Novel therapies for cancer-induced bone pain.

Autor: Haroun R; Molecular Nociception Group, Wolfson Institute for Biomedical Research (WIBR), University College London (UCL), London WC1E 6BT, United Kingdom., Gossage SJ; Molecular Nociception Group, Wolfson Institute for Biomedical Research (WIBR), University College London (UCL), London WC1E 6BT, United Kingdom., Iseppon F; Molecular Nociception Group, Wolfson Institute for Biomedical Research (WIBR), University College London (UCL), London WC1E 6BT, United Kingdom., Fudge A; Molecular Nociception Group, Wolfson Institute for Biomedical Research (WIBR), University College London (UCL), London WC1E 6BT, United Kingdom., Caxaria S; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom., Arcangeletti M; Molecular Nociception Group, Wolfson Institute for Biomedical Research (WIBR), University College London (UCL), London WC1E 6BT, United Kingdom., Leese C; Department of Biomedical Science, University of Sheffield, South Yorkshire S10 2TN, United Kingdom., Davletov B; Department of Biomedical Science, University of Sheffield, South Yorkshire S10 2TN, United Kingdom., Cox JJ; Molecular Nociception Group, Wolfson Institute for Biomedical Research (WIBR), University College London (UCL), London WC1E 6BT, United Kingdom., Sikandar S; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom., Welsh F; AstraZeneca BioPharmaceuticals R&D, Neuroscience, Discovery Centre, Biomedical campus, 1 Francis Crick Ave, Cambridge CB2 0AA, United Kingdom., Chessell IP; AstraZeneca BioPharmaceuticals R&D, Neuroscience, Discovery Centre, Biomedical campus, 1 Francis Crick Ave, Cambridge CB2 0AA, United Kingdom., Wood JN; Molecular Nociception Group, Wolfson Institute for Biomedical Research (WIBR), University College London (UCL), London WC1E 6BT, United Kingdom.

Publikováno v: Neurobiology of pain (Cambridge, Mass.) [Neurobiol Pain] 2024 Sep 26; Vol. 16, pp. 100167. Date of Electronic Publication: 2024 Sep 26 (Print Publication: 2024).

Out of the dark: the emerging roles of lncRNAs in pain.

Autor: Habib AM; College of Medicine, QU Health, Qatar University, PO Box 2713, Doha, Qatar., Cox JJ; Wolfson Institute for Biomedical Research, Division of Medicine, University College London, London, WC1E 6BT, UK. Electronic address: j.j.cox@ucl.ac.uk., Okorokov AL; Wolfson Institute for Biomedical Research, Division of Medicine, University College London, London, WC1E 6BT, UK. Electronic address: a.okorokov@ucl.ac.uk.

Publikováno v: Trends in genetics : TIG [Trends Genet] 2024 Aug; Vol. 40 (8), pp. 694-705. Date of Electronic Publication: 2024 Jun 25.

Genetic landscape of congenital insensitivity to pain and hereditary sensory and autonomic neuropathies.

Autor: Lischka A; Institute for Human Genetics and Genomic Medicine, Medical Faculty, RWTH Aachen University Hospital, 52074 Aachen, Germany., Eggermann K; Institute for Human Genetics and Genomic Medicine, Medical Faculty, RWTH Aachen University Hospital, 52074 Aachen, Germany., Record CJ; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK., Dohrn MF; Department of Neurology, Medical Faculty of the RWTH Aachen University, 52074 Aachen, Germany.; Dr. John T. Macdonald Foundation, Department of Human Genetics and John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, FL 33136, USA., Laššuthová P; Department of Paediatric Neurology, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital, 150 06 Praha, Czechia., Kraft F; Institute for Human Genetics and Genomic Medicine, Medical Faculty, RWTH Aachen University Hospital, 52074 Aachen, Germany., Begemann M; Institute for Human Genetics and Genomic Medicine, Medical Faculty, RWTH Aachen University Hospital, 52074 Aachen, Germany., Dey D; Institute for Human Genetics and Genomic Medicine, Medical Faculty, RWTH Aachen University Hospital, 52074 Aachen, Germany., Eggermann T; Institute for Human Genetics and Genomic Medicine, Medical Faculty, RWTH Aachen University Hospital, 52074 Aachen, Germany., Beijer D; Dr. John T. Macdonald Foundation, Department of Human Genetics and John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, FL 33136, USA., Šoukalová J; Department of Medical Genetics, University Hospital Brno, 625 00 Brno, Czechia., Laura M; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK., Rossor AM; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK., Mazanec R; Department of Neurology, Faculty of Medicine, Charles University in Prague and Motol University Hospital, 150 06 Prague, Czechia., Van Lent J; Peripheral Neuropathy Research Group, Department of Biomedical Sciences, Institute Born Bunge, University of Antwerp, 2160 Antwerp, Belgium., Tomaselli PJ; Department of Neurosciences and Behaviour Sciences, Clinical Hospital of Ribeirão Preto, University of São Paulo, Ribeirão Preto, 14015-130, Brazil., Ungelenk M; Institute of Human Genetics, University Hospital Jena, 07747 Jena, Germany., Debus KY; Center for Molecular Biomedicine Institute for Biophysics, Friedrich-Schiller Universität Jena, 07745 Jena, Germany., Feely SME; Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.; Division of Pediatric Neurology, Seattle Children's Hospital, University of Washington School of Medicine, Seattle, WA 98105, USA., Gläser D; Center for Human Genetics, Genetikum®, 89231 Neu-Ulm, Germany., Jagadeesh S; Department of Clinical Genetics and Genetic Counselling, Mediscan Systems, Chennai 600032, Tamilnadu, India., Martin M; Davis and Davis Children's Hospital, University of California, Sacramento, CA 95817, USA., Govindaraj GM; Department of Pediatrics, Government Medical College, Kozhikode, Kerala 673 008, India., Singhi P; Pediatric Neurology and Neurodevelopment, Medanta, The Medicity, Gurgaon, Haryana 122 001, India., Baineni R; Department of Pediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry 605 006, India., Biswal N; Department of Pediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry 605 006, India., Ibarra-Ramírez M; Genetics Department, Hospital Universitario Dr. José Eleuterio González Universidad Autónoma de Nuevo León, 64460 Monterrey, Nuevo León, México., Bonduelle M; Centre for Medical Genetics, Universitair Ziekenhuis Brussel, 1090 Jette, Brussels, Belgium., Gess B; Department of Neurology, Medical Faculty of the RWTH Aachen University, 52074 Aachen, Germany.; Department of Neurology, University Hospital, Evangelisches Klinikum Bethel, University of Bielefeld, 33617 Bielefeld, Germany., Romero Sánchez J; Pediatría, Clínica Premium, 29601 Marbella, Spain., Suthar R; Pediatric Neurology and Neurodevelopment Unit, Department of Pediatrics, Advanced Pediatric Centre, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh 160 012, India., Udani V; Department of Child Neurology, PD Hinduja Hospital and Medical Research Centre, Mumbai, Maharashtra 400 016, India., Nalini A; Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru 560 029, India., Unnikrishnan G; Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru 560 029, India., Marques W Junior; Department of Neurosciences and Behaviour Sciences, Clinical Hospital of Ribeirão Preto, University of São Paulo, Ribeirão Preto, 14015-130, Brazil., Mercier S; CHU Nantes, Service de Génétique Médicale, Centre de Référence des Maladies Neuromusculaires AOC, 44000 Nantes, France., Procaccio V; Department of Biochemistry and Genetics, MitoVasc Institute, UMR CNRS 6015- INSERM U1083, CHU Angers, 49055 Angers, France., Bris C; Department of Biochemistry and Genetics, MitoVasc Institute, UMR CNRS 6015- INSERM U1083, CHU Angers, 49055 Angers, France., Suresh B; Department of Clinical Genetics and Genetic Counselling, Mediscan Systems, Chennai 600032, Tamilnadu, India., Reddy V; Department of Clinical Genetics and Genetic Counselling, Mediscan Systems, Chennai 600032, Tamilnadu, India., Skorupinska M; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK., Bonello-Palot N; INSERM, MMG, U 1251, Marseille, France, Aix Marseille Univ, 13385 Marseille, France., Mochel F; Genetics Department, Sorbonne Université, Paris Brain Institute, APHP, INSERM, CNRS, 75013 Paris, France., Dahl G; Pediatric Neurology, Children's Hospital of the King's Daughters in Norfolk, Norfolk, VA 23507, USA., Sasidharan K; Department of Pediatrics, Government Medical College, Kozhikode, Kerala 673 008, India., Devassikutty FM; Department of Pediatrics, Government Medical College, Kozhikode, Kerala 673 008, India., Nampoothiri S; Department of Pediatric Genetics, Amrita Institute of Medical Sciences and Research Center, Cochin, Kerala 682 041, India., Rodovalho Doriqui MJ; Department of Genetics, Hospital Infantil Doutor Juvêncio Mattos, São Luis, Maranhão 65015-460, Brazil., Müller-Felber W; Department of Neuropediatrics, Developmental Neurology and Social Pediatrics, LMU Campus Innenstadt, University of Munich, 80337 Munich, Germany., Vill K; Department of Pediatric Neurology and Developmental Medicine, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, 80337 Munich, Germany.; Institute of Human Genetics, School of Medicine, Technical University of Munich, 81675 Munich, Germany., Haack TB; Institute of Medical Genetics and Applied Genomics, University of Tübingen, 72076 Tübingen, Germany., Dufke A; Institute of Medical Genetics and Applied Genomics, University of Tübingen, 72076 Tübingen, Germany., Abele M; Neurologie, Praxis für Neurologie und Schlafmedizin, 53359 Rheinbach, Germany., Stucka R; Friedrich Baur Institute at the Department of Neurology, LMU University Hospital, LMU Munich, 80336 Munich, Germany., Siddiqi S; Genomics Group, Institute of Biomedical and Genetic Engineering (IBGE), Islamabad 44000, Pakistan., Ullah N; Institute for Paramedical Sciences, Khyber Medical University, Peshawar, KPK 25100, Pakistan., Spranger S; MVZ Humangenetik Bremen, Limbach Genetics, 28209 Bremen, Germany., Chiabrando D; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center 'Guido Tarone', University of Torino, 10124 Turin, Italy., Bolgül BS; Department of Pedodontics, Faculty of Dentistry, Dicle University, 21200 Diyarbakir, Turkey., Parman Y; Neuromuscular Unit, Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, 34093 Istanbul, Turkey., Seeman P; Department of Paediatric Neurology, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital, 150 06 Praha, Czechia., Lampert A; Institute of Neurophysiology, Medical Faculty, Uniklinik RWTH Aachen University, 52074 Aachen, Germany., Schulz JB; Department of Neurology, Medical Faculty of the RWTH Aachen University, 52074 Aachen, Germany.; JARA-BRAIN Institute Molecular Neuroscience and Neuroimaging, Research Centre Jülich GmbH, and RWTH Aachen University, 52056 Aachen, Germany., Wood JN; Molecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK., Cox JJ; Molecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK., Auer-Grumbach M; Department of Orthopedics and Trauma Surgery, Medical University of Vienna, 1090 Vienna, Austria., Timmerman V; Peripheral Neuropathy Research Group, Department of Biomedical Sciences, Institute Born Bunge, University of Antwerp, 2160 Antwerp, Belgium., de Winter J; Translational Neurosciences and Institute Born Bunge, Faculty of Medicine and Health Sciences, University of Antwerp, 2610 Antwerp, Belgium.; Neuromuscular Reference Centre, Department of Neurology, Antwerp University Hospital, 2610 Antwerp, Belgium., Themistocleous AC; Nuffield Department of Clinical Neuroscience, University of Oxford, Oxford OX3 9DU, UK., Shy M; Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA., Bennett DL; Nuffield Department of Clinical Neuroscience, University of Oxford, Oxford OX3 9DU, UK., Baets J; Translational Neurosciences and Institute Born Bunge, Faculty of Medicine and Health Sciences, University of Antwerp, 2610 Antwerp, Belgium.; Neuromuscular Reference Centre, Department of Neurology, Antwerp University Hospital, 2610 Antwerp, Belgium., Hübner CA; Institute of Human Genetics, University Hospital Jena, 07747 Jena, Germany., Leipold E; Department of Anesthesiology and Intensive Care and CBBM-Center of Brain, Behavior and Metabolism, University of Luebeck, 23562 Luebeck, Germany., Züchner S; Dr. John T. Macdonald Foundation, Department of Human Genetics and John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, FL 33136, USA., Elbracht M; Institute for Human Genetics and Genomic Medicine, Medical Faculty, RWTH Aachen University Hospital, 52074 Aachen, Germany., Çakar A; Neuromuscular Unit, Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, 34093 Istanbul, Turkey., Senderek J; Friedrich Baur Institute at the Department of Neurology, LMU University Hospital, LMU Munich, 80336 Munich, Germany., Hornemann T; Department of Clinical Chemistry, University Hospital Zurich, University of Zurich, 8006 Zurich, Switzerland., Woods CG; Cambridge Institute for Medical Research, Keith Peters Building, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK., Reilly MM; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK., Kurth I; Institute for Human Genetics and Genomic Medicine, Medical Faculty, RWTH Aachen University Hospital, 52074 Aachen, Germany.

Publikováno v: Brain : a journal of neurology [Brain] 2023 Dec 01; Vol. 146 (12), pp. 4880-4890.

Molecular basis of FAAH-OUT-associated human pain insensitivity.

Autor: Mikaeili H; Molecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK., Habib AM; College of Medicine, QU Health, Qatar University, Doha, Qatar., Yeung CW; Molecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK., Santana-Varela S; Molecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK., Luiz AP; Molecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK., Panteleeva K; Molecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK., Zuberi S; Molecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK., Athanasiou-Fragkouli A; Department of Molecular Neuroscience, Institute of Neurology, University College London, London WC1N 3BG, UK., Houlden H; Department of Molecular Neuroscience, Institute of Neurology, University College London, London WC1N 3BG, UK., Wood JN; Molecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK., Okorokov AL; Molecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK., Cox JJ; Molecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK.

Publikováno v: Brain : a journal of neurology [Brain] 2023 Sep 01; Vol. 146 (9), pp. 3851-3865.

Pain-causing stinging nettle toxins target TMEM233 to modulate Na V 1.7 function.

Autor: Jami S; Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4072, Australia., Deuis JR; Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4072, Australia., Klasfauseweh T; Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4072, Australia., Cheng X; Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT, USA.; Rehabilitation Research Center, Veterans Affairs Connecticut Healthcare System, West Haven, CT, USA., Kurdyukov S; Dr. John and Anne Chong Lab for Functional Genomics, Charles Perkins Centre, Centenary Institute, University of Sydney, Camperdown, NSW, 2006, Australia., Chung F; Dr. John and Anne Chong Lab for Functional Genomics, Charles Perkins Centre, Centenary Institute, University of Sydney, Camperdown, NSW, 2006, Australia., Okorokov AL; Molecular Nociception Group, Wolfson Institute for Biomedical Research, Division of Medicine, University College London, Gower Street, London, WC1E 6BT, UK., Li S; Molecular Nociception Group, Wolfson Institute for Biomedical Research, Division of Medicine, University College London, Gower Street, London, WC1E 6BT, UK., Zhang J; Institute of Physics, Chinese Academy of Sciences, 100190, Beijing, P.R. China., Cristofori-Armstrong B; Centre for Advanced Imaging, The University of Queensland, St Lucia, QLD, 4072, Australia.; School of Biomedical Sciences, The University of Queensland, St Lucia, QLD, 4072, Australia., Israel MR; Wolfson Centre for Age-Related Diseases, Institute of Psychiatry, Psychology & Neuroscience, King's College London, SE1 1UL, London, UK., Ju RJ; Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4072, Australia., Robinson SD; Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4072, Australia., Zhao P; Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT, USA.; Rehabilitation Research Center, Veterans Affairs Connecticut Healthcare System, West Haven, CT, USA., Ragnarsson L; Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4072, Australia., Andersson Å; Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4072, Australia., Tran P; Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4072, Australia., Schendel V; Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4072, Australia., McMahon KL; Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4072, Australia., Tran HNT; Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4072, Australia., Chin YK; Centre for Advanced Imaging, The University of Queensland, St Lucia, QLD, 4072, Australia., Zhu Y; Centre for Advanced Imaging, The University of Queensland, St Lucia, QLD, 4072, Australia., Liu J; Centre for Advanced Imaging, The University of Queensland, St Lucia, QLD, 4072, Australia., Crawford T; Centre for Advanced Imaging, The University of Queensland, St Lucia, QLD, 4072, Australia., Purushothamvasan S; Centre for Advanced Imaging, The University of Queensland, St Lucia, QLD, 4072, Australia., Habib AM; College of Medicine, QU Health, Qatar University, PO Box 2713, Doha, Qatar., Andersson DA; Wolfson Centre for Age-Related Diseases, Institute of Psychiatry, Psychology & Neuroscience, King's College London, SE1 1UL, London, UK., Rash LD; School of Biomedical Sciences, The University of Queensland, St Lucia, QLD, 4072, Australia., Wood JN; Molecular Nociception Group, Wolfson Institute for Biomedical Research, Division of Medicine, University College London, Gower Street, London, WC1E 6BT, UK., Zhao J; Molecular Nociception Group, Wolfson Institute for Biomedical Research, Division of Medicine, University College London, Gower Street, London, WC1E 6BT, UK., Stehbens SJ; Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4072, Australia., Mobli M; Centre for Advanced Imaging, The University of Queensland, St Lucia, QLD, 4072, Australia., Leffler A; Department of Anesthesiology and Intensive Care Medicine, Hannover Medical School, Hannover, 30625, Germany., Jiang D; Institute of Physics, Chinese Academy of Sciences, 100190, Beijing, P.R. China., Cox JJ; Molecular Nociception Group, Wolfson Institute for Biomedical Research, Division of Medicine, University College London, Gower Street, London, WC1E 6BT, UK., Waxman SG; Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT, USA.; Rehabilitation Research Center, Veterans Affairs Connecticut Healthcare System, West Haven, CT, USA., Dib-Hajj SD; Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT, USA.; Rehabilitation Research Center, Veterans Affairs Connecticut Healthcare System, West Haven, CT, USA., Neely GG; Dr. John and Anne Chong Lab for Functional Genomics, Charles Perkins Centre, Centenary Institute, University of Sydney, Camperdown, NSW, 2006, Australia., Durek T; Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4072, Australia. t.durek@imb.uq.edu.au.; Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, St Lucia, QLD, 4072, Australia. t.durek@imb.uq.edu.au., Vetter I; Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4072, Australia. i.vetter@uq.edu.au.; School of Pharmacy, The University of Queensland, Woolloongabba, QLD, 4102, Australia. i.vetter@uq.edu.au.

Publikováno v: Nature communications [Nat Commun] 2023 Apr 28; Vol. 14 (1), pp. 2442. Date of Electronic Publication: 2023 Apr 28.