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The fungal ligand chitin directly binds and signals inflammation dependent on oligomer size and TLR2
Autor:
Boris Macek, Katharina Fuchs, Alexander N.R. Weber, Kirsten J. Koymans, Daniel L. Hartl, Salomé LeibundGut-Landmann, Zsofia Bittner, Tharmila Sanmuganantham, Anurag Singh, Franziska Herster, Andrea A. Gust, Olaf-Oliver Wolz, Sabine Dickhöfer, Felix Frauhammer, Truong Minh Dang, Lloyd S. Miller, M Krach, Martin Frank, Nadine A. Schilling, Christoph Taumer, Yamel Cardona Gloria, CS Cruz Dela, Lokesh Sharma, Maria A. Schlöffel, Cécile Gouttefangeas, Carly A. Dillen, Thorsten Nürnberger, Daniel J. Haischer
Chitin is a highly abundant polysaccharide and linked to fungal infection and asthma. Unfortunately, its polymeric structure has hampered the identification of immune receptors directly binding chitin and signaling immune activation and inflammation,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::279a6066c03e0e9288468eaaf72f9bc5
https://doi.org/10.1101/270405
https://doi.org/10.1101/270405
