Fasting Hormones Synergistically Induce Amino Acid Catabolism Genes to Promote Gluconeogenesis

Autor: Maya Finkel, Nufar Buchshtab, Meirav Bar-Shimon, Noga Korenfeld, Ido Goldstein, Meital Charni-Natan

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 3, Pp 1021-1036 (2021)
Cellular and Molecular Gastroenterology and Hepatology

Background & Aims Gluconeogenesis from amino acids (AAs) maintains glucose homeostasis during fasting. Although glucagon is known to regulate AA catabolism, the contribution of other hormones to it and the scope of transcriptional regulation dictatin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ae2cd9101a9b091bf3a2c1fa8f4cfbf
https://doi.org/10.1016/j.jcmgh.2021.04.017

Hypoxia inhibits colonic uptake of the microbiota-generated forms of vitamin B1 via HIF-1α-mediated transcriptional regulation of their transporters

Autor: Sabui, Subrata, Ramamoorthy, Kalidas, Romero, Jose M, Simoes, Rita D, Fleckenstein, James M, Said, Hamid M

Publikováno v: The Journal of Biological Chemistry
The Journal of biological chemistry, vol 298, iss 2

Hypoxia exerts profound effects on cell physiology, but its effect on colonic uptake of the microbiota-generated forms of vitamin B1 (i.e., thiamin pyrophosphate [TPP] and free thiamine) has not been described. Here, we used human colonic epithelial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97ff343a85a7aede113b010d241e7a88
https://pubmed.ncbi.nlm.nih.gov/34998824

T cell–intrinsic prostaglandin E2-EP2/EP4 signaling is critical in pathogenic TH17 cell–driven inflammation

Autor: Lee, Jinju, Aoki, Tomohiro, Thumkeo, Dean, Siriwach, Ratklao, Yao, Chengcan, Narumiya, Shuh

Publikováno v: Lee, J, Aoki, T, Thumkeo, D, Siriwach, R, Yao, C & Narumiya, S 2019, ' T cell–intrinsic prostaglandin E 2-EP2/EP4 signaling is critical in pathogenic T H 17 cell–driven inflammation ', Journal of Allergy and Clinical Immunology, vol. 143, no. 2, pp. 631-643 . https://doi.org/10.1016/j.jaci.2018.05.036
The Journal of Allergy and Clinical Immunology

Background IL-23 is the key cytokine for generation of pathogenic IL-17–producing helper T (TH17) cells, which contribute critically to autoimmune diseases. However, how IL-23 generates pathogenic TH17 cells remains to be elucidated. Objectives We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::181c69c4df3bac11ac1ef93d317ae8f9
https://www.pure.ed.ac.uk/ws/files/64790710/PIIS0091674918308960.pdf

Macrophages: Their role, activation and polarization in pulmonary diseases

Autor: Beamon Agarwal, Kapil Dev, Mansoor Ali Syed, Shweta Arora, Pragnya Das

Publikováno v: Immunobiology

Macrophages, circulating in the blood or concatenated into different organs and tissues constitute the first barrier against any disease. They are foremost controllers of both innate and acquired immunity, healthy tissue homeostasis, vasculogenesis a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a71810ea31aed78f03302225fd75e687
https://pubmed.ncbi.nlm.nih.gov/29146235

Running on time: the role of circadian clocks in the musculoskeletal system

Autor: Michal, Dudek, Qing-Jun, Meng

Publikováno v: Biochemical Journal

The night and day cycle governs the circadian (24 hourly) rhythm of activity and rest in animals and humans. This is reflected in daily changes of the global gene expression pattern and metabolism, but also in the local physiology of various tissues.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4b039e200aef53b15c7ec94046eb070a
https://pubmed.ncbi.nlm.nih.gov/25195734