Zobrazeno 1 - 10
of 1 883
pro vyhledávání: '"COPY NUMBER ALTERATIONS"'
Autor:
Parastoo Shahrouzi, Youness Azimzade, Wioletta Brankiewicz-Kopcinska, Sugandha Bhatia, David Kunke, Derek Richard, Xavier Tekpli, Vessela N. Kristensen, Pascal H. G. Duijf
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-19 (2024)
Abstract Breast cancer (BCa) is a major global health challenge. The BCa genome often carries extensive somatic copy number alterations (CNAs), including gains/amplifications and losses/deletions. These CNAs significantly affect tumor development, dr
Externí odkaz:
https://doaj.org/article/7e2f096c8a0445e396e26529cad85b30
Autor:
Rim Rejaibi, Arnaud Guille, Maroua Manai, Jose Adelaide, Emilie Agavnian, Aida Jelassi, Raoudha Doghri, Emmanuelle Charafe-Jauffret, François Bertucci, Mohamed Manai, Karima Mrad, Lamia Charfi, Renaud Sabatier
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Ovarian cancer (OC) is one of the most common cancers in women, with a high mortality rate. Most of published studies have been focused on Caucasian populations, with the need to explore biological features and clinical outcomes of patients
Externí odkaz:
https://doaj.org/article/30285a921fbd4f2f8e43df5abf2491dd
Autor:
Serena Di Cosimo, Marco Silvestri, Cinzia De Marco, Alessia Calzoni, Maria Carmen De Santis, Maria Grazia Carnevale, Carolina Reduzzi, Massimo Cristofanilli, Vera Cappelletti
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract Chromosomal Instability (CIN) is a common and evolving feature in breast cancer. Large-scale Transitions (LSTs), defined as chromosomal breakages leading to gains or losses of at least 10 Mb, have recently emerged as a metric of CIN due to t
Externí odkaz:
https://doaj.org/article/5e21cc35fec64b789fb53b1caf488296
Autor:
Yingjie Zhu, Xin Pei, Ardijana Novaj, Jeremy Setton, Daniel Bronder, Fatemeh Derakhshan, Pier Selenica, Niamh McDermott, Mehmet Orman, Sarina Plum, Shyamal Subramanyan, Sara H. Braverman, Biko McMillan, Sonali Sinha, Jennifer Ma, Andrea Gazzo, Atif Khan, Samuel Bakhoum, Simon N. Powell, Jorge S. Reis-Filho, Nadeem Riaz
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-17 (2024)
Abstract Background Pathogenic BRCA1 or BRCA2 germline mutations contribute to hereditary breast, ovarian, prostate, and pancreatic cancer. Paradoxically, bi-allelic inactivation of BRCA1 or BRCA2 (bBRCA1/2) is embryonically lethal and decreases cell
Externí odkaz:
https://doaj.org/article/a99e307f304a411b854e096a6e780f20
Autor:
Medha Suman, Maja Löfgren, Susanne Fransson, Jewahri Idris Yousuf, Johanna Svensson, Anna Djos, Tommy Martinsson, Per Kogner, Teresia Kling, Helena Carén
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-25 (2024)
Abstract Background Neuroblastoma (NB) is a complex disease, and the current understanding of NB biology is limited. Deregulation in genomic imprinting is a common event in malignancy. Since imprinted genes play crucial roles in early fetal growth an
Externí odkaz:
https://doaj.org/article/4d33e6752f68449d9e475c908b6d3e32
Autor:
Valeria Tosello, Angela Grassi, Dominic Rose, Loc Carlo Bao, Elisabetta Zulato, Chiara Dalle Fratte, Maurizio Polano, Paola Del Bianco, Giulia Pasello, Valentina Guarneri, Stefano Indraccolo, Laura Bonanno
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Liquid biopsy has recently emerged as an important tool in clinical practice particularly for lung cancer patients. We retrospectively evaluated cell-free DNA analyses performed at our Institution by next generation sequencing methodology de
Externí odkaz:
https://doaj.org/article/aafccb68c79c428c82556566c94013f3
Autor:
Yi Chen, Yanhong Su, Xiaofang Cao, Ioannis Siavelis, Isabelle Rose Leo, Jianming Zeng, Panagiotis Tsagkozis, Asle C. Hesla, Andri Papakonstantinou, Xiao Liu, Wen‐Kuan Huang, Binbin Zhao, Cecilia Haglund, Monika Ehnman, Henrik Johansson, Yingbo Lin, Janne Lehtiö, Yifan Zhang, Olle Larsson, Xuexin Li, Felix Haglund de Flon
Publikováno v:
Advanced Science, Vol 11, Iss 41, Pp n/a-n/a (2024)
Abstract Synovial Sarcomas (SS) are characterized by the presence of the SS18::SSX fusion gene, which protein product induce chromatin changes through remodeling of the BAF complex. To elucidate the genomic events that drive phenotypic diversity in S
Externí odkaz:
https://doaj.org/article/a92fdeab1af74869a4e266ed68f3cd22
Autor:
Miguel Sogbe, Idoia Bilbao, Francesco P. Marchese, Jon Zazpe, Annarosaria De Vito, Marta Pozuelo, Delia D’Avola, Mercedes Iñarrairaegui, Carmen Berasain, Maria Arechederra, Josepmaria Argemi, Bruno Sangro
Publikováno v:
Clinical and Molecular Hepatology, Vol 30, Iss 2, Pp 177-190 (2024)
Background/Aims New prognostic markers are needed to identify patients with hepatocellular carcinoma (HCC) who carry a worse prognosis. Ultra-low-pass whole-genome sequencing (ULP-WGS) (≤0.5× coverage) of cell-free DNA (cfDNA) has emerged as a low
Externí odkaz:
https://doaj.org/article/208518fea3204466ae05f9ee501d23d6
Autor:
Sanaz Jamalzadeh, Jun Dai, Kari Lavikka, Yilin Li, Jing Jiang, Kaisa Huhtinen, Anni Virtanen, Jaana Oikkonen, Sakari Hietanen, Johanna Hynninen, Anna Vähärautio, Antti Häkkinen, Sampsa Hautaniemi
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-14 (2024)
Abstract Copy-number alterations (CNAs) are a hallmark of cancer and can regulate cancer cell states via altered gene expression values. Herein, we have developed a copy-number impact (CNI) analysis method that quantifies the degree to which a gene e
Externí odkaz:
https://doaj.org/article/49e9e8d08ec34660ad3ed7346f570610
Autor:
Héctor Herrera-Orozco, Verónica García-Castillo, Eduardo López-Urrutia, Antonio Daniel Martinez-Gutierrez, Eloy Pérez-Yepez, Oliver Millán-Catalán, David Cantú de León, César López-Camarillo, Nadia J. Jacobo-Herrera, Mauricio Rodríguez-Dorantes, Rosalío Ramos-Payán, Carlos Pérez-Plasencia
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 12, Pp 9549-9565 (2023)
Colorectal cancer (CRC) represents the second deadliest malignancy worldwide. Around 75% of CRC patients exhibit high levels of chromosome instability that result in the accumulation of somatic copy number alterations. These alterations are associate
Externí odkaz:
https://doaj.org/article/b1802939daaf41058e4b16337465248c