Zobrazeno 1 - 10
of 491
pro vyhledávání: '"CUL4A"'
Publikováno v:
Journal of Medical Biochemistry, Vol 41, Iss 1, Pp 62-70 (2022)
Background: Acute kidney injury (AKI) is a common disease that can develop into end-stage kidney disease. Sepsis is one of the main causes of AKI. Currently, there is no satisfactory way to treat septic AKI. Therefore, we have shown the protective fu
Externí odkaz:
https://doaj.org/article/6ca1635042104a4689e52e08f5422651
Akademický článek
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Autor:
O. H. Minchenko, O. S. Hnatiuk, D. O. Tsymbal, Y. M. Viletska, S. V. Danilovskyi, O. V. Halkin, I. V. Kryvdiuk, O. V. Rudnytska
Publikováno v:
The Ukrainian Biochemical Journal, Vol 92, Iss 5, Pp 50-61 (2020)
It was shown previously that inhibition of ERN1 (endoplasmic reticulum to nucleus signaling 1) pathway, a central mediator of the unfolded protein response, leads to suppression of tumor growth through down-regulation of key pro-proliferative and up-
Externí odkaz:
https://doaj.org/article/5e0e682008e545d7ae2fe5d4263504ae
Publikováno v:
Cancer Biology & Medicine, Vol 17, Iss 2, Pp 357-370 (2020)
Objective: The E3 ligase, CRL4, plays diverse roles in different cellular processes, such as DNA damage, transcriptional regulation, cell cycle progression, and cell apoptosis. Our previous study showed that CUL4A and CUL4B had a strong association w
Externí odkaz:
https://doaj.org/article/98a5a54d3605449cb0e85b5b05b3ef83
Akademický článek
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Akademický článek
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Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-13 (2019)
Abstract Background Ubiquitin E3 ligase CUL4A plays important oncogenic roles in the development of cancers. DTL, one of the CUL4-DDB1 associated factors (DCAFs), may involve in the process of cancer development. Programmed cell death 4 (PDCD4) is a
Externí odkaz:
https://doaj.org/article/d22637fc8fbe4f2abad30143a9a35c48
Publikováno v:
Respiratory Research, Vol 20, Iss 1, Pp 1-14 (2019)
Abstract Background Chronic obstructive pulmonary disease (COPD) is a common respiratory disease with high morbidity and mortality. The most important pathophysiological change of COPD is airway obstruction. Airway obstruction can cause airflow restr
Externí odkaz:
https://doaj.org/article/fdd71c2b72e54022985a5e9faa2b048f
Autor:
Chao Li, Juyuan Bu, Yifeng Liao, Jin Zhang, Jun Han, Han Zhang, Hao Xing, Zhenli Li, Han Wu, Lei Liang, Mingda Wang, Wenxing Qin, Tian Yang
Publikováno v:
Cellular Physiology and Biochemistry, Vol 51, Iss 6, Pp 2829-2842 (2018)
Background/Aims: Cullin 4A (CUL4A) is vital in cell survival, development, growth and cell cycle, it plays an important role in chaperone-mediated ubiquitination and interacts with TP53 in carcinogenesis. However, the clinicopathologic significance o
Externí odkaz:
https://doaj.org/article/d2853b19a4344e16a070f37e8ade31d4
Autor:
Melanie J. Mittenbühler, Katarzyna Saedler, Hendrik Nolte, Lara Kern, Jun Zhou, Shu-Bing Qian, Lydia Meder, Roland T. Ullrich, Jens C. Brüning, F. Thomas Wunderlich
Publikováno v:
Molecular Metabolism, Vol 42, Iss , Pp 101085- (2020)
Objective: Single-nucleotide polymorphisms in the FTO gene encoding an m6Am and an m6A demethylase are associated with obesity. Moreover, recent studies have linked a dysregulation of m6A modifications and its machinery, including FTO, to the develop
Externí odkaz:
https://doaj.org/article/94aae171be7140c5bfb4613a037c4e19