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Akademický článek

Getting to grips with circular chromosomes

Autor: Constance Nugent, Katsunori Sugimoto

Publikováno v: eLife, Vol 9 (2020)

A strain of budding yeast that contains one large chromosome reveals how the telomere capping complex CST maintains linear but not circular chromosomes.

Externí odkaz: https://doaj.org/article/e63da8e66c824d8ca6523222f35969e1

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Akademický článek

Cdc13 is predominant over Stn1 and Ten1 in preventing chromosome end fusions

Autor: Zhi-Jing Wu, Jia-Cheng Liu, Xin Man, Xin Gu, Ting-Yi Li, Chen Cai, Ming-Hong He, Yangyang Shao, Ning Lu, Xiaoli Xue, Zhongjun Qin, Jin-Qiu Zhou

Publikováno v: eLife, Vol 9 (2020)

Telomeres define the natural ends of eukaryotic chromosomes and are crucial for chromosomal stability. The budding yeast Cdc13, Stn1 and Ten1 proteins form a heterotrimeric complex, and the inactivation of any of its subunits leads to a uniformly let

Externí odkaz: https://doaj.org/article/d1d0382480b540a39cf37dfecaca48d3

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Akademický článek

Structural Analysis and Conformational Dynamics of STN1 Gene Mutations Involved in Coat Plus Syndrome

Autor: Mohd. Amir, Taj Mohammad, Vijay Kumar, Mohammed F. Alajmi, Md. Tabish Rehman, Afzal Hussain, Perwez Alam, Ravins Dohare, Asimul Islam, Faizan Ahmad, Md. Imtaiyaz Hassan

Publikováno v: Frontiers in Molecular Biosciences, Vol 6 (2019)

The human CST complex (CTC1–STN1–TEN1) is associated with telomere functions including genome stability. We have systemically analyzed the sequence of STN and performed structure analysis to establish its association with the Coat Plus (CP) syndr

Externí odkaz: https://doaj.org/article/6df649d626844a6b929394adb2889009

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Akademický článek

Structural Features of Nucleoprotein CST/Shelterin Complex Involved in the Telomere Maintenance and Its Association with Disease Mutations

Autor: Mohd. Amir, Parvez Khan, Aarfa Queen, Ravins Dohare, Mohamed F. Alajmi, Afzal Hussain, Asimul Islam, Faizan Ahmad, Md. Imtaiyaz Hassan

Publikováno v: Cells, Vol 9, Iss 2, p 359 (2020)

Telomere comprises the ends of eukaryotic linear chromosomes and is composed of G-rich (TTAGGG) tandem repeats which play an important role in maintaining genome stability, premature aging and onsets of many diseases. Majority of the telomere are rep

Externí odkaz: https://doaj.org/article/7e2813bed12341af886db3b6890bf518

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The evolution of metazoan shelterin

Autor: Logan R. Myler, Charles G Kinzig, Titia de Lange, George Zakusilo, Sarah W Cai, Nanda Kumar Sasi

Publikováno v: Genes Dev

The mammalian telomeric shelterin complex—comprised of TRF1, TRF2, Rap1, TIN2, TPP1, and POT1—blocks the DNA damage response at chromosome ends and interacts with telomerase and the CST complex to regulate telomere length. The evolutionary origin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::589d68f7eec39a102cf4f7dcaef4960b
https://doi.org/10.1101/gad.348835.121

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Akademický článek

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The fission yeast Stn1-Ten1 complex limits telomerase activity via its SUMO-interacting motif and promotes telomeres replication

Autor: Matmati, Samah, Vaurs, Mélina, Escandell, José M., Maestroni, Laetitia, Nakamura, Toru M., Ferreira, Miguel G., Géli, Vincent, Coulon, Stéphane

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Science Advances
Science Advances, Vol. 4, no.5, p. 1-14 (2018)
Science Advances, 2018, 4 (5), pp.eaar2740. ⟨10.1126/SCIADV.AAR2740⟩
Science Advances, American Association for the Advancement of Science (AAAS), 2018, 4 (5), pp.eaar2740. ⟨10.1126/SCIADV.AAR2740⟩
Science Advances, American Association for the Advancement of Science (AAAS), 2018, 4 (5), ⟨10.1126/sciadv.aar2740⟩

The Stn1-Ten1 complex has a dual function at telomeres.
Mammalian CST (CTC1-STN1-TEN1) complex fulfills numerous functions including rescue of the stalled replication forks and termination of telomerase action. In fission yeast lacking the CTC1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8607ea190ea2888446c3f10c3c364695

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[Untitled]

Autor: Jonkers, J.M.M., Rottenberg, S., Irth, H., Bouwstra, J.A., Attikum, H. van, Noordermeer, S.M., Vugt, M. van, Leiden University

The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______202::2866891b9b6875b365358b3797c884f3

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