Zobrazeno 1 - 10
of 10 911
pro vyhledávání: '"COLOCALIZATION"'
Autor:
Chen Luo, YaJing Zhang, QiFan Feng, KaiXin Yao, LeiLei Zheng, Ye Yang, WenXin Zheng, Feng Li, YongQiang Lv, Yue Cai
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Atopic dermatitis (AD) is an immune-related skin disease with a genetic background. Numerous loci have been identified associated with AD to better comprehend its complicated genetic mechanisms by genome‑wide association studies (GWASs). H
Externí odkaz:
https://doaj.org/article/b14f49c756904bc5889f75bbb48ce4a9
Autor:
Aitor González, Pascale Paul
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 4260-4270 (2024)
Integrating expression quantitative trait loci (eQTL) data with genome-wide association studies (GWAS) enables the discovery of pleiotropic gene regulatory variants that influence a wide range of traits and disease susceptibilities. However, a compre
Externí odkaz:
https://doaj.org/article/088cdd669e8a4aafae380a931c4e69ae
Autor:
Jothi Kumar Yuvaraj, Dineshkumar Kandasamy, Rebecca E. Roberts, Bill S. Hansson, Jonathan Gershenzon, Martin N. Andersson
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract Background Insects detect odours using odorant receptors (ORs) expressed in olfactory sensory neurons (OSNs) in the antennae. Ecologically important odours are often detected by selective and abundant OSNs; hence, ORs with high antennal expr
Externí odkaz:
https://doaj.org/article/7beba0c3a05644f9b0c6a6501bdac7ba
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Background Blood and urine biomarkers have been associated with urologic tumors, but their causal relationship with urologic tumors is unclear. Methods We performed a bidirectional Mendelian randomization (MR) analysis of the association bet
Externí odkaz:
https://doaj.org/article/b6c965186c63443da097c4f542a73ea7
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Benign prostatic hyperplasia (BPH) is a condition commonly observed in aging males. Inflammatory and metabolic factors are pivotal in the development and progression of BPH. The degree to which the effects of 91 inflammation-related proteins
Externí odkaz:
https://doaj.org/article/acbd27c2b8d8471d977fb84b68b1e01c
Autor:
Youshu Cheng, Biao Cai, Hongyu Li, Xinyu Zhang, Gypsyamber D’Souza, Sadeep Shrestha, Andrew Edmonds, Jacquelyn Meyers, Margaret Fischl, Seble Kassaye, Kathryn Anastos, Mardge Cohen, Bradley E. Aouizerat, Ke Xu, Hongyu Zhao
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-27 (2024)
Abstract Methylation quantitative trait loci (meQTLs) quantify the effects of genetic variants on DNA methylation levels. However, most published studies utilize bulk methylation datasets composed of different cell types and limit our understanding o
Externí odkaz:
https://doaj.org/article/c6b0a2734db1434f9dcd7daf066bd2c6
Autor:
Weihao Tang, Xiaoke Ma
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Purposes Gastric cancer (GC) is one of the most common malignant tumors threatening human beings and has a poor prognosis. Therefore, exploring unveiled biomarkers or therapeutic targets for the diagnosis and treatment of GC is crucial. Meth
Externí odkaz:
https://doaj.org/article/1f42739bb7c847e4ae680ede474e0e16
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-8 (2024)
Abstract Background Idiopathic pulmonary fibrosis (IPF) is a complex lung disease with a very poor prognosis. Existing drugs for the treatment of IPF are still insufficient. Therefore, there is still a need to explore new drug targets for preventing
Externí odkaz:
https://doaj.org/article/6bc14135a1aa445884af911e54b580a8
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Most advanced lung adenocarcinoma (LUAD) patient deaths are attributed to metastasis. However, the complete understanding of the metastatic mechanism in LUAD remains elusive. Single-cell RNA-seq (scRNA-seq), spatial RNA-seq (stRNA-seq) and b
Externí odkaz:
https://doaj.org/article/6e736454457e413482828ea08aa09279
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Chronic Kidney Disease (CKD) stands as a substantial challenge within the global health landscape. The elevated metabolic demands essential for sustaining normal kidney function have propelled an increasing interest in unraveling the intrica
Externí odkaz:
https://doaj.org/article/0c7f26c55c7c485cab25103e3a3a842a