Hallmarks of Aging in the Liver

Autor: David G. Le Couteur, Sun Woo Sophie Kang, Glen P Lockwood, Nicholas J. Hunt, Victoria C. Cogger

Publikováno v: Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 17, Iss, Pp 1151-1161 (2019)

While the liver demonstrates remarkable resilience during aging, there is growing evidence that it undergoes all the cellular hallmarks of aging, which increases the risk of liver and systemic disease. The aging process in the liver is driven by alte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbf961c6cce83782d5f12524960f4f45
https://doi.org/10.1016/j.csbj.2019.07.021

A cell-nonautonomous mechanism of yeast chronological aging regulated by caloric restriction and one-carbon metabolism

Autor: Elisa Enriquez-Hesles, Margaret B. Wierman, Ryan D. Fine, Sean M. Santos, Daniel L. Smith, Nazif Maqani, James R. Bain, Agata Kalita, Matthew D. Hirschey, Matthew D. Sutcliffe, Jeffrey S. Smith, John L. Hartman, Kevin A. Janes, Michael J. Muehlbauer

Publikováno v: The Journal of Biological Chemistry

Caloric restriction (CR) improves health span and life span of organisms ranging from yeast to mammals. Understanding the mechanisms involved will uncover future interventions for aging-associated diseases. In budding yeast, Saccharomyces cerevisiae,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86c7c1c9266dc964189fb3241f15bac4
https://pubmed.ncbi.nlm.nih.gov/33243834

Effect of DDT exposure on lipids and energy balance in obese Sprague-Dawley rats before and after weight loss

Autor: Peter J. Havel, Kimber L. Stanhope, Tomoko Ishikawa, James L. Graham, Michele A. La Merrill

Publikováno v: Ishikawa, Tomoko; Graham, James L; Stanhope, Kimber L; Havel, Peter J; & La Merrill, Michele A. (2015). Effect of DDT exposure on lipids and energy balance in obese Sprague-Dawley rats before and after weight loss.. Toxicology reports, 2, 990-995. doi: 10.1016/j.toxrep.2015.07.005. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/3bq9777t
Toxicology Reports
Toxicology Reports, Vol 2, Iss C, Pp 990-995 (2015)

Dichlorodiphenyltrichloroethane (DDT) and its metabolites accumulate in adipose tissue through dietary exposure, and have been proposed to contribute to the development of abdominal obesity, insulin resistance and dyslipidemia. Toxicity may also resu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b078c1846fbc86a7109f7d8c4dfebec
https://escholarship.org/uc/item/3bq9777t

Translatability of life‐extending pharmacological treatments between different species.

Autor: Burdusel, Daiana^1,2 (AUTHOR), Coman, Cristin³ (AUTHOR), Ancuta, Diana–Larisa³ (AUTHOR), Hermann, Dirk M.² (AUTHOR), Doeppner, Thorsten R.^4,5 (AUTHOR), Gresita, Andrei⁶ (AUTHOR), Popa‐Wagner, Aurel^1,2 (AUTHOR) aurel.popa‐wagner@geriatricshealthyageing.com

Publikováno v: Aging Cell. Jul2024, Vol. 23 Issue 7, p1-15. 15p.

Effect of long‐term caloric restriction on telomere length in healthy adults: CALERIE™ 2 trial analysis.

Autor: Hastings, Waylon J.¹ (AUTHOR), Ye, Qiaofeng² (AUTHOR), Wolf, Sarah E.^2,3 (AUTHOR), Ryan, Calen P.⁴ (AUTHOR), Das, Sai Krupa⁵ (AUTHOR), Huffman, Kim M.⁶ (AUTHOR), Kobor, Michael S.⁷ (AUTHOR), Kraus, William E.⁶ (AUTHOR), MacIsaac, Julia L.⁷ (AUTHOR), Martin, Corby K.⁸ (AUTHOR), Racette, Susan B.⁹ (AUTHOR), Redman, Leanne M.⁸ (AUTHOR), Belsky, Daniel W.^4,10 (AUTHOR), Shalev, Idan² (AUTHOR) ius14@psu.edu

Publikováno v: Aging Cell. Jun2024, Vol. 23 Issue 6, p1-11. 11p.