Zobrazeno 1 - 10
of 224
pro vyhledávání: '"CNS trauma"'
Publikováno v:
Journal of Advanced Research, Vol 40, Iss , Pp 125-134 (2022)
Background: Traumatic brain injury (TBI) and spinal cord injury (SCI) are capable of causing severe sensory, motor and autonomic nervous system dysfunctions. However, effective treatments for TBI and SCI are still unavailable, mainly because the deat
Externí odkaz:
https://doaj.org/article/3a874cba1b9e432397afe5e4919299a1
Autor:
Jana Van Broeckhoven, Céline Erens, Daniela Sommer, Elle Scheijen, Selien Sanchez, Pia M. Vidal, Dearbhaile Dooley, Elise Van Breedam, Alessandra Quarta, Peter Ponsaerts, Sven Hendrix, Stefanie Lemmens
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-19 (2022)
Abstract Background Spinal cord injury (SCI) elicits a robust neuroinflammatory reaction which, in turn, exacerbates the initial mechanical damage. Pivotal players orchestrating this response are macrophages (Mφs) and microglia. After SCI, the infla
Externí odkaz:
https://doaj.org/article/f0427bff6b854ed18b3bdea93717bfc4
Autor:
Minna Christiansen Lund, Ditte Gry Ellman, Pernille Vinther Nielsen, Stefano Raffaele, Marta Fumagalli, Raphael Guzman, Matilda Degn, Roberta Brambilla, Morten Meyer, Bettina Hjelm Clausen, Kate Lykke Lambertsen
Publikováno v:
Biology, Vol 12, Iss 6, p 845 (2023)
Clinical and animal model studies have implicated inflammation and glial and peripheral immune cell responses in the pathophysiology of spinal cord injury (SCI). A key player in the inflammatory response after SCI is the pleiotropic cytokine tumor ne
Externí odkaz:
https://doaj.org/article/61f3a400cf6841659491dca8791f30ae
Autor:
Yikui Zhang, Mengyun Li, Bo Yu, Shengjian Lu, Lujie Zhang, Senmiao Zhu, Zhonghao Yu, Tian Xia, Haoliang Huang, WenHao Jiang, Si Zhang, Lanfang Sun, Qian Ye, Jiaying Sun, Hui Zhu, Pingping Huang, Huifeng Hong, Shuaishuai Yu, Wenjie Li, Danni Ai, Jingfan Fan, Wentao Li, Hong Song, Lei Xu, Xiwen Chen, Tongke Chen, Meng Zhou, Jingxing Ou, Jian Yang, Wei Li, Yang Hu, Wencan Wu
Publikováno v:
eLife, Vol 11 (2022)
Therapeutic hypothermia (TH) is potentially an important therapy for central nervous system (CNS) trauma. However, its clinical application remains controversial, hampered by two major factors: (1) Many of the CNS injury sites, such as the optic nerv
Externí odkaz:
https://doaj.org/article/88fc6c5e24784933a5beb7db12d036a2
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Central nervous system (CNS) trauma, including traumatic brain injury (TBI) and traumatic spinal cord injury (SCI), is characterized by high morbidity, disability, and mortality. TBI and SCI have similar pathophysiological mechanisms and are often ac
Externí odkaz:
https://doaj.org/article/53dce855dead484cbaa4626081dab1d3
Autor:
Xinli Hu, Yu Xu, Hui Xu, Chenqiang Jin, Haojie Zhang, Haohan Su, Yao Li, Kailiang Zhou, Wenfei Ni
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Acute central nervous system (CNS) trauma, including spinal cord injury (SCI) and traumatic brain injury (TBI), always leads to severe sensory, motor and autonomic nervous system dysfunction due to a series of processes, including cell death, oxidati
Externí odkaz:
https://doaj.org/article/70910dc7e2f24582af89fbd0a8b11dcb
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
The central nervous system (CNS) undergoes immunosurveillance despite the lack of conventional antigen presenting cells and lymphatic vessels in the CNS parenchyma. Additionally, the CNS is bathed in a cerebrospinal fluid (CSF). CSF is continuously p
Externí odkaz:
https://doaj.org/article/857980c654af458f9e4e5ee24dec8273
Autor:
Céline Erens, Jana Van Broeckhoven, Cindy Hoeks, Gernot Schabbauer, Paul N. Cheng, Li Chen, Niels Hellings, Bieke Broux, Stefanie Lemmens, Sven Hendrix
Publikováno v:
Biomedicines, Vol 10, Iss 2, p 205 (2022)
Background: Spinal cord injury (SCI) elicits robust neuroinflammation that eventually exacerbates the initial damage to the spinal cord. L-arginine is critical for the responsiveness of T cells, which are important contributors to neuroinflammation a
Externí odkaz:
https://doaj.org/article/131c8bf7f47d4b248625a981c6655811
Autor:
Lambertsen, Minna Christiansen Lund, Ditte Gry Ellman, Pernille Vinther Nielsen, Stefano Raffaele, Marta Fumagalli, Raphael Guzman, Matilda Degn, Roberta Brambilla, Morten Meyer, Bettina Hjelm Clausen, Kate Lykke
Publikováno v:
Biology; Volume 12; Issue 6; Pages: 845
Clinical and animal model studies have implicated inflammation and glial and peripheral immune cell responses in the pathophysiology of spinal cord injury (SCI). A key player in the inflammatory response after SCI is the pleiotropic cytokine tumor ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::589d328d73a675f86379642eeb8eed9b
Autor:
Si Yun Ng, Alan Yiu Wah Lee
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Traumatic brain injury (TBI) remains one of the leading causes of morbidity and mortality amongst civilians and military personnel globally. Despite advances in our knowledge of the complex pathophysiology of TBI, the underlying mechanisms are yet to
Externí odkaz:
https://doaj.org/article/0855dd20f70741d3bde192a8209ae36a