Zobrazeno 1 - 10
of 68
pro vyhledávání: '"CSC, Cancer stem cell"'
Autor:
Pu Xia, Anna Dubrovska
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
The SLC3A2 gene encodes for a cell-surface transmembrane protein CD98hc (4F2). CD98hc serves as a chaperone for LAT1 (SLC7A5), LAT2 (SLC7A8), y+LAT1 (SLC7A7), y+LAT2 (SLC7A6), xCT (SLC7A11) and Asc1 (SLC7A10) providing their recruitment to the plasma
Externí odkaz:
https://doaj.org/article/843b45ff6bcd4388894acbffe12315f2
Autor:
Goshi Shiota, Hiroyuki Tsuchiya
Publikováno v:
Tsuchiya, Hiroyuki. Shiota, Goshi. Immune evasion by cancer stem cells. Regenerative Therapy. 17. 20-33. doi:10.1016/j.reth.2021.02.006
Regenerative Therapy, Vol 17, Iss, Pp 20-33 (2021)
Regenerative Therapy
Regenerative Therapy, Vol 17, Iss, Pp 20-33 (2021)
Regenerative Therapy
Tumor immunity represents a new avenue for cancer therapy. Immune checkpoint inhibitors have successfully improved outcomes in several tumor types. In addition, currently, immune cell-based therapy is also attracting significant attention. However, t
Autor:
Umesh R. Desai, Anh T. Le, Howard Li, Leslie L. Muldoon, Chetna Sharon, Bhaumik B. Patel, Srinivas Sistla, Nehru Viji Sankaranarayanan, Y. Jeffrey Wu, Pavani Pingali, Alexander J. Neuwelt, Rio S. Boothello, Robert C. Doebele
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 3, Pp 348-359 (2021)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
High-dose acetaminophen (AAP) with delayed rescue using n-acetylcysteine (NAC), the FDA-approved antidote to AAP overdose, has demonstrated promising antitumor efficacy in early phase clinical trials. However, the mechanism of action (MOA) of AAP's a
Autor:
Riris Istighfari Jenie, Adam Hermawan, Haruma Anggraini Muflikhasari, Sonia Meta Angraini, Ika Putri Nurhayati, Muthi Ikawati, Herwandhani Putri, Annisa Khumaira
Publikováno v:
Saudi Pharmaceutical Journal, Vol 29, Iss 1, Pp 12-26 (2021)
Saudi Pharmaceutical Journal : SPJ
Saudi Pharmaceutical Journal : SPJ
Cancer therapy is a strategic measure in inhibiting breast cancer stem cell (BCSC) pathways. Naringenin, a citrus flavonoid, was found to increase breast cancer cells’ sensitivity to chemotherapeutic agents. Bioinformatics study and 3D tumorsphere
Autor:
Zhouhong Ge, Ron Smits, Lucia Campos Carrascosa, Dave Sprengers, Jaap Kwekkeboom, Jan N. M. IJzermans, Guoying Zhou, Maikel P. Peppelenbosch, Ruby Lieshout, Ling Wang, Wanlu Cao, Lisanne Noordam, Pengfei Li, Qin Yang, Junhong Su, Jiaye Liu, Luc J. W. van der Laan, Meng Li, Buyun Ma, Monique M A Verstegen, Qiuwei Pan, Ruyi Zhang
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, 11(2), 407-431. Elsevier Inc.
Cellular and Molecular Gastroenterology and Hepatology, 11(2), 407-431. Elsevier Inc.
Background & Aims Cancer-associated fibroblasts (CAFs) play a key role in the cancer process, but the research progress is hampered by the paucity of preclinical models that are essential for mechanistic dissection of cancer cell–CAF interactions.
Autor:
Jing Liang, Haiyan Liang, Zhongjun Dong, Weidong Zhao, Ying Zhou, Keqin Yan, Dingqing Feng, Bin Ling, Huan Yu, Wenhui Wang
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 1, Pp 1-11 (2021)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
Our previous work demonstrated that Piwil2 reactivated by the human papillomavirus oncoproteins E6 and E7 may reprogram somatic cells into tumor-initiating cells (TICs), which contribute to cervical neoplasia lesions. Maintaining the stemness of TICs
Autor:
Marie D. Ralff, Benedito A. Carneiro, Lanlan Zhou, Wen-I Chang, Rohinton Tarapore, Varun V. Prabhu, Joshua N. Honeyman, Attila A. Seyhan, Isacco Ferrarini, Alexander G. Raufi, Lindsey Carlsen, Martin Stogniew, Lee Schalop, Robyn Borsuk, Joshua E. Allen, Aakash Jhaveri, Cassandra Parker, Sara Morrow, Young Lee, Fabio Tavora, Wolfgang Oster, Jocelyn E. Ray, Kelsey E. Huntington, Howard Safran, Anna D Louie, Abed Rahman Kawakibi, Yiqun Zhang, Wafik S. El-Deiry
Publikováno v:
Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 12, Pp 725-744 (2020)
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 12, Pp 725-744 (2020)
ONC201 was originally discovered as TNF-Related Apoptosis Inducing Ligand (TRAIL)-inducing compound TIC10. ONC201 appears to act as a selective antagonist of the G protein coupled receptor (GPCR) dopamine receptor D2 (DRD2), and as an allosteric agon
Autor:
Feng Li, Yuqiao Sheng, Kangdong Liu, Yu Ping, Shumin Wang, Yi Zhang, Jingyao Lian, Yujing Xuan, Kai Zhang, Xiaojuan Shi, Zhen Zhang, Daiqun Zhang
Publikováno v:
Translational Oncology, Vol 14, Iss 8, Pp 101138-(2021)
Translational Oncology
Translational Oncology
Highlights • CD276 is homogeneously overexpressed in ESCC and EAC. • CD276-directed CAR-T cells demonstrate remarkable anti-tumor effects in ESCC PDX model. • CD276-targeting CAR-T cells are successfully generated with patients T cells and show
Autor:
Yangchao Chen, Tian Xia, Guolin Li, Frederic Khe Cheong Fung, Ka Fai To, Joanna H.M. Tong, Chi Han Li, Yin-Xin Zhu, Chi Hin Wong, Huiyi Feng, Rufu Chen
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 4, Pp 811-828 (2020)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Gemcitabine resistance is rapidly acquired by pancreatic ductal adenocarcinoma (PDAC) patients. Novel approaches that predict the gemcitabine response of patients and enhance gemcitabine chemosensitivity are important to improve pat
Autor:
Hideyuki Saya, Go J. Yoshida
Publikováno v:
Regenerative Therapy
Regenerative Therapy, Vol 17, Iss, Pp 38-50 (2021)
Regenerative Therapy, Vol 17, Iss, Pp 38-50 (2021)
Intratumoral heterogeneity is tightly associated with the failure of anticancer treatment modalities including conventional chemotherapy, radiation therapy, and molecularly targeted therapy. Such heterogeneity is generated in an evolutionary manner n