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Autor:
Alice M. Banks, Colette J. Whitfield, Steven R. Brown, David A. Fulton, Sarah A. Goodchild, Christopher Grant, John Love, Dennis W. Lendrem, Jonathan E. Fieldsend, Thomas P. Howard
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss, Pp 218-229 (2022)
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal
Graphical abstract
Highlights • Novel cell-free protein synthesis reaction buffer improves performance by 400%. • Enhanced performance is maintained across the synthesis of different proteins. • Protein synthesis performance is robust acro
Highlights • Novel cell-free protein synthesis reaction buffer improves performance by 400%. • Enhanced performance is maintained across the synthesis of different proteins. • Protein synthesis performance is robust acro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75d8a1b131f6dc02f2654a6fd7aef7a7
http://www.sciencedirect.com/science/article/pii/S2001037021005213
http://www.sciencedirect.com/science/article/pii/S2001037021005213
Autor:
Caterina Strambio-De-Castillia, Stuart W. Peltz, Christopher R. Trotta, Joseph M. Colacino, Elizabeth Goodwin, Liangxian Cao, Yetao Wang, Ellen L Suder, Elke Mühlberger, Sina Bavari, Jason D. Graci, Allan Jacobson, Mark Pykett, Kylie O'Keefe, Rachel A. Sattler, Ronald Kong, Ellen Welch, Jeremy Luban, Katherine Cintron-Lue, Marla Weetall, Slobodan Paessler, Veronica Soloveva, Nikolai Naryshkin
Publikováno v:
Virus Research
bioRxiv
bioRxiv
Highlights • COVID-19 is typified by SARS-CoV-2 replication and excessive inflammatory response. • PTC299 is small orally available DHODH inhibitor that blocks pyrimidine synthesis. • PTC299 is potent inhibitor of the replication of SARS-CoV-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3cffc893d893918d7de424f44edd7c5
https://doi.org/10.1016/j.virusres.2020.198246
https://doi.org/10.1016/j.virusres.2020.198246
Publikováno v:
The Journal of Biological Chemistry
Psychrobacter cryohalolentis strain K5T is a Gram-negative organism first isolated in 2006. It has a complex O-antigen that contains, in addition to l-rhamnose and d-galactose, two diacetamido- and a triacetamido-sugar. The biochemical pathways for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb259a5276ce0c77259bfa77b82692d5
https://doi.org/10.1016/j.jbc.2021.100463
https://doi.org/10.1016/j.jbc.2021.100463
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 5, Iss 3, Pp 223-230 (2015)
Acta Pharmaceutica Sinica B, Vol 5, Iss 3, Pp 223-230 (2015)
Nucleotide pools in mammalian cells change due to the influence of antitumor drugs, which may help in evaluating the drug effect and understanding the mechanism of drug action. In this study, an ion-pair RP-HPLC method was used for a simple, sensitiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e4570a8b7fa77c93ff61bd2d9a519b1
https://pubmed.ncbi.nlm.nih.gov/26579450
https://pubmed.ncbi.nlm.nih.gov/26579450
Autor:
Banks AM; School of Natural and Environmental Sciences, Newcastle University, Newcastle upon Tyne NE1 7RU, United Kingdom., Whitfield CJ; School of Natural and Environmental Sciences, Newcastle University, Newcastle upon Tyne NE1 7RU, United Kingdom., Brown SR; Synthace Ltd., London W12 7FQ, United Kingdom., Fulton DA; School of Natural and Environmental Sciences, Newcastle University, Newcastle upon Tyne NE1 7RU, United Kingdom., Goodchild SA; Defence Science and Technology Laboratory, Porton Down, Salisbury SP4 0JQ, United Kingdom., Grant C; Synthace Ltd., London W12 7FQ, United Kingdom., Love J; Biosciences, University of Exeter, Exeter EX4 4QD, United Kingdom., Lendrem DW; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne NE1 7RU, United Kingdom., Fieldsend JE; Computer Science, University of Exeter, Exeter EX4 4QF, United Kingdom., Howard TP; School of Natural and Environmental Sciences, Newcastle University, Newcastle upon Tyne NE1 7RU, United Kingdom.
Publikováno v:
Computational and structural biotechnology journal [Comput Struct Biotechnol J] 2021 Dec 13; Vol. 20, pp. 218-229. Date of Electronic Publication: 2021 Dec 13 (Print Publication: 2022).
Autor:
Wang F; School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China., Liu X; School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China., Liu C; School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China., Liu Z; School of Life Science and Bio-pharmaceutics Shenyang Pharmaceutical University, Shenyang 110016, China., Sun L; School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
Publikováno v:
Acta pharmaceutica Sinica. B [Acta Pharm Sin B] 2015 May; Vol. 5 (3), pp. 223-30. Date of Electronic Publication: 2015 Apr 08.