Zobrazeno 1 - 10
of 410
pro vyhledávání: '"COLIN G. NICHOLS"'
Autor:
Grigory Maksaev, Michael Bründl-Jirout, Anna Stary-Weinzinger, Eva-Maria Zangerl-Plessl, Sun-Joo Lee, Colin G. Nichols
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Inwardly rectifying potassium (Kir) channels open at the ‘helix bundle crossing’ (HBC), formed by the M2 helices at the cytoplasmic end of the transmembrane pore. Introduced negative charges at the HBC (G178D) in Kir2.2 channels forces o
Externí odkaz:
https://doaj.org/article/13b6793a2f8e4b3ab216e0190876a3e2
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
The potassium channel selectivity filter is responsible for conduction and selectivity of K + over other cations. Here, the authors use a combination of single molecule FRET, non-canonical fluorescent amino acid incorporation, and single channel patc
Externí odkaz:
https://doaj.org/article/e8b7029b6af041a8a76dc3d32ea61615
Autor:
John Grizzanti, William R. Moritz, Morgan C. Pait, Molly Stanley, Sarah D. Kaye, Caitlin M. Carroll, Nicholas J. Constantino, Lily J. Deitelzweig, James A. Snipes, Derek Kellar, Emily E. Caesar, Ryan J. Pettit-Mee, Stephen M. Day, Jonathon P. Sens, Noelle I. Nicol, Jasmeen Dhillon, Maria S. Remedi, Drew D. Kiraly, Celeste M. Karch, Colin G. Nichols, David M. Holtzman, Shannon L. Macauley
Publikováno v:
JCI Insight, Vol 8, Iss 10 (2023)
Elevated blood glucose levels, or hyperglycemia, can increase brain excitability and amyloid-β (Aβ) release, offering a mechanistic link between type 2 diabetes and Alzheimer’s disease (AD). Since the cellular mechanisms governing this relationsh
Externí odkaz:
https://doaj.org/article/62f0275671b24363b2fe41c05f92976d
Autor:
Neil L. Harrison, Geoffrey W. Abbott, Martina Gentzsch, Andrei Aleksandrov, Anna Moroni, Gerhard Thiel, Stephen Grant, Colin G. Nichols, Henry A. Lester, Andreas Hartel, Kenneth Shepard, David Cabrera Garcia, Masayuki Yazawa
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-3 (2022)
Externí odkaz:
https://doaj.org/article/412f76ba93c044a085d835ada304e2f3
Autor:
Gautam K. Singh, Conor McClenaghan, Manish Aggarwal, Hongjie Gu, Maria S. Remedi, Dorothy K. Grange, Colin G. Nichols
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 24 (2022)
Background Cardiomegaly caused by left ventricular hypertrophy is a risk factor for development of congestive heart failure, classically associated with decreased systolic and/or diastolic ventricular function. Less attention has been given to the ph
Externí odkaz:
https://doaj.org/article/f9efc30b206147a6b06d6e40ddaa49da
Autor:
Rosa Scala, Fatima Maqoud, Conor McClenaghan, Theresa M. Harter, Maria Grazia Perrone, Antonio Scilimati, Colin G. Nichols, Domenico Tricarico
Publikováno v:
Cells, Vol 12, Iss 6, p 928 (2023)
Cantú syndrome (CS) is caused by the gain of function mutations in the ABCC9 and KCNJ8 genes encoding, respectively, for the sulfonylureas receptor type 2 (SUR2) and the inwardly rectifier potassium channel 6.1 (Kir6.1) of the ATP-sensitive potassiu
Externí odkaz:
https://doaj.org/article/6ee79164735747b6aa9bf1c7ad8fb9db
Autor:
Jan Benedikt, Christian J. Malpica-Nieves, Yomarie Rivera, Miguel Méndez-González, Colin G. Nichols, Rüdiger W. Veh, Misty J. Eaton, Serguei N. Skatchkov
Publikováno v:
Biomolecules, Vol 12, Iss 12, p 1812 (2022)
The interest in astrocytes, the silent brain cells that accumulate polyamines (PAs), is growing. PAs exert anti-inflammatory, antioxidant, antidepressant, neuroprotective, and other beneficial effects, including increasing longevity in vivo. Unlike n
Externí odkaz:
https://doaj.org/article/305c2b8783164569978c70182d29bd50
Autor:
Marie F. Smeland, Conor McClenaghan, Helen I. Roessler, Sanne Savelberg, Geir Åsmund Myge Hansen, Helene Hjellnes, Kjell Arne Arntzen, Kai Ivar Müller, Andreas Rosenberger Dybesland, Theresa Harter, Monica Sala-Rabanal, Chris H. Emfinger, Yan Huang, Soma S. Singareddy, Jamie Gunn, David F. Wozniak, Attila Kovacs, Maarten Massink, Federico Tessadori, Sarah M. Kamel, Jeroen Bakkers, Maria S. Remedi, Marijke Van Ghelue, Colin G. Nichols, Gijs van Haaften
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
ABCC9 encodes the SUR2 subunit of KATP channels and dominant genetic variants in ABCC9 have been associated with cardiac phenotypes. Here, the authors report recessive ABCC9 mutations in individuals with mild intellectual disability, myopathy and car
Externí odkaz:
https://doaj.org/article/3b16521767fb4e02b8c29af4d1962611
Autor:
Haixia Zhang, Alex Hanson, Tobias Scherf de Almeida, Christopher Emfinger, Conor McClenaghan, Theresa Harter, Zihan Yan, Paige E. Cooper, G. Schuyler Brown, Eric C. Arakel, Robert P. Mecham, Atilla Kovacs, Carmen M. Halabi, Blanche Schwappach, Maria S. Remedi, Colin G. Nichols
Publikováno v:
JCI Insight, Vol 6, Iss 5 (2021)
Cantu syndrome (CS) is caused by gain-of-function (GOF) mutations in pore-forming (Kir6.1, KCNJ8) and accessory (SUR2, ABCC9) ATP-sensitive potassium (KATP) channel subunits, the most common mutations being SUR2[R1154Q] and SUR2[R1154W], carried by a
Externí odkaz:
https://doaj.org/article/49205ba65db14c0c92f39428e2cf79af
Autor:
Nathaniel W. York, Helen Parker, Zili Xie, David Tyus, Maham Akbar Waheed, Zihan Yan, Dorothy K. Grange, Maria Sara Remedi, Sarah K. England, Hongzhen Hu, Colin G. Nichols
Publikováno v:
JCI Insight, Vol 5, Iss 23 (2020)
Cantú syndrome (CS), caused by gain-of-function (GOF) mutations in pore-forming (Kir6.1, KCNJ8) and accessory (SUR2, ABCC9) ATP-sensitive potassium (KATP) channel subunit genes, is frequently accompanied by gastrointestinal (GI) dysmotility, and we
Externí odkaz:
https://doaj.org/article/573f155ab6f149b99f5480cd8417f575