier Function by Reducing Bile Acid Pool Size and Hydrophobicity in Male Cyp2c70 Knockout Mice

Autor: Mohammad Nazmul Hasan, Jianglei Chen, Huaiwen Wang, Yanhong Du, Yung Dai Clayton, Lijie Gu, Tiangang Li

Publikováno v: Cells, Vol 12, Iss 10, p 1371 (2023)

Cyp2c70 knockout mice lack the enzyme that produces muricholic acids and show a “human-like” hydrophobic bile acid pool-induced hepatobiliary injury. In this study, we investigated the potential anti-cholestasis effect of glycine-conjugated β mu

Externí odkaz: https://doaj.org/article/0057211fb2294a19860c3bdebc5e0b6b

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Akademický článek

Of mice and men: murine bile acids explain species differences in the regulation of bile acid and cholesterol metabolism[S]

Autor: Sara Straniero, Amit Laskar, Christina Savva, Jennifer Härdfeldt, Bo Angelin, Mats Rudling

Publikováno v: Journal of Lipid Research, Vol 61, Iss 4, Pp 480-491 (2020)

Compared with humans, rodents have higher synthesis of cholesterol and bile acids (BAs) and faster clearance and lower levels of serum LDL-cholesterol. Paradoxically, they increase BA synthesis in response to bile duct ligation (BDL). Another differe

Externí odkaz: https://doaj.org/article/da249c4ad2704e6e8aa69b69b72474f2

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Akademický článek

Regulation of bile acid metabolism in mouse models with hydrophobic bile acid composition

Autor: Akira Honda, Teruo Miyazaki, Junichi Iwamoto, Takeshi Hirayama, Yukio Morishita, Tadakuni Monma, Hajime Ueda, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Tadashi Ikegami

Publikováno v: Journal of Lipid Research, Vol 61, Iss 1, Pp 54-69 (2020)

The bile acid (BA) composition in mice is substantially different from that in humans. Chenodeoxycholic acid (CDCA) is an end product in the human liver; however, mouse Cyp2c70 metabolizes CDCA to hydrophilic muricholic acids (MCAs). Moreover, in hum

Externí odkaz: https://doaj.org/article/b6ca2ce2cff4472a9322001da895e681

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Akademický článek

Low production of 12α-hydroxylated bile acids prevents hepatic steatosis in Cyp2c70−/− mice by reducing fat absorption

Autor: Rumei Li, Anna Palmiotti, Hilde D. de Vries, Milaine V. Hovingh, Martijn Koehorst, Niels L. Mulder, Yue Zhang, Kim Kats, Vincent W. Bloks, Jingyuan Fu, Henkjan J. Verkade, Jan Freark de Boer, Folkert Kuipers

Publikováno v: Journal of Lipid Research, Vol 62, Iss , Pp 100134- (2021)

Bile acids (BAs) play important roles in lipid homeostasis, and BA signaling pathways serve as therapeutic targets for nonalcoholic fatty liver disease (NAFLD). Recently, we generated cytochrome P450, family 2, subfamily C, polypeptide 70 (Cyp2c70−

Externí odkaz: https://doaj.org/article/f8cb60c473764338b6419affd52446ef

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Upregulation of Taurine Biosynthesis and Bile Acid Conjugation with Taurine through FXR in a Mouse Model with Human-like Bile Acid Composition

Autor: Honda, Teruo Miyazaki, Hajime Ueda, Tadashi Ikegami, Akira

Publikováno v: Metabolites; Volume 13; Issue 7; Pages: 824

Taurine, the end product in the sulfur-containing amino acid pathway, is conjugated with bile acids (BAs) in the liver. The rate-limiting enzymes in both taurine synthesis and BA conjugation may be regulated by a nucleus receptor, FXR, that promotes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::c9584926c055e5826882bb3cd29a978b

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Akademický článek

Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans[S]

Autor: Shogo Takahashi, Tatsuki Fukami, Yusuke Masuo, Chad N. Brocker, Cen Xie, Kristopher W. Krausz, C. Roland Wolf, Colin J. Henderson, Frank J. Gonzalez

Publikováno v: Journal of Lipid Research, Vol 57, Iss 12, Pp 2130-2137 (2016)

Bile acids are synthesized from cholesterol in the liver and subjected to multiple metabolic biotransformations in hepatocytes, including oxidation by cytochromes P450 (CYPs) and conjugation with taurine, glycine, glucuronic acid, and sulfate. Mice a

Externí odkaz: https://doaj.org/article/b492e5b921554905ba4d7d1bcb88606c

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