Zobrazeno 1 - 10
of 35 548
pro vyhledávání: '"CYCLIN DEPENDENT KINASES"'
Autor:
Pallasaho S; Department of Biochemistry and Developmental Biology, Faculty of Medicine, University of Helsinki, Helsinki 00014, Finland., Gondane A; Department of Biochemistry and Developmental Biology, Faculty of Medicine, University of Helsinki, Helsinki 00014, Finland., Kutz J; Project group Biochemistry, Leibniz Institute on Aging - Fritz Lipmann Institute, Jena D-07745, Germany., Liang J; Department of Biochemistry and Developmental Biology, Faculty of Medicine, University of Helsinki, Helsinki 00014, Finland., Yalala S; Department of Biochemistry and Developmental Biology, Faculty of Medicine, University of Helsinki, Helsinki 00014, Finland., Duveau DY; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, NIH, Rockville, MD 20850, United States., Pospiech H; Project group Biochemistry, Leibniz Institute on Aging - Fritz Lipmann Institute, Jena D-07745, Germany.; University Hospital and Medical Faculty of the Heinrich-Heine University Düsseldorf, Life Science Center, Düsseldorf D-40225, Germany., Thomas CJ; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, NIH, Rockville, MD 20850, United States.; Lymphoid Malignancies Branch, Center for Cancer Research, NCI, NIH, Bethesda, MD, United States., Loda M; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York 10021, United States.; The Broad Institute of Harvard and MIT, Cambridge, MA 02142, United States.; The New York Genome Center, New York, New York 10013, United States., Itkonen HM; Department of Biochemistry and Developmental Biology, Faculty of Medicine, University of Helsinki, Helsinki 00014, Finland.; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York 10021, United States.
Publikováno v:
Glycobiology [Glycobiology] 2024 Dec 10; Vol. 34 (12).
Autor:
Chou J; UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California.; Division of Hematology and Oncology, Department of Medicine, University of California San Francisco, San Francisco, California., Robinson TM; UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California.; Department of Radiation Oncology, University of California San Francisco, San Francisco, California., Egusa EA; UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California.; Department of Radiation Oncology, University of California San Francisco, San Francisco, California., Lodha R; UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California.; Department of Radiation Oncology, University of California San Francisco, San Francisco, California., Zhang M; UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California.; Department of Radiation Oncology, University of California San Francisco, San Francisco, California., Badura M; UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California.; Department of Radiation Oncology, University of California San Francisco, San Francisco, California., Mikayelyan M; UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California.; Department of Radiation Oncology, University of California San Francisco, San Francisco, California., Delavan HM; UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California.; Division of Hematology and Oncology, Department of Medicine, University of California San Francisco, San Francisco, California., Swinderman J; UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California.; Department of Radiation Oncology, University of California San Francisco, San Francisco, California., Wilson C; Department of Pharmaceutical Chemistry and the Small Molecule Discovery Center, University of California San Francisco, San Francisco, California., Zhu J; UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California.; Department of Radiation Oncology, University of California San Francisco, San Francisco, California., Das R; UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California.; Department of Radiation Oncology, University of California San Francisco, San Francisco, California., Nguyen M; Clovis Oncology, Inc., Boulder, Colorado., Loehr A; Clovis Oncology, Inc., Boulder, Colorado., Golsorkhi T; Clovis Oncology, Inc., Boulder, Colorado., Simmons A; Clovis Oncology, Inc., Boulder, Colorado., Abida W; Genitourinary Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York., Chinnaiyan AM; Department of Pathology, University of Michigan, Ann Arbor, Michigan.; Howard Hughes Medical Institute, University of Michigan, Ann Arbor, Michigan., Arkin MR; Department of Pharmaceutical Chemistry and the Small Molecule Discovery Center, University of California San Francisco, San Francisco, California., Small EJ; UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California.; Division of Hematology and Oncology, Department of Medicine, University of California San Francisco, San Francisco, California., Quigley DA; UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California.; Department of Urology, University of California San Francisco, San Francisco, California.; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California., Yang L; Ben May Department for Cancer Research, University of Chicago, Chicago, Illinois.; Department of Human Genetics, University of Chicago, Chicago, Illinois., Kim M; UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California.; Department of Cellular Molecular Pharmacology, University of California San Francisco, San Francisco, California.; Department of Biochemistry and Structural Biology, University of Texas Health Science Center, San Antonio, Texas., Ashworth A; UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California.; Division of Hematology and Oncology, Department of Medicine, University of California San Francisco, San Francisco, California., Feng FY; UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California.; Division of Hematology and Oncology, Department of Medicine, University of California San Francisco, San Francisco, California.; Department of Radiation Oncology, University of California San Francisco, San Francisco, California.; Department of Urology, University of California San Francisco, San Francisco, California.
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2024 Dec 02; Vol. 30 (23), pp. 5445-5458.
Autor:
Lara-Núñez A; Facultad de Química, Departamento de Bioquímica, Universidad Nacional Autónoma de México, Ciudad de México, Méxicounam.mx. Electronic address: auroraln@unam.mx., Guerrero-Molina ED; Facultad de Química, Departamento de Bioquímica, Universidad Nacional Autónoma de México, Ciudad de México, Méxicounam.mx. Electronic address: edamaris12@hotmail.com., Vargas-Cortez T; Facultad de Química, Departamento de Bioquímica, Universidad Nacional Autónoma de México, Ciudad de México, Méxicounam.mx. Electronic address: q.terev@gmail.com., Vázquez-Ramos JM; Facultad de Química, Departamento de Bioquímica, Universidad Nacional Autónoma de México, Ciudad de México, Méxicounam.mx. Electronic address: jorman@unam.mx.
Publikováno v:
Journal of plant physiology [J Plant Physiol] 2024 Dec; Vol. 303, pp. 154378. Date of Electronic Publication: 2024 Nov 06.
Autor:
Roy R; Centre for Biomedical Engineering, Indian Institute of Technology, New Delhi, 110016, India., Gampa SC; Department of Biotechnology, School of Science, GITAM (deemed to be University), Visakhapatnam, 530045, India., Garimella SV; Department of Biotechnology, School of Science, GITAM (deemed to be University), Visakhapatnam, 530045, India. Electronic address: sgarimel@gitam.edu.
Publikováno v:
Current opinion in pharmacology [Curr Opin Pharmacol] 2024 Dec; Vol. 79, pp. 102485. Date of Electronic Publication: 2024 Sep 10.
Autor:
Lu H; Insilico Medicine Shanghai Ltd, Suite 901, Tower C, Changtai Plaza, 2889 Jinke Road, Pudong New District, Shanghai 201203, China., Zhang Y; Insilico Medicine Shanghai Ltd, Suite 901, Tower C, Changtai Plaza, 2889 Jinke Road, Pudong New District, Shanghai 201203, China., Liu J; Insilico Medicine Shanghai Ltd, Suite 901, Tower C, Changtai Plaza, 2889 Jinke Road, Pudong New District, Shanghai 201203, China., Jiang T; GenFleet Therapeutics (Zhejiang) Co Ltd., Shaoxing, 312000, P.R. China., Yu X; GenFleet Therapeutics (Shanghai) Inc., Shanghai 201203, P.R. China., Zhang H; Insilico Medicine Shanghai Ltd, Suite 901, Tower C, Changtai Plaza, 2889 Jinke Road, Pudong New District, Shanghai 201203, China., Liang T; GenFleet Therapeutics (Shanghai) Inc., Shanghai 201203, P.R. China., Peng J; Insilico Medicine Shanghai Ltd, Suite 901, Tower C, Changtai Plaza, 2889 Jinke Road, Pudong New District, Shanghai 201203, China., Cai X; Insilico Medicine Shanghai Ltd, Suite 901, Tower C, Changtai Plaza, 2889 Jinke Road, Pudong New District, Shanghai 201203, China., Lan X; GenFleet Therapeutics (Shanghai) Inc., Shanghai 201203, P.R. China., Ren J; GenFleet Therapeutics (Shanghai) Inc., Shanghai 201203, P.R. China., Ge M; GenFleet Therapeutics (Shanghai) Inc., Shanghai 201203, P.R. China., Zhang J; GenFleet Therapeutics (Shanghai) Inc., Shanghai 201203, P.R. China., Shang J; GenFleet Therapeutics (Shanghai) Inc., Shanghai 201203, P.R. China., Yu J; Insilico Medicine Shanghai Ltd, Suite 901, Tower C, Changtai Plaza, 2889 Jinke Road, Pudong New District, Shanghai 201203, China., Ren H; GenFleet Therapeutics (Shanghai) Inc., Shanghai 201203, P.R. China., Liu Q; GenFleet Therapeutics (Shanghai) Inc., Shanghai 201203, P.R. China., Gao J; GenFleet Therapeutics (Shanghai) Inc., Shanghai 201203, P.R. China., Tang L; GenFleet Therapeutics (Shanghai) Inc., Shanghai 201203, P.R. China., Ding X; Insilico Medicine Shanghai Ltd, Suite 901, Tower C, Changtai Plaza, 2889 Jinke Road, Pudong New District, Shanghai 201203, China., Zhang M; Insilico Medicine Shanghai Ltd, Suite 901, Tower C, Changtai Plaza, 2889 Jinke Road, Pudong New District, Shanghai 201203, China., Aliper A; Insilico Medicine AI Limited, Masdar City, Abu Dhabi 145748, UAE., Lu Q; GenFleet Therapeutics (Shanghai) Inc., Shanghai 201203, P.R. China., Zhou F; GenFleet Therapeutics (Shanghai) Inc., Shanghai 201203, P.R. China., Lan J; GenFleet Therapeutics (Shanghai) Inc., Shanghai 201203, P.R. China., Ren F; Insilico Medicine Shanghai Ltd, Suite 901, Tower C, Changtai Plaza, 2889 Jinke Road, Pudong New District, Shanghai 201203, China., Zhavoronkov A; Insilico Medicine Shanghai Ltd, Suite 901, Tower C, Changtai Plaza, 2889 Jinke Road, Pudong New District, Shanghai 201203, China.; Insilico Medicine AI Limited, Masdar City, Abu Dhabi 145748, UAE.
Publikováno v:
Journal of medicinal chemistry [J Med Chem] 2024 Nov 28; Vol. 67 (22), pp. 20580-20594. Date of Electronic Publication: 2024 Nov 09.
Autor:
Ebara S; Department of Biological Sciences, Faculty of Science, Ibaraki University, Bunkyo 2-1-1, Mito, Ibaraki, 310-8512, Japan; Chordia Therapeutics Inc., Kanagawa, 251-0012, Japan., Yoshida M; Chordia Therapeutics Inc., Kanagawa, 251-0012, Japan., Yamakawa H; Department of Biological Sciences, Faculty of Science, Ibaraki University, Bunkyo 2-1-1, Mito, Ibaraki, 310-8512, Japan; Chordia Therapeutics Inc., Kanagawa, 251-0012, Japan., Shimokawa K; Chordia Therapeutics Inc., Kanagawa, 251-0012, Japan., Inoue Y; Department of Cell Signaling, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, 467-8603, Japan., Tauchi H; Department of Biological Sciences, Faculty of Science, Ibaraki University, Bunkyo 2-1-1, Mito, Ibaraki, 310-8512, Japan. Electronic address: hiroshi.tauchi.sci@vc.ibaraki.ac.jp., Morishita D; Chordia Therapeutics Inc., Kanagawa, 251-0012, Japan. Electronic address: daisuke.morishita.phd@gmail.com.
Publikováno v:
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2024 Nov 26; Vol. 735, pp. 150608. Date of Electronic Publication: 2024 Aug 28.
Autor:
Chen X; Research Institute, Hospital for Special Surgery, New York, NY 10021, USA.; Immunology and Microbial Pathogenesis Graduate Program, Weill Cornell Medicine, New York, NY 10065, USA., Shibu G; Research Institute, Hospital for Special Surgery, New York, NY 10021, USA.; Immunology and Microbial Pathogenesis Graduate Program, Weill Cornell Medicine, New York, NY 10065, USA., Sokolsky BA; Research Institute, Hospital for Special Surgery, New York, NY 10021, USA.; Immunology and Microbial Pathogenesis Graduate Program, Weill Cornell Medicine, New York, NY 10065, USA., Soussana TN; Research Institute, Hospital for Special Surgery, New York, NY 10021, USA., Fisher L; Research Institute, Hospital for Special Surgery, New York, NY 10021, USA.; Immunology and Microbial Pathogenesis Graduate Program, Weill Cornell Medicine, New York, NY 10065, USA., Deochand DK; Research Institute, Hospital for Special Surgery, New York, NY 10021, USA.; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY 10065, USA., Dacic M; Research Institute, Hospital for Special Surgery, New York, NY 10021, USA.; Physiology, Biophysics and Systems Biology Graduate Program, Weill Cornell Medicine, New York, NY 10065, USA., Mantel I; Research Institute, Hospital for Special Surgery, New York, NY 10021, USA.; Immunology and Microbial Pathogenesis Graduate Program, Weill Cornell Medicine, New York, NY 10065, USA., Ramirez DC; Department of Pathology and Laboratory Medicine, Hospital for Special Surgery, New York, NY 10021, USA., Bell RD; Research Institute, Hospital for Special Surgery, New York, NY 10021, USA.; David Z. Rosensweig Genomics Center, Hospital for Special Surgery, New York, NY 10021, USA., Zhang T; Department of Chemical and Systems Biology, Chem-H and Stanford Cancer Institute, Stanford School of Medicine, Stanford University, Stanford, CA 94305, USA., Donlin LT; Research Institute, Hospital for Special Surgery, New York, NY 10021, USA.; Immunology and Microbial Pathogenesis Graduate Program, Weill Cornell Medicine, New York, NY 10065, USA.; Physiology, Biophysics and Systems Biology Graduate Program, Weill Cornell Medicine, New York, NY 10065, USA., Goodman SM; Division of Rheumatology, Hospital for Special Surgery, New York, NY 10021, USA., Gray NS; Department of Chemical and Systems Biology, Chem-H and Stanford Cancer Institute, Stanford School of Medicine, Stanford University, Stanford, CA 94305, USA., Chinenov Y; Research Institute, Hospital for Special Surgery, New York, NY 10021, USA.; David Z. Rosensweig Genomics Center, Hospital for Special Surgery, New York, NY 10021, USA., Fisher RP; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10021, USA., Rogatsky I; Research Institute, Hospital for Special Surgery, New York, NY 10021, USA.; Immunology and Microbial Pathogenesis Graduate Program, Weill Cornell Medicine, New York, NY 10065, USA.; David Z. Rosensweig Genomics Center, Hospital for Special Surgery, New York, NY 10021, USA.
Publikováno v:
Science translational medicine [Sci Transl Med] 2024 Nov 20; Vol. 16 (774), pp. eadq5091. Date of Electronic Publication: 2024 Nov 20.
Autor:
Shaikh MAJ; Department of Pharmacy, TPCT's College of Engineering, Osmanabad, Maharashtra, India., Babu MA; Institute of Pharmaceutical Research, GLA UNIVERSITY, Mathura, UP 281406, India., Ghaboura N; Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al Kharj 11942, Saudi Arabia., Altamimi ASA; Department of Pharmacy Practice, Pharmacy Program, Batterjee Medical College, P. O. Box 6231, Jeddah 21442, Saudi Arabia., Sharma P; Department of Allied Healthcare and Sciences, Vivekananda Global University, Jaipur, Rajasthan 303012, India. Electronic address: pawansharma.pharma@hotmail.com., Rani R; University Centre for Research and Development, Chandigarh University, Mohali, Punjab 140413, India., Rani GB; KKR and KSR Institute of Technology and Sciences, Guntur, India., Lakhanpal S; Division of Research and Development, Lovely Professional University, Phagwara 144411, India., Ali H; Centre for Global Health Research, Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences, India; Department of Pharmacology, Kyrgyz State Medical College, Bishkek, Kyrgyzstan., Balaraman AK; Research and Enterprise, University of Cyberjaya, Persiaran Bestari, Cyber 11, Cyberjaya, Selangor 63000, Malaysia., Rawat S; Graphic Era (Deemed to be University), Clement Town, Dehradun 248002, India., Alzarea SI; Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka, Al-Jouf 72341, Saudi Arabia., Kazmi I; Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Publikováno v:
Pathology, research and practice [Pathol Res Pract] 2024 Nov; Vol. 263, pp. 155659. Date of Electronic Publication: 2024 Oct 15.
Autor:
Linhartova K; CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czechia.; National Centre for Biomolecular Research, Faculty of Science, Masaryk University, Brno, Czechia., Falginella FL; CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czechia., Matl M; CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czechia., Sebesta M; CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czechia. marek.sebesta@ceitec.muni.cz., Vácha R; CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czechia. robert.vacha@ceitec.muni.cz., Stefl R; CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czechia. richard.stefl@ceitec.muni.cz.; National Centre for Biomolecular Research, Faculty of Science, Masaryk University, Brno, Czechia. richard.stefl@ceitec.muni.cz.
Publikováno v:
Nature communications [Nat Commun] 2024 Oct 24; Vol. 15 (1), pp. 9163. Date of Electronic Publication: 2024 Oct 24.
Autor:
Zhou L; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Discovery of Chinese Ministry of Education (MOE), Guangzhou City Key Laboratory of Precision Chemical Drug Development, College of Pharmacy, Jinan University, 855 Xingye Avenue East, Guangzhou 511400, China.; State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, #345 Lingling Rd., Shanghai 200032, China., Zhou K; State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, #345 Lingling Rd., Shanghai 200032, China.; University of Chinese Academy of Sciences, No. 1 Yanxihu Road, Huairou District, Beijing 101408, China., Chang Y; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan 48109, United States.; Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, United States., Yang J; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Discovery of Chinese Ministry of Education (MOE), Guangzhou City Key Laboratory of Precision Chemical Drug Development, College of Pharmacy, Jinan University, 855 Xingye Avenue East, Guangzhou 511400, China., Fan B; State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, #345 Lingling Rd., Shanghai 200032, China., Su Y; State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, #345 Lingling Rd., Shanghai 200032, China., Li Z; State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, #345 Lingling Rd., Shanghai 200032, China., Mannan R; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan 48109, United States.; Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, United States., Mahapatra S; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan 48109, United States.; Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, United States., Ding M; School of Life Science and Technology, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211198, China., Zhou F; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Discovery of Chinese Ministry of Education (MOE), Guangzhou City Key Laboratory of Precision Chemical Drug Development, College of Pharmacy, Jinan University, 855 Xingye Avenue East, Guangzhou 511400, China., Huang W; State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, #345 Lingling Rd., Shanghai 200032, China., Ren X; State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, #345 Lingling Rd., Shanghai 200032, China., Xu J; Livzon Research Institute, Livzon Pharmaceutical Group Inc., No. 38, Chuangye North Road, Jinwan District, Zhuhai 519000, China., Wang GX; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan 48109, United States.; Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, United States.; Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, United States., Zhang J; State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, #345 Lingling Rd., Shanghai 200032, China., Wang Z; State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, #345 Lingling Rd., Shanghai 200032, China., Chinnaiyan AM; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan 48109, United States.; Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, United States.; Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, United States.; Howard Hughes Medical Institute, University of Michigan, Ann Arbor, Michigan 48109, United States.; Department of Urology, University of Michigan, Ann Arbor, Michigan 48109, United States., Ding K; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Discovery of Chinese Ministry of Education (MOE), Guangzhou City Key Laboratory of Precision Chemical Drug Development, College of Pharmacy, Jinan University, 855 Xingye Avenue East, Guangzhou 511400, China.; State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, #345 Lingling Rd., Shanghai 200032, China.
Publikováno v:
Journal of medicinal chemistry [J Med Chem] 2024 Oct 24; Vol. 67 (20), pp. 18247-18264. Date of Electronic Publication: 2024 Oct 10.