Insights into the role of the von Hippel-Lindau gene product. A key player in hypoxic regulation

Autor: Ph, Maxwell, Cw, Pugh, Peter Ratcliffe

Publikováno v: Europe PubMed Central

Many adaptive responses to hypoxia involve changes in gene transcription mediated by the hypoxia-inducible factor 1 complex. Central to this is oxygen-dependent proteolysis of the alpha subunit, which has recently been shown to require the von Hippel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::1aab94b002590ef0aa064db77892b311
https://pubmed.ncbi.nlm.nih.gov/11423722

Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha

Autor: Ms, Wiesener, Turley H, We, Allen, Willam C, Ku, Eckardt, Kl, Talks, Sm, Wood, Kc, Gatter, Al, Harris, Cw, Pugh, Peter Ratcliffe, Ph, Maxwell

Publikováno v: Europe PubMed Central

Hypoxia results in adaptive changes in the transcription of a range of genes including erythropoietin. An important mediator is hypoxia-inducible factor-1 (HIF-1), a DNA binding complex shown to contain at least two basic helix-loop-helix PAS-domain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7eecf9de16704287ec59f734b84d0c2f
https://pubmed.ncbi.nlm.nih.gov/9746763

The HIF pathway: implications for patterns of gene expression in cancer

Autor: Cc, Wykoff, Cw, Pugh, Al, Harris, Ph, Maxwell, Peter Ratcliffe

Publikováno v: Europe PubMed Central

Regulation of the growth and metabolism of large organisms is tightly constrained by the need for precise oxygen homeostasis. Work on control of the haematopoietic growth factor erythropoietin has led to the recognition of a widespread transcriptiona

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::13c2ce11059e515cee82e4b562e0cccb
http://europepmc.org/abstract/med/11727931

Mutation of the von Hippel-Lindau gene alters human cardiopulmonary physiology

Autor: Tg, Smith, Jt, Brooks, Gm, Balanos, Tr, Lappin, Dm, Layton, Dl, Leedham, Liu C, Ph, Maxwell, Mf, Mcmullin, Cj, Mcnamara, Mj, Percy, Cw, Pugh, Pj, Ratcliffe, Np, Talbot, Treacy M, Peter Robbins

Publikováno v: Europe PubMed Central

Intracellular responses to hypoxia are coordinated by the von Hippel-Lindau--hypoxia-inducible factor (VHL-HIF) transcriptional system. This study investigated the potential role of the VHL-HIF pathway in human systems-level physiology. Patients diag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::594bb6cbd9abe932f262033cb3adfda3
http://europepmc.org/abstract/med/18085246

Oncogenic Cell Tagging and Single-Cell Transcriptomics Reveal Cell Type-Specific and Time-Resolved Responses to Vhl Inactivation in the Kidney.

Autor: Kurlekar S; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.; Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Lima JDCC; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.; Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Li R; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Lombardi O; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Masson N; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.; Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Barros AB; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.; Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Pontecorvi V; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.; Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Mole DR; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Pugh CW; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Adam J; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.; Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Ratcliffe PJ; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.; Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.; The Francis Crick Institute, 1 Midland Road, London, United Kingdom.

Publikováno v: Cancer research [Cancer Res] 2024 Jun 04; Vol. 84 (11), pp. 1799-1816.