Tubeimoside-1 induces TFEB-dependent lysosomal degradation of PD-L1 and promotes antitumor immunity by targeting mTOR

Autor: Mingxiao Yin, Xiaojia Liu, Na Zhang, Genxiang Mao, Lu Liu, Hongbin Deng, Peng Yang, Wenjian Min, Kuang Ze'an, Jingwen Dong

Publikováno v: Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 3134-3149 (2021)
Acta Pharmaceutica Sinica. B

Programmed cell death ligand 1 (PD-L1)/programmed cell death protein 1 (PD-1) cascade is an effective therapeutic target for immune checkpoint blockade (ICB) therapy. Targeting PD-L1/PD-1 axis by small-molecule drug is an attractive approach to enhan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71d344df92d314f733377ab3c9584020
http://www.sciencedirect.com/science/article/pii/S2211383521001118

Monitoring Plasmodium vivax resistance to antimalarials: Persisting challenges and future directions

Autor: Simone Ladeia-Andrade, Rodrigo M. Corder, Marcelo U. Ferreira, Gabriel W. Rangel, Igor Cavallini Johansen, Taís Nóbrega de Sousa, José Pedro Gil

Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance, Vol 15, Iss, Pp 9-24 (2021)
International Journal for Parasitology: Drugs and Drug Resistance
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Emerging antimalarial drug resistance may undermine current efforts to control and eliminate Plasmodium vivax, the most geographically widespread yet neglected human malaria parasite. Endemic countries are expected to assess regularly the therapeutic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0e5ae265fa9864da475e8994bd43548
http://www.sciencedirect.com/science/article/pii/S221132072030049X

Recent advances in drug delivery systems for targeting cancer stem cells

Autor: Zhonggao Gao, Wei Huang, Hongxia Duan, Yanhong Liu

Publikováno v: Acta Pharmaceutica Sinica B, Vol 11, Iss 1, Pp 55-70 (2021)
Acta Pharmaceutica Sinica. B

Cancer stem cells (CSCs) are a subpopulation of cancer cells with functions similar to those of normal stem cells. Although few in number, they are capable of self-renewal, unlimited proliferation, and multi-directional differentiation potential. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daa624bee1b295d3b2a8ea11ea5504c8
http://www.sciencedirect.com/science/article/pii/S2211383520307322

COVID-19 infection and cardiac arrhythmias

Autor: Evdoxia J Apostolopoulos, Helen Melita, Antonis A. Manolis, Antonis S. Manolis, Theodora A Manolis, Despoina Papatheou

Publikováno v: Trends in Cardiovascular Medicine

Highlights • Serious cardiac arrhythmias may be the consequence of direct effects of COVID-19 infection, but also the outcome of the deleterious effects of systemic illness and the adverse proarrhythmic reactions to drugs employed in the treatment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e75a21209bb74e6199b08057de45aa0
https://doi.org/10.1016/j.tcm.2020.08.002

SARS-CoV-2, Zika viruses and mycoplasma: Structure, pathogenesis and some treatment options in these emerging viral and bacterial infectious diseases

Autor: Gonzalo Ferreira, Mariana Guirado, Garth L. Nicolson, Florencia Savio, Axel Santander, Luis Sobrevia

Publikováno v: Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Biochimica et Biophysica Acta. Molecular Basis of Disease
Biochimica et Biophysica Acta-Molecular Basis of Disease, 1867(12):166264. ELSEVIER SCIENCE BV

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Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74138c46cacbe2627e0f4293da6b884d