Zobrazeno 1 - 10
of 208
pro vyhledávání: '"CRAF"'
Autor:
Wei-Chia Hung, Cheinway Hwang, Shao-Hung Lin, Chuan-Sheng Wang, Yi-An Chen, Pei-Ching Tsai, Kuan-Chung Lin
Publikováno v:
Frontiers in Earth Science, Vol 12 (2024)
The Choushui River Alluvial Fan (CRAF) is a major agricultural area in Taiwan with heavy groundwater usage. The extraction of groundwater here has caused land subsidence, which is now a significant global environmental issue. This study analyzes land
Externí odkaz:
https://doaj.org/article/d7593dc1c034449c9e9cf0c069018057
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-34 (2023)
Abstract The RAS/mitogen-activated protein kinase (MAPK) signaling cascade is commonly dysregulated in human malignancies by processes driven by RAS or RAF oncogenes. Among the members of the RAF kinase family, CRAF plays an important role in the RAS
Externí odkaz:
https://doaj.org/article/d125e847832a4435a5db541aafe5edfc
Autor:
Hannah Rowlands, Kirsten Tschapalda, Carolyn Blackett, Delyan Ivanov, Darren Plant, Joseph Shaw, Andrew Thomas, Martin Packer, Laurence Arnold, Geoffrey A. Holdgate
Publikováno v:
SLAS Discovery, Vol 28, Iss 3, Pp 102-110 (2023)
The cellular thermal shift assay (CETSA®) has increasingly been used in early drug discovery to provide a measure of cellular target engagement. Traditionally, CETSA has been employed for bespoke questions with small to medium throughput and has pre
Externí odkaz:
https://doaj.org/article/ad58a2ad53e14749991c8324b2b3f6b8
Autor:
Shen Zhong, Jürgen Borlak
Publikováno v:
EBioMedicine, Vol 95, Iss , Pp 104763- (2023)
Summary: Background: Women are at greater risk of developing non-small cell lung cancer (NSCLC), yet the underlying causes remain unclear. Methods: We performed whole genome scans in lung tumours of cRaf transgenic mice and identified miRNA, transcri
Externí odkaz:
https://doaj.org/article/25513a74c75646a8b6457153dbd2b263
Akademický článek
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Autor:
Minghua Cao, Karol Nawalaniec, Amrendra K. Ajay, Yueming Luo, Romana Moench, Yanfei Jin, Sheng Xiao, Li-Li Hsiao, Ana Maria Waaga-Gasser
Publikováno v:
Translational Oncology, Vol 19, Iss , Pp 101377- (2022)
Clear cell renal cell carcinoma (ccRCC) is the most lethal form of kidney cancer and effective treatment regimens are yet to be established. Tyrosine kinase inhibitors (TKI) have widely been used as ccRCC therapeutics, but their efficacy is limited d
Externí odkaz:
https://doaj.org/article/5770d635e6b24c4bbdcaa37cd2d588f4
Autor:
Avinashnarayan Venkatanarayan, Jason Liang, Ivana Yen, Frances Shanahan, Benjamin Haley, Lilian Phu, Erik Verschueren, Trent B. Hinkle, David Kan, Ehud Segal, Jason E. Long, Tony Lima, Nicholas P.D. Liau, Jawahar Sudhamsu, Jason Li, Christiaan Klijn, Robert Piskol, Melissa R. Junttila, Andrey S. Shaw, Mark Merchant, Matthew T. Chang, Donald S. Kirkpatrick, Shiva Malek
Publikováno v:
Cell Reports, Vol 38, Iss 6, Pp 110351- (2022)
Summary: KRAS, which is mutated in ∼30% of all cancers, activates the RAF-MEK-ERK signaling cascade. CRAF is required for growth of KRAS mutant lung tumors, but the requirement for CRAF kinase activity is unknown. Here, we show that subsets of KRAS
Externí odkaz:
https://doaj.org/article/fa5d3d0fa6ab4799a1b8b428959ad8e4
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 1314-1320 (2019)
BRAF belongs to the upstream portion of the MAPK pathway, which is involved in cell proliferation and survival. When mutations occur in BRAF, downstream MEK and ERK are phosphorylated irrespective of RAS, resulting in melanoma-like cancer. Over the y
Externí odkaz:
https://doaj.org/article/07c5c571304347478ec389292c8ebde7
Akademický článek
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Akademický článek
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