Zobrazeno 1 - 10
of 177
pro vyhledávání: '"CYP, Cytochrome P450"'
The pathophysiology of rapid fluctuations in mental status associated with olanzapine: A case report
Autor:
Tyler J. Torrico
Publikováno v:
Frontiers in Psychiatry, Vol 13 (2022)
BackgroundOlanzapine toxicity is reported to be a rare but specific phenomenon characterized by rapid fluctuations between somnolence and agitation, which has been referred to as “agitation despite sedation.” A similar phenomenon is observed as a
Externí odkaz:
https://doaj.org/article/c1eb85185f394525a283f8f83e846b9e
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Coronavirus disease 2019 (COVID-19) has become a new public health crisis threatening the world. Dysregulated immune responses are the most striking pathophysiological features of patients with severe COVID-19, which can result in multiple-organ fail
Externí odkaz:
https://doaj.org/article/3c42ba64aeea45f7ac3cb5df4b64383a
Autor:
R. van Westrhenen, R. H. N. van Schaik, T. van Gelder, T. K. Birkenhager, P. R. Bakker, E. J. F. Houwink, P. M. Bet, W. J. G. Hoogendijk, M. J. M. van Weelden-Hulshof
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Effective pharmacologic treatments for psychiatric disorders are available, but their effect is limited due to patients’ genetic heterogeneity and low compliance-related to frequent adverse events. Only one third of patients respond to treatment an
Externí odkaz:
https://doaj.org/article/7598e28a637d4ebd86252e89be015fee
Autor:
Ying Luo, Jun-Yan Liu
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Eicosanoids are a class of functionally bioactive lipid mediators derived from the metabolism of long-chain polyunsaturated fatty acids (PUFAs) mediated by multiple enzymes of three main branches, including cyclooxygenases (COXs), lipoxygenases (LOXs
Externí odkaz:
https://doaj.org/article/898aa60eb09547408a2f2755467b106d
Autor:
Banrida Wahlang, Monika Thapa, Michael L. Merchant, Jian Jin, Sudhir Srivastava, Josiah E. Hardesty, Russell A. Prough, Shesh N. Rai, Matthew C. Cave, Kimberly Z. Head
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3806-3819 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Dioxin-like molecules have been associated with endocrine disruption and liver disease. To better understand aryl hydrocarbon receptor (AHR) biology, metabolic phenotyping and liver proteomics were performed in mice following ligand-activation or who
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fd0117be990219f236c36406e5afea7
https://doi.org/10.1016/j.apsb.2021.10.014
https://doi.org/10.1016/j.apsb.2021.10.014
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 7, Pp 1813-1834 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Ginsenosides are a series of glycosylated triterpenoids which belong to protopanaxadiol (PPD)-, protopanaxatriol (PPT)-, ocotillol (OCT)- and oleanane (OA)-type saponins known as active compounds of Panax genus. They are accumulated in plant roots, s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f3ebd6a887266674e75c6007dc0b127
https://doi.org/10.1016/j.apsb.2020.12.017
https://doi.org/10.1016/j.apsb.2020.12.017
Autor:
Kenneth K.W. To, Jiang Ma, Stella Chai, Chunyuan Zhang, Chun Yin, Sheng Yao, Xu Wu, Thomas Efferth, Yang Ye, Onat Kadioglu, Ge Lin
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 7, Pp 1885-1902 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 7, Pp 1885-1902 (2021)
Multidrug resistance (MDR) mediated by ATP binding cassette subfamily B member 1 (ABCB1) is significantly hindering effective cancer chemotherapy. However, currently, no ABCB1-inhibitory drugs have been approved to treat MDR cancer clinically, mainly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b10ca45cdbb87dcf2ef29e5865d5f864
https://doi.org/10.1016/j.apsb.2020.12.021
https://doi.org/10.1016/j.apsb.2020.12.021
Autor:
Yaser Pashaei
Publikováno v:
Journal of Clinical Neuroscience
Graphical abstract
The current 2019 novel coronavirus disease (COVID-19), an emerging infectious disease, is undoubtedly the most challenging pandemic in the 21st century. A total of 92,977,768 confirmed cases of COVID-19 and 1,991,289 deaths we
The current 2019 novel coronavirus disease (COVID-19), an emerging infectious disease, is undoubtedly the most challenging pandemic in the 21st century. A total of 92,977,768 confirmed cases of COVID-19 and 1,991,289 deaths we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7aeeb00bbdbf0f68ba067697dc0f5a2
https://doi.org/10.1016/j.jocn.2021.03.010
https://doi.org/10.1016/j.jocn.2021.03.010
Autor:
Shengtao Yuan, Han Luwei, Dezhen Peng, Zhiqiang Wang, Hongzhi Du, Li Sun, Zhang Xian, Zhao Liwen, Danyu Du, Ligong Lu, Meixiao Zhan, Zhibo Zhang, Yong Li
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 6, Pp 1526-1540 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Acute myeloid leukaemia (AML) is the most common form of acute leukaemia in adults, with increasing incidence with age and a generally poor prognosis. Almost 20% of AML patients express mutant isocitrate dehydrogenase 2 (mIDH2), which leads to the ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1989ebe7a9db18d2c8b52de1673685c1
http://www.sciencedirect.com/science/article/pii/S2211383521000769
http://www.sciencedirect.com/science/article/pii/S2211383521000769
Autor:
Bruce D. Hammock, A. F. S. Mello, Natalie J. Török, Fawaz G. Haj, Jun Yang, Ming-Fo Hsu, Bryan Chu, Christophe Morisseau, Jeff Cheng, Shinichiro Koike
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 3, Pp 815-830 (2021)
Cellular and molecular gastroenterology and hepatology, vol 11, iss 3
Cellular and Molecular Gastroenterology and Hepatology
Cellular and molecular gastroenterology and hepatology, vol 11, iss 3
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Alcohol-associated liver disease (ALD) is a significant cause of liver-related morbidity and mortality worldwide and with limited therapies. Soluble epoxide hydrolase (sEH; Ephx2) is a largely cytosolic enzyme that is highly express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a37aec2ab2970ef64d585a65ffea8d3
http://www.sciencedirect.com/science/article/pii/S2352345X20301624
http://www.sciencedirect.com/science/article/pii/S2352345X20301624