Pharmacological depletion of microglia alleviates neuronal and vascular damage in the diabetic CX3CR1-WT retina but not in CX3CR1-KO or hCX3CR1I249/M280-expressing retina

Autor: Kaira A. Church, Derek Rodriguez, Andrew S. Mendiola, Difernando Vanegas, Irene L. Gutierrez, Ian Tamayo, Abdul Amadu, Priscila Velazquez, Sandra M. Cardona, Stefka Gyoneva, Anne C. Cotleur, Richard M. Ransohoff, Tejbeer Kaur, Astrid E. Cardona

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

Diabetic retinopathy, a microvascular disease characterized by irreparable vascular damage, neurodegeneration and neuroinflammation, is a leading complication of diabetes mellitus. There is no cure for DR, and medical interventions marginally slow th

Externí odkaz: https://doaj.org/article/2061e61566104f23b60844866d5b9d5b

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Intrinsic Gastrointestinal Macrophages: Their Phenotype and Role in Gastrointestinal Motility

Autor: Gianluca Cipriani, Simon J. Gibbons, Gianrico Farrugia, Purna C. Kashyap

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 2, Iss 2, Pp 120-130.e1 (2016)

There is an increasing awareness of the role of macrophages in the regulation and maintenance of gastrointestinal function in health and disease. This work has proceeded in the context of an increased understanding of the complex phenotypic variation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91a008dd70ca7ea7189873d459c3354d