Zobrazeno 1 - 10
of 435
pro vyhledávání: '"CSPG4"'
Autor:
Lidia Giraudo, Giulia Cattaneo, Loretta Gammaitoni, Ilenia Iaia, Chiara Donini, Annamaria Massa, Maria Laura Centomo, Marco Basiricò, Elisa Vigna, Alberto Pisacane, Franco Picciotto, Enrico Berrino, Caterina Marchiò, Alessandra Merlini, Luca Paruzzo, Stefano Poletto, Daniela Caravelli, Andrea Michela Biolato, Valentina Bortolot, Elisa Landoni, Marco Ventin, Cristina R. Ferrone, Massimo Aglietta, Gianpietro Dotti, Valeria Leuci, Fabrizio Carnevale-Schianca, Dario Sangiolo
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-13 (2023)
Abstract Background Even acknowledging the game-changing results achieved in the treatment of metastatic melanoma with the use of immune checkpoint inhibitors (ICI), a large proportion of patients (40–60%) still fail to respond or relapse due to th
Externí odkaz:
https://doaj.org/article/3eb42d63a9594f5d95b1ee9f44199df2
Autor:
Alex S. Woodell, Elisa Landoni, Alain Valdivia, Andrew Buckley, Edikan A. Ogunnaike, Gianpietro Dotti, Shawn D. Hingtgen
Publikováno v:
Bioengineering & Translational Medicine, Vol 8, Iss 6, Pp n/a-n/a (2023)
Abstract Chimeric antigen receptor (CAR)‐modified T‐cell therapy has shown enormous clinical promise against blood cancers, yet efficacy against solid tumors remains a challenge. Here, we investigated the potential of a new combination cell thera
Externí odkaz:
https://doaj.org/article/2703b17aad854d00917108d980cb7bf5
Autor:
Korbinian N. Kropp, Martina Fatho, Enes Huduti, Marilena Faust, Silke Lübcke, Volker Lennerz, Annette Paschen, Matthias Theobald, Thomas Wölfel, Catherine Wölfel
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntorductionChondroitin sulfate proteoglycan 4 (CSPG4), also known as high molecular weight-melanoma associated antigen, is expressed in melanoma but also other tumor entities and constitutes an attractive target for immunotherapeutic approaches. Whi
Externí odkaz:
https://doaj.org/article/876d109a9f104f8e9183472e9034a50a
Autor:
Laurys Boudin, A de Nonneville, Pascal Finetti, Léna Mescam, A Le Cesne, Antoine Italiano, Jean-Yves Blay, Daniel Birnbaum, Emilie Mamessier, François Bertucci
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-13 (2022)
Abstract Background Soft tissue sarcomas (STS) are heterogeneous and pro-metastatic tumors. Identification of accurate prognostic factors and novel therapeutic targets are crucial. CSPG4 is a cell surface proteoglycan with oncogenic functions. It rec
Externí odkaz:
https://doaj.org/article/f6527691660149788a4e90bf8c5daef5
Autor:
Sjoerd P. F. T. Nota, David O. Osei-Hwedieh, David L. Drum, Xinhui Wang, Francesco Sabbatino, Soldano Ferrone, Joseph H. Schwab
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Chondrosarcoma is a common primary bone malignancy whose phenotype increases with its histologic grade. They are relatively resistant to chemotherapy and radiation therapy limiting curative options for disseminated disease. Chondroitin sulfate proteo
Externí odkaz:
https://doaj.org/article/6dec049dbcc848f4bc918df303ea9467
Autor:
Lidia Tarone, Davide Giacobino, Mariateresa Camerino, Soldano Ferrone, Paolo Buracco, Federica Cavallo, Federica Riccardo
Publikováno v:
Frontiers in Veterinary Science, Vol 9 (2022)
In veterinary oncology, canine melanoma is still a fatal disease for which innovative and long-lasting curative treatments are urgently required. Considering the similarities between canine and human melanoma and the clinical revolution that immunoth
Externí odkaz:
https://doaj.org/article/c32755179ef34ef292c46e70b42becab
Autor:
Lidia Tarone, Katia Mareschi, Elisa Tirtei, Davide Giacobino, Mariateresa Camerino, Paolo Buracco, Emanuela Morello, Federica Cavallo, Federica Riccardo
Publikováno v:
Life, Vol 12, Iss 12, p 2099 (2022)
Osteosarcoma (OSA) is the most common pediatric malignant bone tumor. Although surgery together with neoadjuvant/adjuvant chemotherapy has improved survival for localized OSA, most patients develop recurrent/metastatic disease with a dismally poor ou
Externí odkaz:
https://doaj.org/article/91546c5b0c564a23a0a19eff4d83ad34
Publikováno v:
Biomedicines, Vol 10, Iss 9, p 2158 (2022)
Melanoma is highly aggressive and is known to be efficient at resisting drug-induced apoptotic signals. Resection is currently the gold standard for melanoma management, but it only offers local control of the early stage of the disease. Metastatic m
Externí odkaz:
https://doaj.org/article/d26ecdbcb05049fd9bdaf5dd2db2e84f
Autor:
Yang Liu, Grace Hammel, Minjun Shi, Zhijian Cheng, Sandra Zivkovic, Xiaoqi Wang, Pingyi Xu, Xijing He, Bing Guo, Yi Ren, Li Zuo
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Although the increased expression of members of the chondroitin sulfate proteoglycan family, such as neuron-glial antigen 2 (NG2), have been well documented after an injury to the spinal cord, a complete picture as to the cellular origins and functio
Externí odkaz:
https://doaj.org/article/a04366b76a2e4f9ca5ac4fc10f46ee54
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