Zobrazeno 1 - 10
of 16
pro vyhledávání: '"CYP121A1"'
Autor:
Mitali Jasani, Laxman Patel
Publikováno v:
Results in Chemistry, Vol 5, Iss , Pp 100739- (2023)
Discovering new drugs with novel targets is vital for the success of treatment of tuberculosis as antibiotic resistance is increasing among the TB population. Mycobacterium tuberculosis cytochrome P450 CYP121A1 is a promising drug target for the trea
Externí odkaz:
https://doaj.org/article/26cfa7f5f57e4b6b8f21e93159078f4a
Akademický článek
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Publikováno v:
The Journal of Biological Chemistry
Cytochromes P450 are versatile enzymes that function in endobiotic and xenobiotic metabolism and undergo meaningful structural changes that relate to their function. However, the way in which conformational changes inform the specific recognition of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3768355ea323a5f1b25f33808bf511fa
https://doi.org/10.1016/j.jbc.2021.101287
https://doi.org/10.1016/j.jbc.2021.101287
Autor:
Samia M. Mostafa, Ismail Salama, Mohamed Gomaa, Kirsty J. McLean, Mohamed A. Helal, Safaa M. Kishk, Claire Simons, Luiz Pedro S. de Carvalho, Sakshi Sood, Andrew W. Munro
Publikováno v:
Bioorganic & Medicinal Chemistry
Kishk, S, Mclean, K, Sood, S, Helal, M, Gomaa, M, Salama, I, Mostafa, S, de Carvalho, L P, Munro, A & Simons, C 2019, ' Synthesis and Biological Evaluation of Novel cYY Analogues targeting Mycobacterium tuberculosis CYP121A1 ', Bioorganic & Medicinal Chemistry, vol. 27, no. 8, doi: 10.1016/j.bmc.2019.02.051, pp. 1546-1561 . https://doi.org/10.1016/j.bmc.2019.02.051
Kishk, S, Mclean, K, Sood, S, Helal, M, Gomaa, M, Salama, I, Mostafa, S, de Carvalho, L P, Munro, A & Simons, C 2019, ' Synthesis and Biological Evaluation of Novel cYY Analogues targeting Mycobacterium tuberculosis CYP121A1 ', Bioorganic & Medicinal Chemistry, vol. 27, no. 8, doi: 10.1016/j.bmc.2019.02.051, pp. 1546-1561 . https://doi.org/10.1016/j.bmc.2019.02.051
Graphical abstract
The rise in multidrug resistant (MDR) cases of tuberculosis (TB) has led to the need for the development of TB drugs with different mechanisms of action. The genome sequence of Mycobacterium tuberculosis (Mtb) revealed twenty
The rise in multidrug resistant (MDR) cases of tuberculosis (TB) has led to the need for the development of TB drugs with different mechanisms of action. The genome sequence of Mycobacterium tuberculosis (Mtb) revealed twenty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0dab9ab9352bf0f38c06f000a0f7ea9
https://pubmed.ncbi.nlm.nih.gov/30837169
https://pubmed.ncbi.nlm.nih.gov/30837169
Autor:
Colin Levy, Luiz Pedro S. de Carvalho, Safaa M. Kishk, Mohamed Gomaa, Kirsty J. McLean, Darren Smith, Mohamed A. Helal, Samia M. Mostafa, Jack W.D. Evans, Ismail Salama, Claire Simons, Sakshi Sood, Andrew W. Munro
Publikováno v:
Kishk, S, Mclean, K, Sood, S, Smith, D, Evans, J, Helal, M, Gomaa, M, Salama, I, Mostafa, S, de Carvalho, L P, Levy, C, Munro, A & Simons, C 2019, ' Design and synthesis of imidazole and triazole pyrazoles as Mycobacterium tuberculosis CYP121A1 inhibitors ', ChemistryOpen, vol. 8, no. 7, doi: 10.1002/open.201900227, pp. 995-1011 . https://doi.org/10.1002/open.201900227
ChemistryOpen, Vol 8, Iss 7, Pp 995-1011 (2019)
ChemistryOpen, Vol 8, Iss 7, Pp 995-1011 (2019)
The emergence of untreatable drug-resistant strains of Mycobacterium tuberculosis is a major public health problem worldwide, and the identification of new efficient treatments is urgently needed. Mycobacterium tuberculosis cytochrome P450 CYP121A1 i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02abb9f1626317a1f8c61aeaa68b243e
https://www.research.manchester.ac.uk/portal/en/publications/design-and-synthesis-of-imidazole-and-triazole-pyrazoles-as-mycobacterium-tuberculosis-cyp121a1-inhibitors(e2ca0ae2-33ba-4f59-baf3-6feced74c342).html
https://www.research.manchester.ac.uk/portal/en/publications/design-and-synthesis-of-imidazole-and-triazole-pyrazoles-as-mycobacterium-tuberculosis-cyp121a1-inhibitors(e2ca0ae2-33ba-4f59-baf3-6feced74c342).html
Autor:
Ahmed S. Aboraia, Mahmoud A. El-Gendy, Leonardo B. Marino, Hend A. A. Abd El-wahab, Colin Levy, Claire Simons, Kirsty J. McLean, Andrew W. Munro, Mauro Accietto, Hamdy M. Abdel-Rahman
Publikováno v:
El-wahab, H A A A, Accietto, M, Marino, L B, McLean, K J, Levy, C W, Abdel-Rahman, H M, El-Gendy, M A, Munro, A W, Aboraia, A S & Simons, C 2018, ' Design, synthesis and evaluation against Mycobacterium tuberculosis of azole piperazine derivatives as dicyclotyrosine (cYY) mimics ', Bioorganic and Medicinal Chemistry . https://doi.org/10.1016/j.bmc.2017.11.030
Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Made available in DSpace on 2018-12-11T16:50:40Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-01-01 Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Biot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1716793d1aa0a5f4758a3659621c24d1
https://doi.org/10.1016/j.bmc.2017.11.030
https://doi.org/10.1016/j.bmc.2017.11.030
Autor:
Madeline E. Kavanagh, Andreas Bender, Jude Chenge, Anthony G. Coyne, Andrew W. Munro, Chris Abell, Kirsty J. McLean, Azedine Zoufir
Publikováno v:
Kavanagh, M E, Chenge, J, Zoufir, A, McLean, K J, Coyne, A G, Bender, A, Munro, A W & Abell, C 2017, ' Fragment Profiling Approach to Inhibitors of the Orphan M. tuberculosis P450 CYP144A1 ', Biochemistry, vol. 56, no. 11, pp. 1559-1572 . https://doi.org/10.1021/acs.biochem.6b00954
Similarity between the ligand binding profiles of enzymes may aid functional characterization and be of greater relevance to inhibitor development than sequence similarity or structural homology. Fragment screening is an efficient approach for charac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b63653edc33317c49143b067b0ae98d6
https://pubmed.ncbi.nlm.nih.gov/28169518
https://pubmed.ncbi.nlm.nih.gov/28169518
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