Zobrazeno 1 - 10
of 76
pro vyhledávání: '"CTGF, connective tissue growth factor"'
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2749-2767 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2749-2767 (2021)
Diabetic nephropathy (DN) has been recognized as a severe complication of diabetes mellitus and a dominant pathogeny of end-stage kidney disease, which causes serious health problems and great financial burden to human society worldwide. Conventional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d8ab4193adc39b242fa3c089b4f517
https://doi.org/10.1016/j.apsb.2020.12.020
https://doi.org/10.1016/j.apsb.2020.12.020
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 2, Pp 322-339 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Fibrosis is a pathological reparative process that can occur in most organs and is responsible for nearly half of deaths in the developed world. Despite considerable research, few therapies have proven effective and been approved clinically for treat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b31e277e49b3a3364e9726d531259ad4
https://doi.org/10.1016/j.apsb.2020.09.001
https://doi.org/10.1016/j.apsb.2020.09.001
Publikováno v:
Poultry Science, Vol 99, Iss 4, Pp 1832-1837 (2020)
Poultry Science
Poultry Science
Forty broilers maintained under natural hypobaric hypoxia (2,638 m above sea level) and 20 maintained under relative normoxia (460 m above sea level) were selected as pulmonary hypertensive (PHB) and nonpulmonary hypertensive (NPHB), to estimate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efd0e4b241695ba79dc56ae54dc1eda1
http://www.sciencedirect.com/science/article/pii/S0032579120301553
http://www.sciencedirect.com/science/article/pii/S0032579120301553
Publikováno v:
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 18, Iss, Pp 686-695 (2020)
Computational and Structural Biotechnology Journal, Vol 18, Iss, Pp 686-695 (2020)
Graphical abstract
Hepatocellular carcinoma (HCC) is an essentially incurable inflammation-related cancer. We have previously shown by network analysis of proteomic data that the flavonoids epigallocatechin gallate (EGCG) and fisetin (FIS) effic
Hepatocellular carcinoma (HCC) is an essentially incurable inflammation-related cancer. We have previously shown by network analysis of proteomic data that the flavonoids epigallocatechin gallate (EGCG) and fisetin (FIS) effic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc2b7c496c6b1b9ca88af07fd67f672e
https://doi.org/10.1016/j.csbj.2020.03.006
https://doi.org/10.1016/j.csbj.2020.03.006
Publikováno v:
Translational Oncology, Vol 14, Iss 12, Pp 101231-(2021)
Translational Oncology
Translational Oncology
Highlights • EVs mediate the interaction between tumor and stromal cells in the TME. • Tumors mediate CAF-like activation of stromal cells through EVs. • CAF-derived EVs promote tumor proliferation, metastasis and therapeutic resistance.
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Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc5dbb220f9849b850d3378d75eced1b
http://www.sciencedirect.com/science/article/pii/S1936523321002230
http://www.sciencedirect.com/science/article/pii/S1936523321002230
Autor:
Zoltan Szabo, Erhe Gao, Raisa Yrjölä, Laura Vainio, Ruizhu Lin, Risto Kerkelä, Walter J. Koch, Jarkko Piuhola, Kenneth E. Lipson, Heikki Ruskoaho, Johanna Magga, Johanna Ulvila, Shaun D. Fouse, Tarja Alakoski, Todd W. Seeley, Pierre E. Signore
Publikováno v:
JACC: Basic to Translational Science
JACC: Basic to Translational Science, Vol 4, Iss 1, Pp 83-94 (2019)
JACC: Basic to Translational Science, Vol 4, Iss 1, Pp 83-94 (2019)
Visual Abstract
Highlights • To study the role of CTGF in post-MI cardiac repair and LV remodeling, we antagonized the function of CTGF with a mAb. • Treatment of mice with CTGF mAb during post-MI cardiac repair improved survival and resulte
Highlights • To study the role of CTGF in post-MI cardiac repair and LV remodeling, we antagonized the function of CTGF with a mAb. • Treatment of mice with CTGF mAb during post-MI cardiac repair improved survival and resulte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0296a94ecc33dc48e5b4f09ec728306a
http://europepmc.org/articles/PMC6390503
http://europepmc.org/articles/PMC6390503
Autor:
Angela Mathison, Usman Yaqoob, Juan Pablo Arab, Vikas K. Verma, Vijay H. Shah, Philippe Mathurin, Gwen Lomberk, Sheng Cao, Rosa Martin-Mateos, Robert C. Huebert, Raul Urrutia, Thomas Greuter, Thiago M. De Assuncao, Nidhi Jalan-Sakrikar
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 1, Pp 197-209 (2019)
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 1, Pp 197-209 (2019)
Background & Aims Transdifferentiation of hepatic stellate cells (HSCs) into myofibroblasts is a key event in the pathogenesis of liver fibrosis. Transforming growth factor β (TGF-β) and platelet-derived growth factor (PDGF) are canonical HSC activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a05485b74c8dd1867da61269d6422e92
https://doi.org/10.1016/j.jcmgh.2018.09.005
https://doi.org/10.1016/j.jcmgh.2018.09.005
Autor:
Bernard L. Flynn, Ruth R Magaye, Xin Xiong, Peter J Meikle, Danny Liew, Feby Savira, Kevin Huynh, David M. Kaye, Bing Hui Wang, Christopher M. Reid
Publikováno v:
International Journal of Cardiology. Heart & Vasculature
International Journal of Cardiology: Heart & Vasculature, Vol 35, Iss, Pp 100837-(2021)
International Journal of Cardiology: Heart & Vasculature, Vol 35, Iss, Pp 100837-(2021)
Graphical abstract
Highlights • Increasing sphingolipid metabolism in cardiac fibroblasts inhibited TGFβ mediated collagen synthesis. • Dihydrosphingosine inhibits collagen synthesis in cardiac fibroblasts through substrate-enzyme-receptor
Highlights • Increasing sphingolipid metabolism in cardiac fibroblasts inhibited TGFβ mediated collagen synthesis. • Dihydrosphingosine inhibits collagen synthesis in cardiac fibroblasts through substrate-enzyme-receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7107d8c58bf953de354bb354b3a6ef20
https://pubmed.ncbi.nlm.nih.gov/34277924
https://pubmed.ncbi.nlm.nih.gov/34277924
Autor:
Xiaojuan, Zhang, Chuanchuan, He, Yun, Sun, Xiaoguang, Liu, Yan, Chen, Chen, Chen, Ruicong, Yan, Ting, Fan, Tan, Yang, Yao, Lu, Jun, Luo, Xiang, Ma, Guangya, Xiang
Publikováno v:
Acta Pharmaceutica Sinica. B
Drug transportation is impeded by various barriers in the hypoxic solid tumor, resulting in compromised anticancer efficacy. Herein, a solid lipid monostearin (MS)-coated CaO2/MnO2 nanocarrier was designed to optimize doxorubicin (DOX) transportation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::460386643ca1b16bac3281f4e9c23847
https://pubmed.ncbi.nlm.nih.gov/34900540
https://pubmed.ncbi.nlm.nih.gov/34900540
Autor:
Yue, Gao, Shicheng, Fan, Hua, Li, Yiming, Jiang, Xinpeng, Yao, Shuguang, Zhu, Xiao, Yang, Ruimin, Wang, Jianing, Tian, Frank J, Gonzalez, Min, Huang, Huichang, Bi
Publikováno v:
Acta Pharmaceutica Sinica. B
The constitutive androstane receptor (CAR, NR3I1) belongs to nuclear receptor superfamily. It was reported that CAR agonist TCPOBOP induces hepatomegaly but the underlying mechanism remains largely unknown. Yes-associated protein (YAP) is a potent re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d681e8ed3dec02a3fd494640b40d0aea
https://pubmed.ncbi.nlm.nih.gov/33777678
https://pubmed.ncbi.nlm.nih.gov/33777678