Zobrazeno 1 - 10
of 1 484
pro vyhledávání: '"CRM1"'
Autor:
Pragya Gehlot, Daniela Brünnert, Vibha Kaushik, Arpana Yadav, Saloni Bage, Kritika Gaur, Mahesh Saini, Jens Ehrhardt, Gowrang Kasaba Manjunath, Abhishek Kumar, Neena Kasliwal, Ajay Kumar Sharma, Marek Zygmunt, Pankaj Goyal
Publikováno v:
Biochemistry and Biophysics Reports, Vol 39, Iss , Pp 101793- (2024)
Plasminogen activator inhibitor-1 (PAI-1/Serpin E1) is classically known for its antifibrinolytic activity via inhibiting uPA and tPA of the fibrinolytic pathway. PAI-1 has a paradoxical role in tumor progression, and its molecular functions are poor
Externí odkaz:
https://doaj.org/article/cbe64e65a65e406c913b8cde44a24a62
Publikováno v:
Oncology Reviews, Vol 18 (2024)
Chromosome Region Maintenance 1 (CRM1), also known as Exportin 1 (XPO1), is a protein that is critical for transport of proteins and RNA to the cytoplasm through the nuclear pore complex. CRM1 inhibition with small molecule inhibitors is currently be
Externí odkaz:
https://doaj.org/article/e5bc8c6adb384b8b8cc22dcfd2c8e2cc
Autor:
He Liu, Meisuo Liu, Xibao Tian, Haina Wang, Jiujiao Gao, Hanrui Li, Zhehuan Zhao, Yu Liu, Caigang Liu, Xuan Chen, Yongliang Yang
Publikováno v:
eLife, Vol 12 (2023)
Background: The overactivation of NF-κB signaling is a key hallmark for the pathogenesis of extranodal natural killer/T cell lymphoma (ENKTL), a very aggressive subtype of non-Hodgkin’s lymphoma yet with rather limited control strategies. Previous
Externí odkaz:
https://doaj.org/article/cc948c2dee4b47448c7afef5dc1bc570
Publikováno v:
Frontiers in Virology, Vol 3 (2023)
IntroductionThe influenza virus genome consists of single-stranded RNAs and forms viral ribonucleoprotein (RNP) complexes. After viral genome replication in the nucleus, the viral RNP interacts with viral protein M1. The M1-viral RNP complex is expor
Externí odkaz:
https://doaj.org/article/e7a687dafaea4fbeb7706bc544e2ed7e
Publikováno v:
Clinical and Translational Discovery, Vol 3, Iss 3, Pp n/a-n/a (2023)
Externí odkaz:
https://doaj.org/article/13735357856741d5a24d3aecc570e273
Autor:
Jie Zhou, Zengjie Lei, Jianfang Chen, Shengbo Liao, Yanrong Chen, Chengxiang Liu, Shuo Huang, Liuli Li, Yan Zhang, Pei Wang, Yinghui Huang, Jianjun Li, Houjie Liang
Publikováno v:
Clinical and Translational Medicine, Vol 13, Iss 5, Pp n/a-n/a (2023)
Abstract Background During the tumourigenesis and development of colorectal cancer (CRC), the inactivation of tumour suppressor genes is closely involved, although detailed molecular mechanisms remain elusive. Accumulating studies, including ours, ha
Externí odkaz:
https://doaj.org/article/00556e9142d04deaaed07c5d2962aaf9
Akademický článek
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Publikováno v:
Journal of Biomedical Science, Vol 29, Iss 1, Pp 1-16 (2022)
Abstract Background Hepatitis B virus (HBV) is a major human pathogen worldwide. To date, there is no curative treatment for chronic hepatitis B. The mechanism of virion secretion remains to be investigated. Previously, we found that nuclear export o
Externí odkaz:
https://doaj.org/article/2d36e4a7b21d4504afc6b382465902c8
Akademický článek
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Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 16, p 12593 (2023)
Gene expression in eukaryotes begins with transcription in the nucleus, followed by the synthesis of messenger RNA (mRNA), which is then exported to the cytoplasm for its translation into proteins. Along with transcription and translation, mRNA expor
Externí odkaz:
https://doaj.org/article/5ce469db1e434bdfb6e5901330e07765