Blockade of TGF-β signaling reactivates HIV-1/SIV reservoirs and immune responsesin vivo

Autor: S Samer, Y Thomas, M Araínga, CM Carter, LM Shirreff, MS Arif, JM Avita, I Frank, M McRaven, CT Thuruthiyil, V Heybeli, MR Anderson, B Owen, A Gaisin, D Bose, LM Simons, JF Hultquist, J Arthos, C Cicala, I Sereti, P Santangelo, R Lorenzo-Redondo, TJ Hope, FJ Villinger, E Martinelli

Elevated levels of TGF-β, a potent immunosuppressive factor, are present in HIV-1 infected individuals even after years of antiretroviral therapy (ART). TGF-β plays a critical role in maintaining immune cells in a resting state by inhibiting cell a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7aa0d98ec5172e91c72a1850971fddbe
https://doi.org/10.1101/2022.05.13.489595

Blockade of TGF-β signaling reactivates HIV-1/SIV reservoirs and immune responses in vivo.

Autor: Samer S; Department of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Thomas Y; Department of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Araínga M; New Iberia Research Center (NIRC), University of Louisiana at Lafayette, New Iberia, Louisiana, USA., Carter C; New Iberia Research Center (NIRC), University of Louisiana at Lafayette, New Iberia, Louisiana, USA., Shirreff LM; New Iberia Research Center (NIRC), University of Louisiana at Lafayette, New Iberia, Louisiana, USA., Arif MS; Department of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Avita JM; Department of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Frank I; Center for Biomedical Research, Population Council, New York, New York, USA., McRaven MD; Department of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Thuruthiyil CT; Department of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Heybeli VB; Department of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Anderson MR; Department of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Owen B; Integrated Molecular Structure Education and Research (IMSERC), Northwestern University, Evanston, Illinois, USA., Gaisin A; Integrated Molecular Structure Education and Research (IMSERC), Northwestern University, Evanston, Illinois, USA., Bose D; New Iberia Research Center (NIRC), University of Louisiana at Lafayette, New Iberia, Louisiana, USA., Simons LM; Department of Medicine, Division of Infectious Diseases, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.; Center for Pathogen Genomics and Microbial Evolution, Havey Institute for Global Health Northwestern University, Chicago, Illinois, USA., Hultquist JF; Department of Medicine, Division of Infectious Diseases, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.; Center for Pathogen Genomics and Microbial Evolution, Havey Institute for Global Health Northwestern University, Chicago, Illinois, USA., Arthos J; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, USA., Cicala C; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, USA., Sereti I; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, USA., Santangelo PJ; WH Coulter Department of Biomedical Engineering, Emory University School of Medicine, Atlanta, Georgia, USA., Lorenzo-Redondo R; Department of Medicine, Division of Infectious Diseases, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.; Center for Pathogen Genomics and Microbial Evolution, Havey Institute for Global Health Northwestern University, Chicago, Illinois, USA., Hope TJ; Department of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Villinger FJ; New Iberia Research Center (NIRC), University of Louisiana at Lafayette, New Iberia, Louisiana, USA., Martinelli E; Department of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.

Publikováno v: JCI insight [JCI Insight] 2022 Nov 08; Vol. 7 (21). Date of Electronic Publication: 2022 Nov 08.