Fuel-Driven Dynamic Combinatorial Peptide Libraries.

Autor: Späth F; School of Natural Sciences, Department of Bioscience, Technical University of Munich, Lichtenbergstrasse 4, 85748, Garching, Germany., Soria-Carrera H; School of Natural Sciences, Department of Bioscience, Technical University of Munich, Lichtenbergstrasse 4, 85748, Garching, Germany., Stasi M; School of Natural Sciences, Department of Bioscience, Technical University of Munich, Lichtenbergstrasse 4, 85748, Garching, Germany., Sastre J; School of Natural Sciences, Department of Bioscience, Technical University of Munich, Lichtenbergstrasse 4, 85748, Garching, Germany., Kriebisch BAK; School of Natural Sciences, Department of Bioscience, Technical University of Munich, Lichtenbergstrasse 4, 85748, Garching, Germany., Boekhoven J; School of Natural Sciences, Department of Bioscience, Technical University of Munich, Lichtenbergstrasse 4, 85748, Garching, Germany.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2024 Oct 14; Vol. 63 (42), pp. e202407424. Date of Electronic Publication: 2024 Sep 12.

Ternary Complex-Templated Dynamic Combinatorial Chemistry for the Selection and Identification of Homo-PROTACs.

Autor: Diehl CJ; Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, 1 James Lindsay Place, DD1 5JJ, Dundee, Scotland, U.K., Salerno A; Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, 1 James Lindsay Place, DD1 5JJ, Dundee, Scotland, U.K., Ciulli A; Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, 1 James Lindsay Place, DD1 5JJ, Dundee, Scotland, U.K.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2024 Jun 17; Vol. 63 (25), pp. e202319456. Date of Electronic Publication: 2024 May 16.

Accelerating ionizable lipid discovery for mRNA delivery using machine learning and combinatorial chemistry.

Autor: Li B; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. bw.li@utoronto.ca.; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. bw.li@utoronto.ca.; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada. bw.li@utoronto.ca.; Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada. bw.li@utoronto.ca.; Department of Chemistry, University of Toronto, Toronto, Ontario, Canada. bw.li@utoronto.ca.; Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada. bw.li@utoronto.ca., Raji IO; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Anesthesiology, Boston Children's Hospital, Boston, MA, USA., Gordon AGR; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Sun L; Department of Statistics, University of Michigan, Ann Arbor, MI, USA., Raimondo TM; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Oladimeji FA; Harvard and MIT Division of Health Science and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA., Jiang AY; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Varley A; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada., Langer RS; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Anesthesiology, Boston Children's Hospital, Boston, MA, USA.; Department of Statistics, University of Michigan, Ann Arbor, MI, USA.; Harvard and MIT Division of Health Science and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA., Anderson DG; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. dgander@mit.edu.; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. dgander@mit.edu.; Department of Anesthesiology, Boston Children's Hospital, Boston, MA, USA. dgander@mit.edu.; Department of Statistics, University of Michigan, Ann Arbor, MI, USA. dgander@mit.edu.; Harvard and MIT Division of Health Science and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA. dgander@mit.edu.; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA. dgander@mit.edu.

Publikováno v: Nature materials [Nat Mater] 2024 Jul; Vol. 23 (7), pp. 1002-1008. Date of Electronic Publication: 2024 May 13.

Solid-phase peptide synthesis in 384-well plates.

Autor: Schüttel M; Institute of Chemical Sciences and Engineering, School of Basic Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland., Will E; Institute of Chemical Sciences and Engineering, School of Basic Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland., Sangouard G; Institute of Chemical Sciences and Engineering, School of Basic Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland., Zarda A; Institute of Chemical Sciences and Engineering, School of Basic Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland., Habeshian S; Institute of Chemical Sciences and Engineering, School of Basic Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland., Nielsen AL; Institute of Chemical Sciences and Engineering, School of Basic Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland., Heinis C; Institute of Chemical Sciences and Engineering, School of Basic Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.

Publikováno v: Journal of peptide science : an official publication of the European Peptide Society [J Pept Sci] 2024 Apr; Vol. 30 (4), pp. e3555. Date of Electronic Publication: 2024 Jan 14.

Discovery of selective monosaccharide receptors via dynamic combinatorial chemistry.

Autor: Alena-Rodriguez M; School of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham, West Midlands, B15 2TT, UK. p.m.mendes@bham.ac.uk.; Department of Biological Chemistry, Institute for Advanced Chemistry of Catalonia, IQAC-CSIC, Jordi Girona 18-26, 08034 Barcelona, Spain., Fernandez-Villamarin M; School of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham, West Midlands, B15 2TT, UK. p.m.mendes@bham.ac.uk., Alfonso I; Department of Biological Chemistry, Institute for Advanced Chemistry of Catalonia, IQAC-CSIC, Jordi Girona 18-26, 08034 Barcelona, Spain., Mendes PM; School of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham, West Midlands, B15 2TT, UK. p.m.mendes@bham.ac.uk.

Publikováno v: Organic & biomolecular chemistry [Org Biomol Chem] 2024 May 15; Vol. 22 (19), pp. 3854-3859. Date of Electronic Publication: 2024 May 15.