Zobrazeno 1 - 10 of 195 pro vyhledávání: '"CP Downes"'
1
Inhibition of human erythrocyte membrane phosphatidylinositol 4-kinase by phospholipid analogues
Autor: R. C. Young, CP Downes, KK Rana, M Jones, KJ Milliner, JG Ward
Publikováno v: European Journal of Medicinal Chemistry. 29:537-549
Analogues of phosphatidylinositol (Ptdlns, 1 ) have been synthesized to investigate the structural requirements for inhibition of a Ptdlns 4-kinase obtained from human erythrocyte membranes. While the presence of either D-1 or D-3 stereochemistry in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c2cbe40e4157b6c5a21e98e7ca0e912f
https://doi.org/10.1016/0223-5234(94)90146-5
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2
Total synthesis of the four stereoisomers of dihexadecanoyl phosphatidylinositol and the substrate stereospecificity of human erythrocyte membrane phosphatidylinositol 4-kinase
Autor: Eggleston Ds, CP Downes, Martin Jones, C.H. Macphee, Kishore K. Rana, Rodney C. Young, John G. Ward
Publikováno v: Journal of Medicinal Chemistry. 33:641-646
A new and convenient method for the preparation of the four stereoisomers of dihexadecanoyl phosphatidylinositol has been developed. An enantiomeric pair of acid-labile, pentaprotected myo-inositol building blocks was synthesized in high yield and co
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c76041d1448c00dcb03f05a241d4f85c
https://doi.org/10.1021/jm00164a027
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3
Catalytic domain of phosphoinositide-specific phospholipase C (PLC). Mutational analysis of residues within the active site and hydrophobic ridge of plcdelta1
Autor: Mv, Ellis, Sr, James, Perisic O, Cp, Downes, Roger Williams, Katan M
Publikováno v: Europe PubMed Central
Structural studies of phospholipase C delta1 (PLCdelta1) in complexes with the inositol-lipid headgroup and calcium identified residues within the catalytic domain that could be involved in substrate recognition, calcium binding, and catalysis. In ad
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::9fb0700db6c358c313bd0581ffede54b
https://pubmed.ncbi.nlm.nih.gov/9565585
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4
A G-protein beta gamma-subunit-responsive phosphoinositide 3-kinase activity in human platelet cytosol
Autor: Peter Thomason, Sr, James, Pj, Casey, Cp, Downes
Publikováno v: Europe PubMed Central
Thrombin activates phosphoinositide 3-kinase (PI 3-kinase) in platelets via a mechanism involving G-proteins, possibly of both the heterotrimeric and the low molecular weight families. We have investigated the regulation of PI 3-kinase present in pla
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::bed7e111346a64aa66d1cfd9aa2388a1
https://pubmed.ncbi.nlm.nih.gov/8206965
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6
Phosphatidylinositol 4,5-bisphosphate hydrolysis in turkey erythrocytes is regulated by P2y purinoceptors
Autor: Cp, Berrie, Pt, Hawkins, len stephens, Tk, Harden, Cp, Downes
Publikováno v: Europe PubMed Central
When intact [3H]inositol-loaded turkey erythrocytes were stimulated with the purinergic agonist ADP, there was a rapid increase (2.5-fold after 30 sec) in the intracellular content of [3H]inositol 1,4,5-trisphosphate, followed by increases in the lev
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::853afbac8188b80d03828265fbfebf17
https://pubmed.ncbi.nlm.nih.gov/2539559
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7
Turkey erythrocyte membranes as a model for regulation of phospholipase C by guanine nucleotides
Autor: Tk, Harden, len stephens, Pt, Hawkins, Cp, Downes
Publikováno v: Europe PubMed Central
Phosphoinositides of human, rabbit, rat, and turkey erythrocytes were radiolabeled by incubation of intact cells with [32P]Pi. Guanosine 5'-O-(thiotriphosphate) (GTP gamma S) and NaF, which are known activators of guanine nucleotide regulatory protei
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::29cc674befd4bd4dd0e5c06927298734
https://pubmed.ncbi.nlm.nih.gov/3036841
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8
Akademický článek
IQGAP proteins reveal an atypical phosphoinositide (aPI) binding domain with a pseudo C2 domain fold.
Autor: Dixon MJ; Division of Cell Signalling and Immunology, College of Life Sciences, University of Dundee, Dow St., Dundee DD1 5EH, Scotland, United Kingdom., Gray A, Schenning M, Agacan M, Tempel W, Tong Y, Nedyalkova L, Park HW, Leslie NR, van Aalten DM, Downes CP, Batty IH
Publikováno v: The Journal of biological chemistry [J Biol Chem] 2012 Jun 29; Vol. 287 (27), pp. 22483-96. Date of Electronic Publication: 2012 Apr 05.
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9
Akademický článek
A screen for novel phosphoinositide 3-kinase effector proteins.
Autor: Dixon MJ; The Division of Molecular Physiology, College of Life Sciences, University of Dundee, Dow St., Dundee, DD1 5EH, Scotland, UK., Gray A, Boisvert FM, Agacan M, Morrice NA, Gourlay R, Leslie NR, Downes CP, Batty IH
Publikováno v: Molecular & cellular proteomics : MCP [Mol Cell Proteomics] 2011 Apr; Vol. 10 (4), pp. M110.003178. Date of Electronic Publication: 2011 Jan 24.
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10
Akademický článek
Ubiquitination of PTEN (phosphatase and tensin homolog) inhibits phosphatase activity and is enhanced by membrane targeting and hyperosmotic stress.
Autor: Maccario H; Division of Molecular Physiology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom., Perera NM, Gray A, Downes CP, Leslie NR
Publikováno v: The Journal of biological chemistry [J Biol Chem] 2010 Apr 23; Vol. 285 (17), pp. 12620-8. Date of Electronic Publication: 2010 Feb 22.
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