Zobrazeno 1 - 10
of 647
pro vyhledávání: '"CPT1a"'
Publikováno v:
Cancer Biology & Therapy, Vol 25, Iss 1 (2024)
Succinylation modification involves in the progression of human cancers. The present study aimed to investigate the role of CPT1A, which is a succinyltransferase in the progression of prostate cancer (PCa). CCK-8 was used to detect the cell viability
Externí odkaz:
https://doaj.org/article/cb5ecdfdd8e545689f50e93157a10ffb
Autor:
Zhenhui Chen, Lu Yu, Zhihao Zheng, Xusheng Wang, Qiqing Guo, Yuchuan Chen, Yaowei Zhang, Yuqin Zhang, Jianbiao Xiao, Keli Chen, Hongying Fan, Yi Ding
Publikováno v:
eLife, Vol 13 (2024)
The prevalence and mortality rates of colorectal cancer (CRC) are increasing worldwide. Radiation resistance hinders radiotherapy, a standard treatment for advanced CRC, leading to local recurrence and metastasis. Elucidating the molecular mechanisms
Externí odkaz:
https://doaj.org/article/56fd73c07c3e4a80a32e6138f850a1e2
Autor:
Lin, Yang-Hsiang a, b, ⁎, Chen, Cheng-Yi c, Chi, Hsiang-Cheng d, e, Wu, Meng-Han b, Lai, Ming-Wei a, f, Yeh, Chau-Ting a, g, ⁎
Publikováno v:
In Translational Oncology February 2025 52
Autor:
Asia Saorin, Gloria Saorin, Fahriye Duzagac, Pietro Parisse, Ni Cao, Giuseppe Corona, Enrico Cavarzerani, Flavio Rizzolio
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Amiodarone repositioning in cancer treatment is promising, however toxicity limits seem to arise, constraining its exploitability. Notably, amiodarone has been investigated for the treatment of ovarian cancer, a tumour known for metastasizin
Externí odkaz:
https://doaj.org/article/33e4fa2a147a45faa365cb0ecdde7c5e
Autor:
Linjie Peng, Chang Wang, Shuangjin Yu, Qihao Li, Guobin Wu, Weijie Lai, Jianliang Min, Guodong Chen
Publikováno v:
Lipids in Health and Disease, Vol 23, Iss 1, Pp 1-14 (2024)
Abstract Background Interstitial fibrosis and tubular atrophy (IF/TA), a histologic feature of kidney allograft destruction, is linked to decreased allograft survival. The role of lipid metabolism is well-acknowledged in the area of chronic kidney di
Externí odkaz:
https://doaj.org/article/8662e3f159404671aca4c977b9ead529
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 29, Iss 11, p 387 (2024)
Background: Macrophage polarization is involved in the development of ulcerative colitis (UC). This study investigated the mechanism by which high mobility group box-1 protein (HMGB1) regulates macrophage polarization through metabolic reprogramming,
Externí odkaz:
https://doaj.org/article/e803945627e74e7d9b46de781d069b08
Autor:
Qing-Hua Qian, Ya-Ping Song, Yu Zhang, Hao Xue, Wei-Wei Zhang, Yapeng Han, Yán Wāng, De-Xiang Xu
Publikováno v:
Environment International, Vol 185, Iss , Pp 108488- (2024)
Inorganic trivalent arsenic (iAsⅢ) at environmentally relevant levels has been found to cause developmental toxicity. Maternal exposure to iAsⅢ leads to enduring hepatic lipid deposition in later adult life. However, the exact mechanism in iAsⅢ
Externí odkaz:
https://doaj.org/article/c820b3380e64482c9d4f013ede03f1c8
Autor:
Kuei-Pin Chung, Jia-Ying Su, Yi-Fu Wang, Bugi Ratno Budiarto, Yu-Chang Yeh, Jui-Chen Cheng, Li-Ta Keng, Yi-Jung Chen, Ya-Ting Lu, Yi-Hsiu Juan, Kiichi Nakahira, Sheng-Yuan Ruan, Jung-Yien Chien, Hou-Tai Chang, Jih-Shuin Jerng, Yen-Tsung Huang, Shih-Yu Chen, Chong-Jen Yu
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Immunosuppression increases the risk of nosocomial infection in patients with chronic critical illness. This exploratory study aimed to determine the immunometabolic signature associated with nosocomial infection during chronic critical illness. We p
Externí odkaz:
https://doaj.org/article/203f011c9cd94ad7a338b0806a57c947
Publikováno v:
Acta Biochimica et Biophysica Sinica, Vol 55, Pp 758-768 (2023)
NQO1, a cytosolic enzyme, is closely related to the progression of cancers and poor outcome of cancer patients. However, the molecular biological mechanism of NQO1 tumorigenicity in pancreatic adenocarcinoma (PAAD) has not been clearly understood. In
Externí odkaz:
https://doaj.org/article/c04f9dcb3e244614b21076760f3b5d31
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 6, Pp 4665-4674 (2023)
Repositioning of aspirin for a more effective breast cancer (BC) treatment requires identification of predictive biomarkers. However, the molecular mechanism underlying the anticancer activity of aspirin remains fully undefined. Cancer cells enhance
Externí odkaz:
https://doaj.org/article/f37968e037ce45bdae63dd099a98c821