Zobrazeno 1 - 10
of 24
pro vyhledávání: '"CPP, Cell Penetrating Peptide"'
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 8, Pp 2416-2448 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 8, Pp 2416-2448 (2021)
Proteins and peptides (PPs) have gradually become more attractive therapeutic molecules than small molecular drugs due to their high selectivity and efficacy, but fewer side effects. Owing to the poor stability and limited permeability through gastro
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 7, Pp 1789-1812 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Due to its safety, convenience, low cost and good compliance, oral administration attracts lots of attention. However, the efficacy of many oral drugs is limited to their unsatisfactory bioavailability in the gastrointestinal tract. One of the critic
Publikováno v:
Biochemistry and Biophysics Reports, Vol 27, Iss, Pp 101101-(2021)
Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports
Calpains are Ca2+-dependent cysteine proteases; their aberrant activation is associated with several neurodegenerative diseases. The μ-calpain catalytic subunit, calpain-1, is located in the cytoplasm as well as in the mitochondria. Mitochondrial ca
Autor:
Ammar Achour
Publikováno v:
Biomedicine & Pharmacotherapy
Biomedicine & Pharmacotherapy, Vol 141, Iss, Pp 111722-(2021)
Biomedicine & Pharmacotherapy, Vol 141, Iss, Pp 111722-(2021)
Coronavirus disease 2019 is associated with clinical symptoms including severe inflammatory syndrome and a higher expression of angiotensin II. As a pro-inflammatory mediator, the physiologic effects of angiotensin II are mediated by a G-protein coup
Autor:
George Frimpong Boafo, Zhongjian Chen, Marwa Ahmed Sallam, Qingqing Xiao, Makhloufi Zoulikha, Wei He
Publikováno v:
Acta Pharmaceutica Sinica. B
The use of small interfering RNAs (siRNAs) has been under investigation for the treatment of several unmet medical needs, including acute lung injury/acute respiratory distress syndrome (ALI/ARDS) wherein siRNA may be implemented to modify the expres
Publikováno v:
The Journal of Biological Chemistry
Ral GTPases have been implicated as critical drivers of cell growth and metastasis in numerous Ras-driven cancers. We have previously reported stapled peptides, based on the Ral effector RLIP76, that can disrupt Ral signaling. Stapled peptides are sh
Autor:
Samir El Andaloussi, Tarek Magdy, Kariem Ezzat, Ramy El-Sayed, Taavi Lehto, C. I. Edvard Smith, Ülo Langel, Eman M. Zaghloul
Publikováno v:
Journal of Controlled Release
Cell-penetrating peptides (CPPs) are short cationic peptides that have been extensively studied as drug delivery vehicles for proteins, nucleic acids and nanoparticles. However, the formulation of CPP-based therapeutics into different pharmaceutical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b00578504134a785a309b717587457b
https://ora.ox.ac.uk/objects/uuid:2ade086b-dc53-4a43-aa76-bc3d3621e071
https://ora.ox.ac.uk/objects/uuid:2ade086b-dc53-4a43-aa76-bc3d3621e071
Autor:
Katharina Bruno
Publikováno v:
Advanced Drug Delivery Reviews
SiRNA is the trigger of RNA interference, a mechanism discovered in the late 1990s. To release the therapeutic potential of this versatile but large and fragile molecule, excipients are used which either interact by electrostatic interaction, passive
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 9, Iss 7, Pp 1276-1320 (2008)
International Journal of Molecular Sciences, Vol 9, Iss 7, Pp 1276-1320 (2008)
Despite the fact that non-viral nucleic acid delivery systems are generally considered to be less efficient than viral vectors, they have gained much interest in recent years due to their superior safety profile compared to their viral counterpart. A
Publikováno v:
Cell-Penetrating Peptides
Over the past two decades, cell-penetrating peptides (CPPs) have become increasingly popular both in research and in application. There have been numerous studies on the physiochemical characteristics and behavior of CPPs in various environments; lik