Zobrazeno 1 - 10
of 262
pro vyhledávání: '"CRISPR activation"'
Autor:
Cuimei Zhang, Yajun Tang, Shanjie Tang, Lei Chen, Tong Li, Haidi Yuan, Yujun Xu, Yangyan Zhou, Shuaibin Zhang, Jianli Wang, Hongyu Wen, Wenbo Jiang, Yongzhen Pang, Xian Deng, Xiaofeng Cao, Junhui Zhou, Xianwei Song, Qikun Liu
Publikováno v:
Plant Communications, Vol 5, Iss 5, Pp 100823- (2024)
The inducible CRISPR activation (CRISPR-a) system offers unparalleled precision and versatility for regulating endogenous genes, making it highly sought after in plant research. In this study, we developed a chemically inducible CRISPR-a tool for pla
Externí odkaz:
https://doaj.org/article/bdc67300aef849f3b0e241817409089b
Characterization of transcriptional enhancers in the chicken genome using CRISPR-mediated activation
Publikováno v:
Frontiers in Genome Editing, Vol 5 (2023)
DNA regulatory elements intricately control when, where, and how genes are activated. Therefore, understanding the function of these elements could unveil the complexity of the genetic regulation network. Genome-wide significant variants are predomin
Externí odkaz:
https://doaj.org/article/8e8890569db54568bda7c6a1d962b0f6
Autor:
Elena Moreno-Giménez, Mónica Gandía, Zara Sáez, Paloma Manzanares, Lynne Yenush, Diego Orzáez, Jose F. Marcos, Sandra Garrigues
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
Fungal synthetic biology is a rapidly expanding field that aims to optimize the biotechnological exploitation of fungi through the generation of standard, ready-to-use genetic elements, and universal syntax and rules for contributory use by the funga
Externí odkaz:
https://doaj.org/article/9779e0e3b0e043538b47783861e845ce
Publikováno v:
eLife, Vol 12 (2023)
Loss-of-function and gain-of-function genetic perturbations provide valuable insights into gene function. In Drosophila cells, while genome-wide loss-of-function screens have been extensively used to reveal mechanisms of a variety of biological proce
Externí odkaz:
https://doaj.org/article/81bc1238df93453cba5fd72e36c000f8
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
Aedes mosquitoes transmit several pathogens including flaviviruses to humans which result in high morbidity and mortality. Owing to adaptability and climate change, these mosquito vectors are predicted to establish in new geographical areas thus expo
Externí odkaz:
https://doaj.org/article/1beeeaf7da4140fe9748f0f152535ab5
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 19, p 14865 (2023)
CRISPR/Cas9-mediated cleavage of DNA, which depends on the endonuclease activity of Cas9, has been widely used for gene editing due to its excellent programmability and specificity. However, the changes to the DNA sequence that are mediated by CRISPR
Externí odkaz:
https://doaj.org/article/97bf9d7c7cc84734850369c055132347
Publikováno v:
Materials Today Bio, Vol 16, Iss , Pp 100356- (2022)
Healing of large calvarial bone defects remains challenge but may be improved by stimulating bone regeneration of implanted cells. The aim of this study is to specially co-activate transforming growth factor β1 (TGF-β1) and vascular endothelial gro
Externí odkaz:
https://doaj.org/article/6108a473bd0a43998040032a9086aae3
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