Zobrazeno 1 - 10
of 7 814
pro vyhledávání: '"COMT"'
Autor:
Angela Mikaczo, Csaba Papp, Tamas Erdei, Aniko Posa, Gabor Zahuczky, Csaba Varga, Janos Szabo, Rudolf Gesztelyi, Maria Szilasi, Judit Zsuga
Publikováno v:
BMC Pulmonary Medicine, Vol 24, Iss 1, Pp 1-12 (2024)
Abstract Background Albeit smoking cessation has unequivocal health benefits, attempts to quit are not unanimous, even in patient populations at high risk for smoking-related diseases cessation. Allelic variations of enzymes involved in dopamine meta
Externí odkaz:
https://doaj.org/article/c0a2ae03fba8402d8bff37013d554321
Publikováno v:
Iranian Journal of Basic Medical Sciences, Vol 27, Iss 4, Pp 492-499 (2024)
Objective(s): Luteolin is a flavone that provides defense against myocardial ischemia/reperfusion (I/R) injury. However, this compound is subjected to methylation mediated by catechol-O-methyltransferase (COMT), thus influencing its pharmacological e
Externí odkaz:
https://doaj.org/article/d9fe2b639c094e0a8d05a14054fb47ee
Autor:
Amin Tajerian
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Parkinson's disease (PD) is a progressive neurodegenerative disorder affecting over 3% of those over 65. It's caused by reduced dopaminergic neurons and Lewy bodies, leading to motor and non-motor symptoms. The relationship between COMT gene
Externí odkaz:
https://doaj.org/article/8dda56b88f3049cebc6c9c6b779deff2
Autor:
Pei-Shan Hsu, Ching-Hsiung Liu, Ching-Ju Yang, Lin-Chien Lee, Wei-Chi Li, Hsiang-Tai Chao, Ming-Wei Lin, Li-Fen Chen, Jen-Chuen Hsieh
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
IntroductionPrimary dysmenorrhea (PDM), characterized by cyclic pain, may involve pain modulation within the reward system (RS). The Catechol-O-methyltransferase (COMT) Val158Met polymorphism, which significantly influences dopamine activity, is link
Externí odkaz:
https://doaj.org/article/1e1bbff7a90b4cc08dfa07551840a776
Publikováno v:
International Journal of Cognitive Research in Science, Engineering and Education, Vol 12, Iss 2 (2024)
The objective of our study was to investigate the genetic predictors of self-regulation and related characteristics indicative of a higher level of rational behavior control. The study 107 female participants aged between 22 and 52 years, with an ave
Externí odkaz:
https://doaj.org/article/4ebf890bbe6b4ab7b6121c318fdaa9ae
Autor:
Alexander Yu Rudenko, Sofia S. Mariasina, Anastasiia K. Bolikhova, Maxim V. Nikulin, Ratislav M. Ozhiganov, Vasiliy G. Vasil’ev, Yuri A. Ikhalaynen, Anastasia L. Khandazhinskaya, Maxim A. Khomutov, Peter V. Sergiev, Alex R. Khomutov, Vladimir I. Polshakov
Publikováno v:
Frontiers in Chemistry, Vol 12 (2024)
S-Adenosyl-l-methionine (SAM)-mediated methylation of biomolecules controls their function and regulates numerous vital intracellular processes. Analogs of SAM with a reporter group in place of the S-methyl group are widely used to study these proces
Externí odkaz:
https://doaj.org/article/77e58f40aa35434d87abbb35bd6ea9be
Publikováno v:
Molecular Systems Biology, Vol 20, Iss 5, Pp 481-505 (2024)
Abstract Multiplexed assays of variant effect are powerful methods to profile the consequences of rare variants on gene expression and organismal fitness. Yet, few studies have integrated several multiplexed assays to map variant effects on gene expr
Externí odkaz:
https://doaj.org/article/e3f9a0a3fd414444937ad4be2d5c08c9
Autor:
Radojević Branislava S., Jančić Ivan, Savić Miroslav M., Kostić Vladimir S., Dragašević-Mišković Nataša T.
Publikováno v:
Arhiv za farmaciju, Vol 74, Iss 1, Pp 23-37 (2024)
Catechol-O-methyltransferase (COMT) is one of the cardinal enzymes in the degradation of catecholamines and levodopa. Genetic variants of the COMT gene may affect COMT enzyme activity. The most examined COMT gene polymorphism is the nonsynonymous sin
Externí odkaz:
https://doaj.org/article/3a35ae44a6074d04b330534d58a170dd
Publikováno v:
BMC Plant Biology, Vol 24, Iss 1, Pp 1-16 (2024)
Abstract Background Caffeic acid O-methyltransferase (COMT) is a key enzyme that regulates melatonin synthesis and is involved in regulating the growth, development, and response to abiotic stress in plants. Tea plant is a popular beverage consumed w
Externí odkaz:
https://doaj.org/article/98da49f8158c4600a42947321a8dbdc2
Autor:
Fabrizio Stocchi, Paolo Barone, Roberto Ceravolo, Maria Francesca De Pandis, Leonardo Lopiano, Nicola Modugno, Alessandro Padovani, Manuela Pilleri, Alessandro Tessitore, Mario Zappia
Publikováno v:
Annals of Medicine, Vol 56, Iss 1 (2024)
AbstractBackground Oral levodopa remains the mainstay of treatment for Parkinson’s disease (PD). However, as PD progresses, response to treatment may fluctuate. Managing fluctuations can be demanding for clinicians and patients. There is a paucity
Externí odkaz:
https://doaj.org/article/702afcd4a74a4f599a04d871df252cc2