Effectiveness of rapid SARS-CoV-2 genome sequencing in supporting infection control for hospital-onset COVID-19 infection: Multicentre, prospective study

Autor: Oliver Stirrup, James Blackstone, Fiona Mapp, Alyson MacNeil, Monica Panca, Alison Holmes, Nicholas Machin, Gee Yen Shin, Tabitha Mahungu, Kordo Saeed, Tranprit Saluja, Yusri Taha, Nikunj Mahida, Cassie Pope, Anu Chawla, Maria-Teresa Cutino-Moguel, Asif Tamuri, Rachel Williams, Alistair Darby, David L Robertson, Flavia Flaviani, Eleni Nastouli, Samuel Robson, Darren Smith, Matthew Loose, Kenneth Laing, Irene Monahan, Beatrix Kele, Sam Haldenby, Ryan George, Matthew Bashton, Adam A Witney, Matthew Byott, Francesc Coll, Michael Chapman, Sharon J Peacock, COG-UK HOCI Investigators, The COVID-19 Genomics UK (COG-UK) consortium, Joseph Hughes, Gaia Nebbia, David G Partridge, Matthew Parker, James Richard Price, Christine Peters, Sunando Roy, Luke B Snell, Thushan I de Silva, Emma Thomson, Paul Flowers, Andrew Copas, Judith Breuer

Publikováno v: eLife, Vol 11 (2022)

Background: Viral sequencing of SARS-CoV-2 has been used for outbreak investigation, but there is limited evidence supporting routine use for infection prevention and control (IPC) within hospital settings. Methods: We conducted a prospective non-ran

Externí odkaz: https://doaj.org/article/379a33f72af04755abd517e33357f2c4

Factors affecting turnaround time of SARS-CoV-2 sequencing for inpatient infection prevention and control decision making: analysis of data from the COG-UK HOCI study

Autor: Colton, H, Parker, MD, Stirrup, O, Blackstone, J, Loose, M, McClure, CP, Roy, S, Williams, C, McLeod, J, Smith, D, Taha, Y, Zhang, P, Hsu, SN, Kele, B, Harris, K, Mapp, F, Williams, R, COG-UK HOCI Investigators, COVID-19 Genomics UK (COG-UK) Consortium, Flowers, P, Breuer, J, Partridge, DG, De Silva, TI

BACKGROUND: Barriers to rapid return of sequencing results can affect the utility of sequence data for infection prevention and control decisions. AIM: To undertake a mixed-methods analysis to identify challenges that sites faced in achieving a rapid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3889d7432fcead1ddb554a85a43abed3
https://www.repository.cam.ac.uk/handle/1810/343886

Effectiveness of rapid SARS-CoV-2 genome sequencing in supporting infection control for hospital-onset COVID-19 infection: multicenter, prospective study

Autor: Stirrup, O, Blackstone, J, Mapp, F, MacNeil, A, Panca, M, Holmes, A, Machin, N, Shin, GY, Mahungu, T, Saeed, K, Saluja, T, Taha, Y, Mahida, N, Pope, C, Chawla, A, Cutino-Moguel, M-T, Tamuri, A, Williams, R, Darby, A, Robertson, DL, Flaviani, F, Nastouli, E, Robson, S, Smith, D, Laing, K, Monahan, I, Kele, B, Haldenby, S, George, R, Bashton, M, Witney, AA, Byott, M, Coll, F, Chapman, M, Peacock, SJ, COG‐UK HOCI Investigators, COVID‐19 Genomics UK (COG‐UK) Consortium, Hughes, J, Nebbia, G, Partridge, DG, Parker, M, Price, JR, Peters, C, Roy, S, Snell, LB, de Silva, TI, Thomson, E, Flowers, P, Copas, A, Breuer, J

Background: Viral sequencing of SARS-CoV-2 has been used for outbreak investigation, but there is limited evidence supporting routine use for infection prevention and control (IPC) within hospital settings. Methods: We conducted a prospective non-ran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::31e62b136217a005d5c9956deb5a3126
https://openaccess.sgul.ac.uk/id/eprint/114881/1/elife-78427-v1.pdf

Effectiveness of rapid SARS-CoV-2 genome sequencing in supporting infection control for hospital-onset COVID-19 infection: Multicentre, prospective study.

Autor: Stirrup O; Institute for Global Health, University College London, London, United Kingdom., Blackstone J; The Comprehensive Clinical Trials Unit, University College London, London, United Kingdom., Mapp F; Institute for Global Health, University College London, London, United Kingdom., MacNeil A; The Comprehensive Clinical Trials Unit, University College London, London, United Kingdom., Panca M; The Comprehensive Clinical Trials Unit, University College London, London, United Kingdom., Holmes A; Imperial College Healthcare NHS Trust, London, United Kingdom., Machin N; Manchester University NHS Foundation Trust, Manchester, United Kingdom., Shin GY; University College London Hospitals NHS Foundation Trust, London, United Kingdom., Mahungu T; Royal Free London NHS Foundation Trust, London, United Kingdom., Saeed K; University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom., Saluja T; Sandwell & West Birmingham Hospitals NHS Trust, Birmingham, United Kingdom., Taha Y; Department of Virology and Infectious Diseases, Newcastle-upon-Tyne Hospitals NHS Foundation Trust, Newcastle, United Kingdom., Mahida N; Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom., Pope C; St George's University Hospitals NHS Foundation Trust, London, United Kingdom., Chawla A; Liverpool University Hospitals NHS Foundation Trust, Liverpool, United Kingdom., Cutino-Moguel MT; Barts Health NHS Trust, London, United Kingdom., Tamuri A; Research Computing, University College London, London, United Kingdom., Williams R; Department of Genetics and Genomic Medicine, UCL Great Ormond Street Institute of Child Health, University College London, London, United Kingdom., Darby A; Centre for Genomic Research, University of Liverpool, Liverpool, United Kingdom., Robertson DL; MRC-University of Glasgow Centre For Virus Research, University of Glasgow, Glasgow, United Kingdom., Flaviani F; Guy's and St Thomas' Hospital NHS Foundation Trust, London, United Kingdom., Nastouli E; University College London Hospitals NHS Foundation Trust, London, United Kingdom., Robson S; Centre for Enzyme Innovation and School of Pharmacy and Biomedical Science, University of Portsmouth, Portsmouth, United Kingdom., Smith D; Department of Applied Sciences, Northumbria University, Newcastle-upon-Tyne, United Kingdom., Loose M; School of Life Sciences, University of Nottingham, Nottingham, United Kingdom., Laing K; Institute for Infection and Immunity, St George's University of London, London, United Kingdom., Monahan I; Institute for Infection and Immunity, St George's University of London, London, United Kingdom., Kele B; Barts Health NHS Trust, London, United Kingdom., Haldenby S; Centre for Genomic Research, University of Liverpool, Liverpool, United Kingdom., George R; Manchester University NHS Foundation Trust, Manchester, United Kingdom., Bashton M; The Hub for Biotechnology in the Built Environment, Department of Applied Sciences, Northumbria University, Newcastle, United Kingdom., Witney AA; Institute for Infection and Immunity, St George's University of London, London, United Kingdom., Byott M; University College London Hospitals NHS Foundation Trust, London, United Kingdom., Coll F; Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom., Chapman M; Health Data Research UK Cambridge Hub, Cambridge, United Kingdom., Peacock SJ; Department of Medicine, University of Cambridge, Cambridge, United Kingdom., Hughes J; MRC-University of Glasgow Centre For Virus Research, University of Glasgow, Glasgow, United Kingdom., Nebbia G; Guy's and St Thomas' Hospital NHS Foundation Trust, London, United Kingdom., Partridge DG; Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom., Parker M; Sheffield Bioinformatics Core, University of Sheffield, Sheffield, United Kingdom., Price JR; Imperial College Healthcare NHS Trust, London, United Kingdom., Peters C; NHS Greater Glasgow and Clyde, Glasgow, United Kingdom., Roy S; Department of Infection, Immunity and Inflammation, UCL Great Ormond Street Institute of Child Health, University College London, London, United Kingdom., Snell LB; Guy's and St Thomas' Hospital NHS Foundation Trust, London, United Kingdom., de Silva TI; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom., Thomson E; MRC-University of Glasgow Centre For Virus Research, University of Glasgow, Glasgow, United Kingdom., Flowers P; School of Psychological Sciences and Health, University of Strathclyde, Glasgow, United Kingdom., Copas A; Institute for Global Health, University College London, London, United Kingdom., Breuer J; Department of Infection, Immunity and Inflammation, UCL Great Ormond Street Institute of Child Health, University College London, London, United Kingdom.

Publikováno v: ELife [Elife] 2022 Sep 13; Vol. 11. Date of Electronic Publication: 2022 Sep 13.