Výsledky vyhledávání - "CXCL, chemokine (C–X

Before the 'cytokine storm': Boosting efferocytosis as an effective strategy against SARS-CoV-2 infection and associated complications

Autor: Dutta, Somit, Mukherjee, Amartya, Nongthomba, Upendra

Publikováno v: Cytokine & Growth Factor Reviews

The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is responsible for the ongoing COVID-19 pandemic, and causes many health complications, including major lung diseases. Besides investigations into the virology of SARS-CoV-2, understand

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d5990459f79223696772bfb7610dedb
https://doi.org/10.1016/j.cytogfr.2022.01.002

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Small molecules targeting the innate immune cGAS‒STING‒TBK1 signaling pathway

Autor: Tingting Chen, Ancheng Shen, Ao Zhang, Chunyong Ding, Zilan Song

Publikováno v: Acta Pharmaceutica Sinica B, Vol 10, Iss 12, Pp 2272-2298 (2020)
Acta Pharmaceutica Sinica. B

Multiple cancer immunotherapies including chimeric antigen receptor T cell and immune checkpoint inhibitors (ICIs) have been successfully developed to treat various cancers by motivating the adaptive anti-tumor immunity. Particularly, the checkpoint

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c604607610f05b2d37da5b2cce00382
http://www.sciencedirect.com/science/article/pii/S2211383519316946

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Decoding the enigma of antiviral crisis: Does one target molecule regulate all?

Autor: Apurba Majumder, Abdullah Mahmud-Al-Rafat, A. M. Mahedi Hasan, K. M. Taufiqur Rahman, Andrew W. Taylor-Robinson, Morsaline Billah, K.M. Didarul Islam

Publikováno v: Cytokine

Highlights • IL-6 class switching provides regulation over pro- and anti-inflammatory responses. • Unregulated IL-6 trans-signaling promotes uncontrolled pro-inflammatory responses. • ADAM-17 regulates class switching between IL-6 trans- and cl

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http://europepmc.org/articles/PMC7129598

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An enlightening role for cytokine storm in coronavirus infection

Autor: Chuanmin Tao, Zhongyi Zhao, Yinhao Wei

Publikováno v: Clinical Immunology
Clinical Immunology (Orlando, Fla.)

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak in Wuhan, China has dispersed rapidly worldwide. Although most patients present with mild fever, cough with varying pulmonary shadows, a significant portion still develops seve

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Macrophage-derived cytokines in pneumonia: Linking cellular immunology and genetics

Autor: Anna Shtro, Marina Dukhinova, Polina Kuchur, Elena Kokinos, Alexey Komissarov

Publikováno v: Cytokine & Growth Factor Reviews

Graphical abstract
Macrophages represent the first line of anti-pathogen defense - they encounter invading pathogens to perform the phagocytic activity, to deliver the plethora of pro- and anti-inflammatory cytokines, and to shape the tissue mic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3a702ed645dea7807089e0c4d5edaae
https://pubmed.ncbi.nlm.nih.gov/33342718

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SARS-CoV-2 and helminth co-infections, and environmental pollution exposure: An epidemiological and immunological perspective

Autor: Roxanne Pillay, Nomzamo Nembe, Zamathombeni Duma, Rajen N. Naidoo, Miranda N. Mpaka-Mbatha, Ravesh Singh, Pragalathan Naidoo, Zilungile L. Mkhize-Kwitshana, Veron Ramsuran, Terisha Ghazi, Khethiwe N. Bhengu, Anil A. Chuturgoon

Publikováno v: Environment International
Environment International, Vol 156, Iss, Pp 106695-(2021)

Soil-transmitted helminths infect billions of people globally, particularly those residing in low- and middle-income regions with poor environmental sanitation and high levels of air and water pollution. Helminths display potent immunomodulatory acti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eba13a29c256e957fb5ca4f051ffe93d
http://europepmc.org/articles/PMC8205275

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Hepatocyte Toll-Like Receptor 5 Promotes Bacterial Clearance and Protects Mice Against High-Fat Diet–Induced Liver Disease

Autor: Andrew T. Gewirtz, Matam Vijay-Kumar, Lucie Etienne-Mesmin, Benoit Chassaing

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 2, Iss 5, Pp 584-604 (2016)
Cellular and Molecular Gastroenterology and Hepatology

Background & Aims: Innate immune dysfunction can promote chronic inflammatory diseases of the liver. For example, mice lacking the flagellin receptor Toll-like receptor 5 (TLR5) show microbial dysbiosis and predisposition to high-fat diet (HFD)-induc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::983f60a89bc033c3b6ac4a6d24c6eaef

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Proprotein convertase 1/3 inhibited macrophages: A novel therapeutic based on drone macrophages

Autor: Michel Salzet, Adriana Murgoci, Robert Day, Isabelle Fournier, Franck Rodet, Marie Duhamel, Maxence Wisztorski

Publikováno v: EuPA Open Proteomics, Vol 11, Iss C, Pp 20-22 (2016)
EuPA Open Proteomics

Graphical abstract Schematic depicting how PC1/3 knockdown impacts macrophage activation based on the data presented.
Highlights • Proprotein convertase 1/3 knockdown or knockout macrophages present all the characteristic of activated pro-infl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a5511a1e46f49dc26553c4ec0f3daeb
http://www.sciencedirect.com/science/article/pii/S2212968516300204

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Enhanced Immunosuppressive Properties of Human Mesenchymal Stem Cells Primed by Interferon-γ

Autor: Ji Won Lee, Keon Hee Yoo, Dae Seong Kim, Young Jong Ko, Hong Hoe Koo, Ki Woong Sung, In Keun Jang, Myoung Woo Lee, Doo-Hoon Lee

Publikováno v: EBioMedicine
EBioMedicine, Vol 28, Iss C, Pp 261-273 (2018)

Mesenchymal stem cells (MSCs) are of particular interest for the treatment of immune-related diseases owing to their immunosuppressive properties. In this study, we aimed to identify the effect of interferon (IFN)-γ priming on immunomodulation by MS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52cfd915540d178a830c44f317b1e53a
https://pubmed.ncbi.nlm.nih.gov/29366627

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Neurons under viral attack: Victims or warriors?

Autor: Anirban Basu, Kallol Dutta, Swarupa Chakraborty, Arshed Nazmi

Publikováno v: Neurochemistry International

When the central nervous system (CNS) is under viral attack, defensive antiviral responses must necessarily arise from the CNS itself to rapidly and efficiently curb infections with minimal collateral damage to the sensitive, specialized and non-rege

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f477ebf1739590649d0c5f85af1a58c7
http://europepmc.org/articles/PMC7115389

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