T50 - Longitudinal Epigenetic Analysis Of Clozapine Use In Treatment-Resistant Schizophrenia: Data From The Crestar Consortium

Autor: Gillespie, Amy, Hannon, Eilis, Dempster, Emma, Collier, David, Egerton, Alice, Mill, Jonathan, MacCabe, James

Publikováno v: In European Neuropsychopharmacology 2017 27 Supplement 3:S463-S464

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Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection

Autor: Pardiñas, Antonio F, Holmans, Peter, Pocklington, Andrew J, Escott-Price, Valentina, Ripke, Stephan, Carrera, Noa, Legge, Sophie E, Bishop, Sophie, Cameron, Darren, Hamshere, Marian L, Han, Jun, Hubbard, Leon, Lynham, Amy, Mantripragada, Kiran, Rees, Elliott, MacCabe, James H, McCarroll, Steven A, Baune, Bernhard T, Breen, Gerome, Byrne, Enda M, Dannlowski, Udo, Eley, Thalia C, Hayward, Caroline, Martin, Nicholas G, McIntosh, Andrew M, Plomin, Robert, Porteous, David J, Wray, Naomi R, Caballero, Armando, Geschwind, Daniel H, Huckins, Laura M, Ruderfer, Douglas M, Santiago, Enrique, Sklar, Pamela, Stahl, Eli A, Won, Hyejung, Agerbo, Esben, Als, Thomas D, Andreassen, Ole A, Bækvad-Hansen, Marie, Mortensen, Preben Bo, Pedersen, Carsten Bøcker, Børglum, Anders D, Bybjerg-Grauholm, Jonas, Djurovic, Srdjan, Durmishi, Naser, Pedersen, Marianne Giørtz, Golimbet, Vera, Grove, Jakob, Hougaard, David M, Mattheisen, Manuel, Molden, Espen, Mors, Ole, Nordentoft, Merete, Pejovic-Milovancevic, Milica, Sigurdsson, Engilbert, Silagadze, Teimuraz, Hansen, Christine Søholm, Stefansson, Kari, Stefansson, Hreinn, Steinberg, Stacy, Tosato, Sarah, Werge, Thomas, GERAD1 Consortium, CRESTAR Consortium, Collier, David A, Rujescu, Dan, Kirov, George, Owen, Michael J, O'Donovan, Michael C, Walters, James TR

Publikováno v: Nature genetics, vol 50, iss 3

Schizophrenia is a debilitating psychiatric condition often associated with poor quality of life and decreased life expectancy. Lack of progress in improving treatment outcomes has been attributed to limited knowledge of the underlying biology, altho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::e8c4b6ad09258d59dd64df9a5a561e98
https://escholarship.org/uc/item/5qp950vs

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Publisher Correction: Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection.

Autor: Pardiñas AF; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK., Holmans P; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK., Pocklington AJ; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK., Escott-Price V; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK., Ripke S; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Department of Psychiatry and Psychotherapy, Charité, Campus Mitte, Berlin, Germany., Carrera N; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK., Legge SE; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK., Bishop S; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK., Cameron D; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK., Hamshere ML; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK., Han J; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK., Hubbard L; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK., Lynham A; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK., Mantripragada K; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK., Rees E; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK., MacCabe JH; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., McCarroll SA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Baune BT; Discipline of Psychiatry, University of Adelaide, Adelaide, South Australia, Australia., Breen G; MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; NIHR Biomedical Research Centre for Mental Health, Maudsley Hospital and Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Byrne EM; Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., Dannlowski U; Department of Psychiatry and Psychotherapy, University of Münster, Münster, Germany., Eley TC; MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Hayward C; Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., Martin NG; School of Psychology, University of Queensland, Brisbane, Queensland, Australia.; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., McIntosh AM; Division of Psychiatry, University of Edinburgh, Edinburgh, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK., Plomin R; MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Porteous DJ; Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., Wray NR; Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., Caballero A; Departamento de Bioquímica, Genética e Inmunología. Facultad de Biología, Universidad de Vigo, Vigo, Spain., Geschwind DH; Department of Neurology, Center for Autism Research and Treatment, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Huckins LM; Division of Psychiatric Genomics, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Ruderfer DM; Division of Psychiatric Genomics, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Santiago E; Departamento de Biología Funcional. Facultad de Biología, Universidad de Oviedo, Oviedo, Spain., Sklar P; Division of Psychiatric Genomics, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Stahl EA; Division of Psychiatric Genomics, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Won H; Department of Neurology, Center for Autism Research and Treatment, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Agerbo E; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark., Als TD; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; iSEQ, Center for Integrative Sequencing, Aarhus University, Aarhus, Denmark.; Department of Biomedicine- Human Genetics, Aarhus University, Aarhus, Denmark., Andreassen OA; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway., Bækvad-Hansen M; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark., Mortensen PB; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark.; iSEQ, Center for Integrative Sequencing, Aarhus University, Aarhus, Denmark., Pedersen CB; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark., Børglum AD; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; iSEQ, Center for Integrative Sequencing, Aarhus University, Aarhus, Denmark.; Department of Biomedicine- Human Genetics, Aarhus University, Aarhus, Denmark., Bybjerg-Grauholm J; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark., Djurovic S; NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway.; Department of Medical Genetics, Oslo University Hospital, Oslo, Norway., Durmishi N; Department of Child and Adolescent Psychiatry, University Clinic of Psychiatry, Skopje, Macedonia., Pedersen MG; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark., Golimbet V; Department of Clinical Genetics, Mental Health Research Center, Moscow, Russia., Grove J; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; iSEQ, Center for Integrative Sequencing, Aarhus University, Aarhus, Denmark.; Department of Biomedicine- Human Genetics, Aarhus University, Aarhus, Denmark.; Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark., Hougaard DM; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark., Mattheisen M; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; iSEQ, Center for Integrative Sequencing, Aarhus University, Aarhus, Denmark.; Department of Biomedicine- Human Genetics, Aarhus University, Aarhus, Denmark., Molden E; Center for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway., Mors O; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Psychosis Research Unit, Aarhus University Hospital, Risskov, Denmark., Nordentoft M; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Mental Health Services in the Capital Region of Denmark, Mental Health Center Copenhagen, University of Copenhagen, Copenhagen, Denmark., Pejovic-Milovancevic M; Department of Psychiatry, School of Medicine, University of Belgrade, Belgrade, Serbia., Sigurdsson E; Department of Psychiatry, National University Hospital, Reykjavik, Iceland., Silagadze T; Department of Psychiatry and Drug Addiction, Tbilisi State Medical University (TSMU), Tbilisi, Georgia., Hansen CS; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark., Stefansson K; deCODE Genetics, Reykjavik, Iceland., Stefansson H; deCODE Genetics, Reykjavik, Iceland., Steinberg S; deCODE Genetics, Reykjavik, Iceland., Tosato S; Section of Psychiatry, Department of Public Health and Community Medicine, University of Verona, Verona, Italy., Werge T; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Institute of Biological Psychiatry, MHC Sct. Hans, Mental Health Services Copenhagen, Roskilde, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Collier DA; MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; Discovery Neuroscience Research, Eli Lilly and Company, Lilly Research Laboratories, Windlesham, UK., Rujescu D; Department of Psychiatry, University of Halle, Halle, Germany.; Department of Psychiatry, University of Munich, Munich, Germany., Kirov G; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK., Owen MJ; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK. owenmj@cardiff.ac.uk., O'Donovan MC; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK. odonovanmc@cardiff.ac.uk., Walters JTR; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK. waltersjt@cardiff.ac.uk.

Publikováno v: Nature genetics [Nat Genet] 2019 Jul; Vol. 51 (7), pp. 1193.