Zobrazeno 1 - 10 of 1 427 pro vyhledávání: '"COMPUTATIONAL AND SYSTEMS BIOLOGY"'
1
Deep proteome profiling reveals signatures of age and sex differences in paw skin and sciatic nerve of naïve mice
Autor: Xian, Feng, Sondermann, Julia Regina, Gomez Varela, David, Schmidt, Manuela
Publikováno v: eLife. 11
The age and sex of studied animals profoundly impact experimental outcomes in animal-based preclinical biomedical research. However, most preclinical studies in mice use a wide-spanning age range from 4 to 14 weeks and do not assess study parameters
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d680d630cb9c8e76bc157876dd353cb
https://doi.org/10.7554/elife.81431
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2
Decoding mechanism of action and sensitivity to drug candidates from integrated transcriptome and chromatin state
Autor: Caterina Carraro, Lorenzo Bonaguro, Jonas Schulte-Schrepping, Arik Horne, Marie Oestreich, Stefanie Warnat-Herresthal, Tim Helbing, Michele De Franco, Kristian Haendler, Sach Mukherjee, Thomas Ulas, Valentina Gandin, Richard Goettlich, Anna C Aschenbrenner, Joachim L Schultze, Barbara Gatto
Publikováno v: eLife 11, e78012 (2022). doi:10.7554/eLife.78012
eLife
Omics-based technologies are driving major advances in precision medicine, but efforts are still required to consolidate their use in drug discovery. In this work, we exemplify the use of multi-omics to support the development of 3-chloropiperidines,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::090dc51b6948c45cc517fe2b311769f1
https://doi.org/10.7554/elife.78012
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3
Disruption in structural–functional network repertoire and time-resolved subcortical fronto-temporoparietal connectivity in disorders of consciousness
Autor: Rajanikant Panda, Aurore Thibaut, Ane Lopez-Gonzalez, Anira Escrichs, Mohamed Ali Bahri, Arjan Hillebrand, Gustavo Deco, Steven Laureys, Olivia Gosseries, Jitka Annen, Prejaas Tewarie
Publikováno v: Panda, R, Thibaut, A, Lopez-Gonzalez, A, Escrichs, A, Bahri, M A, Hillebrand, A, Deco, G, Laureys, S, Gosseries, O, Annen, J & Tewarie, P 2022, ' Disruption in structural-functional network repertoire and time-resolved subcortical fronto-temporoparietal connectivity in disorders of consciousness ', eLife, vol. 11, e77462 . https://doi.org/10.7554/eLife.77462
eLife
eLife, 11:e77462. eLife Sciences Publications Limited
Understanding recovery of consciousness and elucidating its underlying mechanism is believed to be crucial in the field of basic neuroscience and medicine. Ideas such as the global neuronal workspace (GNW) and the mesocircuit theory hypothesize that
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca7feb61221c9159775ab558eddcd7c1
https://doi.org/10.7554/elife.77462
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4
Predicting bacterial promoter function and evolution from random sequences
Autor: Mato Lagator, Srdjan Sarikas, Magdalena Steinrueck, David Toledo-Aparicio, Jonathan P Bollback, Calin C Guet, Gašper Tkačik
Publikováno v: Lagator, M, Sarikas, S, Steinrueck, M, Toledo-Aparicio, D, Bollback, J P, Guet, C C & Tkačik, G 2022, ' Predicting bacterial promoter function and evolution from random sequences ', eLife, vol. 11, e64543 . https://doi.org/10.7554/eLife.64543
eLife, Vol 11 (2022)
eLife
Predicting function from sequence is a central problem of biology. Currently, this is possible only locally in a narrow mutational neighborhood around a wildtype sequence rather than globally from any sequence. Using random mutant libraries, we devel
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a9b1a658865f28ca7f4731d793475a7
https://doi.org/10.7554/elife.64543
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5
Personalized computational heart models with T1-mapped fibrotic remodeling predict sudden death risk in patients with hypertrophic cardiomyopathy
Autor: Ryan P O'Hara, Edem Binka, Adityo Prakosa, Stefan L Zimmerman, Mark J Cartoski, M Roselle Abraham, Dai-Yin Lu, Patrick M Boyle, Natalia A Trayanova
Publikováno v: eLife
eLife, Vol 11 (2022)
Hypertrophic cardiomyopathy (HCM) is associated with risk of sudden cardiac death (SCD) due to ventricular arrhythmias (VAs) arising from the proliferation of fibrosis in the heart. Current clinical risk stratification criteria inadequately identify
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34baf026dabce94f38c9411fe3072f9d
https://doi.org/10.7554/elife.73325
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6
A human-based multi-gene signature enables quantitative drug repurposing for metabolic disease
Autor: James A Timmons, Andrew Anighoro, Robert J Brogan, Jack Stahl, Claes Wahlestedt, David Gordon Farquhar, Jake Taylor-King, Claude-Henry Volmar, William E Kraus, Stuart M Phillips
Publikováno v: eLife
eLife, Vol 11 (2022)
Insulin resistance (IR) contributes to the pathophysiology of diabetes, dementia, viral infection, and cardiovascular disease. Drug repurposing (DR) may identify treatments for IR; however, barriers include uncertainty whether in vitro transcriptomic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e56dfb0bc54afc209a61ea4f7793834a
https://doi.org/10.7554/elife.68832
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7
Comprehensive interrogation of the ADAR2 deaminase domain for engineering enhanced RNA editing activity and specificity
Autor: Dhruva Katrekar, Yichen Xiang, Nathan Palmer, Anushka Saha, Dario Meluzzi, Prashant Mali
Publikováno v: eLife, Vol 11 (2022)
eLife
Adenosine deaminases acting on RNA (ADARs) can be repurposed to enable programmable RNA editing, however their exogenous delivery leads to transcriptome-wide off-targeting, and additionally, enzymatic activity on certain RNA motifs, especially those
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::016fe6f5110fa84d56b9a41b9cf785c7
https://escholarship.org/uc/item/8097r555
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8
Comment on ‘SARS-CoV-2 suppresses anticoagulant and fibrinolytic gene expression in the lung’
Autor: Ethan S FitzGerald, Amanda M Jamieson
Publikováno v: eLife
eLife, Vol 11 (2022)
Mast et al. analyzed transcriptome data derived from RNA-sequencing (RNA-seq) of COVID-19 patient bronchoalveolar lavage fluid (BALF) samples, as compared to BALF RNA-seq samples from a study investigating microbiome and inflammatory interactions in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f62b1c4f6531f1f3877e91b22f10edc2
http://europepmc.org/articles/PMC8752089
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9
The energetic basis for smooth human arm movements
Autor: Arthur D. Kuo, Tyler Cluff, Jeremy D. Wong
Publikováno v: eLife
eLife, Vol 10 (2021)
The central nervous system plans human reaching movements with stereotypically smooth kinematic trajectories and fairly consistent durations. Smoothness seems to be explained by accuracy as a primary movement objective, whereas duration seems to econ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c68f8bca74e01993091885356e6e57b
https://doi.org/10.7554/elife.68013
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10
Author-sourced capture of pathway knowledge in computable form using Biofactoid
Autor: Jeffrey V. Wong, Özgün Babur, Benjamin M. Gyori, Emek Demir, Augustin Luna, Chris Sander, Funda Durupinar, Igor Rodchenkov, Max Franz, Dylan Fong, John A. Bachman, Christian Dallago, Gary D. Bader, John M Giorgi, Metin Can Siper
Publikováno v: eLife, Vol 10 (2021)
eLife
Making the knowledge contained in scientific papers machine-readable and formally computable would allow researchers to take full advantage of this information by enabling integration with other knowledge sources to support data analysis and interpre
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f1c8fc197cd3a51c2a92d6ac4d8d168
https://elifesciences.org/articles/68292
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