Natriuretic Peptide Receptor-C Protects Against Angiotensin II-Mediated Sinoatrial Node Disease in Mice

Autor: Oleg Bogachev, Sara A. Rafferty, Yingjie Liu, Rui Hua, Hailey J. Jansen, Megan D. McRae, Motahareh Moghtadaei, Robert A. Rose, Adam W. Kirkby, Jaspreet Kaur, Gibanananda Ray, Emmanuel E. Egom, Martin Mackasey

Publikováno v: JACC: Basic to Translational Science, Vol 3, Iss 6, Pp 824-843 (2018)
JACC: Basic to Translational Science

Visual Abstract
Highlights • SAN disease is prevalent in hypertension and heart failure and can be induced by chronic Ang II treatment in mice. • Ang II caused SAN disease in mice in association with impaired electrical conduction, reduction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68cdb596fe58db99fec50a0640c1d6ed
http://www.sciencedirect.com/science/article/pii/S2452302X18302237

An automated system using spatial oversampling for optical mapping in murine atria. Development and validation with monophasic and transmembrane action potentials

Autor: Benjamin Osborne, Paulus Kirchhof, Ting Y. Yu, Fahima Syeda, Keith L. Brain, Hamid Dehghani, Andrew P. Holmes, Larissa Fabritz

Publikováno v: Progress in Biophysics and Molecular Biology

We developed and validated a new optical mapping system for quantification of electrical activation and repolarisation in murine atria. The system makes use of a novel 2nd generation complementary metal-oxide-semiconductor (CMOS) camera with delibera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11cdb73a7677dac5288020c2c5df0819
https://doi.org/10.1016/j.pbiomolbio.2014.07.012

Regulation of alternative VEGF-A mRNA splicing is a therapeutic target for analgesia

Autor: Hulse, RP, Beazley-Long, N, Hua, J, Kennedy, H, Prager, J, Bevan, H, Qiu, Y, Fernandes, ES, Gammons, MV, Ballmer-Hofer, K, Gittenberger de Groot, AC, Churchill, AJ, Harper, SJ, Brain, SD, Bates, DO, Donaldson, LF

Publikováno v: Neurobiology of Disease
Neurobiology of disease
Neurobiology of Disease, Vol 71, Iss, Pp 245-259 (2014)

Vascular endothelial growth factor-A (VEGF-A) is best known as a key regulator of the formation of new blood vessels. Neutralization of VEGF-A with anti-VEGF therapy e.g. bevacizumab, can be painful, and this is hypothesized to result from a loss of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7fa2bec7cc98cb18599b1a718cb8f5cf
https://pubmed.ncbi.nlm.nih.gov/25151644

Enhancement of Gap Junction Function During Acute Myocardial Infarction Modifies Healing and Reduces Late Ventricular Arrhythmia Susceptibility

Autor: Ng, Fu Siong, Kalindjian, Jeremy M., Cooper, Simon A., Chowdhury, Rasheda A., Patel, Pravina M., Dupont, Emmanuel, Lyon, Alexander R., Peters, Nicholas S.

Publikováno v: JACC: Clinical Electrophysiology. (5):574-582

ObjectivesThe purpose of this study was to investigate the effects of enhancing gap junction (GJ) coupling during acute myocardial infarction (MI) on the healed infarct scar morphology and late post-MI arrhythmia susceptibility.BackgroundIncreased he

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::12d230d610e547420f1e89f7df04f12c

Natriuretic Peptide Receptor-C Protects Against Angiotensin II-Mediated Sinoatrial Node Disease in Mice.

Autor: Mackasey M; Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada, and Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Department of Physiology and Biophysics, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada., Egom EE; Department of Physiology and Biophysics, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada., Jansen HJ; Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada, and Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Department of Physiology and Biophysics, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada., Hua R; Department of Physiology and Biophysics, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada., Moghtadaei M; Department of Physiology and Biophysics, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada., Liu Y; Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada, and Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Kaur J; Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada, and Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., McRae MD; Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada, and Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Bogachev O; Department of Physiology and Biophysics, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada., Rafferty SA; Department of Physiology and Biophysics, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada., Ray G; Department of Physiology and Biophysics, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada., Kirkby AW; Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada, and Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Rose RA; Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada, and Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Department of Physiology and Biophysics, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.

Publikováno v: JACC. Basic to translational science [JACC Basic Transl Sci] 2018 Dec 05; Vol. 3 (6), pp. 824-843. Date of Electronic Publication: 2018 Dec 05 (Print Publication: 2018).