Zobrazeno 1 - 10
of 403
pro vyhledávání: '"CT Esmon"'
Autor:
M Delvaeye, M Noris, A De Vriese, CT Esmon, NL Esmon, G Ferrell, J Del-Favero, S Plaisance, B Claes, D Lambrechts, G Remuzzi, EM Conway
Publikováno v:
Clinical Journal of the American Society of Nephrology. 4:1701-1704
Publikováno v:
Blood. 83:2526-2531
Protein C is a vitamin K-dependent plasma serine protease zymogen, which upon activation, functions as an anticoagulant. Protein C activation is catalyzed by a complex of thrombin (T) with thrombomodulin (TM). This activation is Ca(2+)-dependent, but
Publikováno v:
Europe PubMed Central
Factor V (FV) present in platelet alpha-granules has a significant but incompletely understood role in hemostasis. This report demonstrates that a fraction of platelets express very high levels of surface-bound, alpha-granule FV on simultaneous activ
Publikováno v:
Europe PubMed Central
When amino acids Pro60B, Pro60C, and Trp60D are deleted from thrombin, the resulting mutant (des-PPW) exhibits (compared to the wild-type enzyme): a similar second order rate constant of inhibition (k(on)) for diisopropyl fluorophosphate, and a compa
Autor:
R Cullen, CT Esmon, Kenneth A. West, Brent Johnston, Steven F. Morris, Robert S. Liwski, Michael Bezuhly
Publikováno v:
Plastic and Reconstructive Surgery. 125:97
Publikováno v:
Blood. 67:504-508
Protein S is a natural anticoagulant present in the plasma that serves as a cofactor for activated protein C. Patients deficient in protein S are subject to recurrent venous thrombotic disease. Protein S deficiency differs from other plasma protein d
Publikováno v:
Blood. 63(1)
Protein C is a vitamin K-dependent plasma protein. Activated protein C is a potent anticoagulant and enhances blood clot lysis. We have developed a functional assay for protein C in human plasma. The measurement of protein C is accomplished by the ad
Publikováno v:
Blood. 73(1)
Tumor necrosis factor (TNF), a mediator of the inflammatory response, induces tissue factor and decreases the expression of thrombomodulin (TM) on endothelial cells, thus shifting the hemostatic properties of the endothelium. To determine the mechani
Autor:
Biguzzi E, Giampiero Merati, Pc, Liaw, Bucciarelli P, Oganesyan N, Qu D, Jm, Gu, Fetiveau R, Ct, Esmon, Pm, Mannucci, Em, Faioni
Publikováno v:
Europe PubMed Central
EPCR is a type I transmembrane protein, highly expressed on the endothelium of large vessels, that binds protein C and augments its activation. In this study, a 23bp insertion in the EPCR gene was found in 4/198 survivors of myocardial infarction and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8c514b7a4691d35b787ee6df88b2ca65
http://europepmc.org/abstract/med/11686350
http://europepmc.org/abstract/med/11686350
Publikováno v:
Europe PubMed Central
Despite considerable sequence similarities, blood coagulation serine proteases exhibit remarkable specificity with respect to which zymogen they activate. The basis for this specificity presumably involves recognition of a short sequence within the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d499ead0d730cc6d10d891e2db2c8a28
http://europepmc.org/abstract/med/1551906
http://europepmc.org/abstract/med/1551906