Zobrazeno 1 - 10
of 8 282
pro vyhledávání: '"COSTIMULATION"'
Autor:
Brendan L.C. Kinney, Brianna Brammer, Vikash Kansal, Connor J. Parrish, Haydn T. Kissick, Yuan Liu, Nabil F. Saba, Zachary S. Buchwald, Mark W. El-Deiry, Mihir R. Patel, Brian J. Boyce, Azeem S. Kaka, Jennifer H. Gross, H. Michael Baddour, Amy Y. Chen, Nicole C. Schmitt
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
T lymphocytes expressing CD57 and lacking costimulatory receptors CD27/CD28 have been reported to accumulate with aging, chronic infection, and cancer. These cells are described as senescent, with inability to proliferate but enhanced cytolytic and c
Externí odkaz:
https://doaj.org/article/3967eb4b36174a4b8c3720cf04420d75
Autor:
Ingo Winschel, Anne Willing, Jan Broder Engler, Mark Walkenhorst, Nina Meurs, Lars Binkle-Ladisch, Marcel S. Woo, Lena Kristina Pfeffer, Jana K. Sonner, Uwe Borgmeyer, Sven Hendrik Hagen, Benjamin Grünhagel, Janna M. Claussen, Marcus Altfeld, Manuel A. Friese
Publikováno v:
Biology of Sex Differences, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Background Differences in immune responses between women and men are leading to a strong sex bias in the incidence of autoimmune diseases that predominantly affect women, such as multiple sclerosis (MS). MS manifests in more than twice as ma
Externí odkaz:
https://doaj.org/article/567ad8ca738140ac904d3852d72995df
Publikováno v:
Transplant International, Vol 37 (2024)
Xenotransplantation of porcine hearts has become a promising alternative to human allotransplantation, where organ demand still greatly surpasses organ availability. Before entering the clinic, however, feasibility of cardiac xenotransplantation need
Externí odkaz:
https://doaj.org/article/ac08bcf1733743ecac24331bffb7acbd
Autor:
Veronika Mikolič, Jelica Pantović-Žalig, Špela Malenšek, Matjaž Sever, Duško Lainšček, Roman Jerala
Publikováno v:
Molecular Therapy: Oncology, Vol 32, Iss 2, Pp 200815- (2024)
Chimeric antigen receptor (CAR) T cell therapy has emerged as a powerful therapeutic approach against a range of hematologic malignancies. While the incorporation of CD28 or 4-1BB costimulatory signaling domains into CARs revolutionized immune respon
Externí odkaz:
https://doaj.org/article/9a53898250344751abd5d49ce41eb3c2
Autor:
Jerome C. Anyalebechi, Yini Sun, Carolyn Davis, Maylene E. Wagener, Zhe Liang, Eileen M. Burd, Craig M. Coopersmith, Mandy L. Ford
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionA hallmark of T cell dysregulation during sepsis is the downregulation of costimulatory molecules. CD28 is one of T cell costimulatory molecules significantly altered on memory T cells during sepsis. We recently showed that treatment with
Externí odkaz:
https://doaj.org/article/429754ade8b144558594280f7c10d7ec
Publikováno v:
Kidney International Reports, Vol 8, Iss 12, Pp 2529-2545 (2023)
Belatacept is the first costimulatory blockade agent clinically approved for transplant immunosuppression. Although more than 10 years of study have demonstrated that belatacept offers superior long-term renal allograft and patient survival compared
Externí odkaz:
https://doaj.org/article/c18be5862c2043f78b0c94ec30702556
Akademický článek
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Autor:
Richard Smith, Rhine Shen
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-10 (2023)
Abstract Chimeric antigen receptors (CARs) are engineered to target T cells specifically to tumor cells, resulting in the engineered T cell killing the tumor cell. This technology has been developed to target a range of cancers, with the most notable
Externí odkaz:
https://doaj.org/article/e62eb58919ca43ae861a8a08027b3fda
Autor:
Laura Rubio-Pérez, Susana Frago, Marta Compte, Rocío Navarro, Seandean L. Harwood, Rodrigo Lázaro-Gorines, Marina Gómez-Rosel, Oana Hangiu, Noelia Silva-Pilipich, Lucía Vanrell, Cristian Smerdou, Luis Álvarez-Vallina
Publikováno v:
Antibodies, Vol 13, Iss 2, p 34 (2024)
Immune checkpoint blockade has changed the treatment paradigm for advanced solid tumors, but the overall response rates are still limited. The combination of checkpoint blockade with anti-4-1BB antibodies to stimulate tumor-infiltrating T cells has s
Externí odkaz:
https://doaj.org/article/f4146a3dc0ce4049b9e43fa900b61edb
Autor:
Osman Dadas, Joel D. Allen, Sarah L. Buchan, Jinny Kim, H. T. Claude Chan, C. Ian Mockridge, Patrick J. Duriez, Anne Rogel, Max Crispin, Aymen Al-Shamkhani
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionT cell expressed CD27 provides costimulation upon binding to inducible membrane expressed trimeric CD70 and is required for protective CD8 T cell responses. CD27 agonists could therefore be used to bolster cellular vaccines and anti-tumou
Externí odkaz:
https://doaj.org/article/1b431c0777aa4151a8bb65c2e1304139